|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy显示文摘Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in patients.Independent of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,known as diabetic cardiomyopathy(DCM).Four decades of research in experimental animal models and advances in clinical imaging techniques suggest that DCM is a progressive disease,beginning early after the onset of type 1 and type 2 diabetes,ahead of left ventricular remodeling and overt diastolic dysfunction.Although the molecular pathogenesis of early DCM still remains largely unclear,activation of protein kinase C appears to be central in driving the oxidative stress dependent and independent pathways in the development of contractile dysfunction.Multiple subcellular alterations to the cardiomyocyte are now being highlighted as critical events in the early changes to the rate of force development,relaxation and stability under pathophysiological stresses.These changes include perturbed calcium handling,suppressed activity of aerobic energy producing enzymes,altered transcriptional and posttranslational modification of membrane and sarcomeric cytoskeletal proteins,reduced actin-myosin cross-bridge cycling and dynamics,and changed myofilament calcium sensitivity.In this review,we will present and discuss novel aspects of the molecular pathogenesis of early DCM,with a special focus on the sarcomeric contractile apparatus. | Mark T Waddingham Amanda J Edgley Hirotsugu Tsuchimochi Darren J Kelly Mikiyasu Shirai James T Pearson | 2015 | World Journal of Diabetes2015，6，7： | 10 |
| 2 | Apllication of maximum likelihood principal component analysis incomplete data sets and calibration transfer显示文摘 | Darren T Andrews Peter D Wentzell | 1997 | Analytica Chimica Acta1997，，350： | 2 |
| 3 | Acetyl salicylic acid (aspirin) and salieylie acid induce multiple stress toleraee in bean and tomato plants显示文摘 | Tissa S Darren T Eric B | 2000 | Plant Growth Regul2000，30，： | 1 |
| 4 | Fostering resilience to extreme events within infrastructure systems:characterizing decision contexts for mitigation and adaptution显示文摘 | McDaniels T Stephanie Chang Darren Cole | 2008 | Global Environmental Change2008，18，： | 1 |
| 5 | Ligand Design and Self-Recognition: A Copper (II) Complex that Dimerizes Via Hydrogen Bonds显示文摘 | Darren J B Jason R T | 2002 | Inorganica Chimica Acta2002，341，： | 1 |
| 6 | The interrelationship of sputum inflammatory markers in patients with chronic bronchitis显示文摘 | Adan T Hill Darren Bayley Robert A | 1999 | Am J Respir Crit Care Med1999，160，： | 1 |
| 7 | Enhanced external counterpulsation for ischemic heart disease:a look behind the curtain 显示文摘 | Randy W Darren P Darren T | 2012 | Exerc Sport Sci Rev2012，40，3： | 1 |
| 8 | Interleukin-10 Gene Expression in Acute Virus-induced Asthma显示文摘 | Grissell T V Powell H Darren R | 2005 | Am J Respir Crit Care Med2005，172，： | 1 |
| 9 | Virtual reality Pow- erwall versus conventional microscope for viewing patholo- gy slides : an experimental comparison 显示文摘 | Darren T Naomi J O John H | 2009 | Histopatholo- gy2009，55，3： | 1 |
| 10 | Tracking with vir- tual slides: a tool to study diagnostic error in histopathol- ogy显示文摘 | Darren T Chee H L Derek M | 2009 | Histopathology2009，55，1： | 1 |
| 11 | Virtual slides: an introduction 显示文摘 | Darren T | 2009 | Diagnostic Histopathology2009，15，2： | 1 |
| 12 | Ureteroscopy and holmium:YAG laser lithotripsy: an emerging definitive management strategy for symptomatic ureteral calculi in pregnancy显示文摘 | James D Watterson Andrew R Girvan Darren T Beiko Linda Nott Timothy A Wollin Hassan Razvi John D Denstedt | 2002 | Urology2002，，： | 1 |
| 13 | Removal of inorganic constituents of biomass Feedstocks by mechanical dewatering and leaching 显示文摘 | SCOTT Q T CHARLES M K DARREN M | 1997 | Biomass and Bioenergy1997，12，4： | 1 |
| 14 | Synthesis and anti- bacterial activity of C-6 carbamate ketolides, a novel series of orally active ketolide antibiotics 显示文摘 | Henninger T C Xu Xiao-dong Darren A | 2004 | Bioorganie & Medidinal Chemistry Letters2004，14，： | 1 |
| 15 | The fate inorganic constituents of biomass in fluidized bed gasification显示文摘 | Scott Q T Charles M K Darren M I | 1998 | Fuel1998，77，3： | 1 |
| 16 | Removal of inorganic constituents of biomass feedstocks by mechanical dewatering and leaching显示文摘 | SCOTT Q T CHARLES M K DARREN M I | 1997 | Biomass and Bioenergy1997，12，4： | 1 |
| 17 | Targeted disruption of the murine CCK-1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function显示文摘 | Darren T Kent L | 2006 | Am J Physiol Gastrointest Liver Physiol2006，290，： | 1 |
| 18 | Liquid chromatog- raphy-tandem mass spec- trometry method for the simultaneous quantitative determination of the organ ophodphorus pesticides dimethoate, fenthion, diazinon and chlorphyrifos in human blood 显示文摘 | Paul S Paul J T Darren R | 2009 | Journal of Chromat- ography B2009，，877： | 1 |
| 19 | Removal of inorganic constituents of biomass feedstocks by mechanical dewatering and leaching 显示文摘 | Scott Q T Charles M K Darren M I | 1997 | Biomass and Bioenergy1997，12，4： | 1 |
| 20 | The lipocalin protein family:Structural and sequence overview 显示文摘 | Darren R Flower Anthony C T North Clare E Sansom | 2000 | Biochimica et Biophysiea Acta2000，1482，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员