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| 1 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 2 | 冠状动脉钙化用于指导个性化阿司匹林治疗以预防心血管病:基于多民族动脉粥样硬化研究显示文摘最近美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)的一级预防指南建议,低剂量阿司匹林治疗仅适用于年龄40~70岁、患动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVD)风险较高,但出血风险不高的成年人。然而,尚不清楚如何更准确地识别出这些患者。根据2019年降低心血管病相对危险度和出血风险的阿司匹林荟萃分析研究数据,本研究旨在评估冠状动脉钙化(coronary artery calcium,CAC)在指导阿司匹林在一级预防中如何使用的价值。 | 周卫(译) 叶鹏(摘/审校) Achirica MC Miedema MD McEvoy JW Rifai MA Greenland P Dardari Z Budoff M Blumenthal RS Yeboah J Duprez DA Mortensen MB Dzaye O Hong J Nasir K Blaha MJ | 2020 | 中华高血压杂志2020，28，4： | 2 |
| 3 | Profile of microbial communities present in tibico(sugary kefir)grains from different Brazilian States显示文摘 | da CP MIGUEL M G CARDOSO P G MAGALHES K T | 2011 | World Journal of Microbiology and Biotechnology2011，27，8： | 1 |
| 4 | Pennicillin in duced epileptiform activity in the hippocampal in vitro preparation显示文摘 | Prince DA Crews J K | 1981 | Ann Neurol1981，1，： | 1 |
| 5 | Water in car- bon dioxide macroemulsions and miniemulsions with a hydrocar- bon surfactant显示文摘 | Johnston K P Cho Dongman Da Rocha S R P | 2001 | Langmuir2001，17，23： | 1 |
| 6 | Utilization of freshwater and ocean water by coastal plants of southern Florida显示文摘 | Sternberg L da S L Swart P K | 1987 | Ecology1987，68，： | 1 |
| 7 | Correlation of CT findings with clinical evalua- tions in 261 patients with symptomatic bronehieetasis显示文摘 | Lynch DA Newell J Hale V Dver D Corkerv K Fox NL Ger-end P Fick R | 1999 | AJR Am J Roentyenol1999，173，1： | 1 |
| 8 | Characterization of a two - aqueous phase system con- taining a nonionic surfactant 显示文摘 | TEIXEIRA DA SILVA DE LA SALLES K CANSELIER J P GOURDON C | 2005 | Journal of Dispersion Science and Technolagy2005，26，3： | 1 |
| 9 | A review of complications associated with vertebroplasty and kyphoplasty as reported to the food and drug administration medical device related web site显示文摘 | Gailoud P Murphy K | 2004 | Vase Interv Radiol2004，15，11： | 1 |
| 10 | Quadrature sampling schemes with improved image rejection显示文摘 | PUN K P da FRANCA J E CARLOS A L | 2003 | IEEE Trans Circ and Syst2003，50，9： | 1 |
| 11 | Investigation of false pos- itive results with an oral fluid rapid HIV-1/2 antibody test显示文摘 | Jafa K Patel P Mackellar DA etal | 2007 | PLoS One2007，2，1： | 1 |
| 12 | Comparison of multi-lineage cells from human adipose tissue and bone marrow显示文摘 | De Ugarte DA Morizono K Elbarbary A Alfonso Z Zuk PA Zhu M Dragoo JL Ashjian P Thomas B Benhaim P Chen I Fraser J Hedrick MH | | 0，，： | 1 |
| 13 | A review of compli- ca-tions associated with vertebroplasty and kyphoplasty as re-ported to the food and drug administration medical devicere- lated web site显示文摘 | Nussbaum DA Gailloud P Murphy K | 2004 | J Vas lnterv Radiol2004，15，11： | 1 |
| 14 | Infection of CD127+ (interleukin-7 receptor + ) CD4+ ceils and overexpression of CTLA-4 are linked to loss of antigen- specific CD4 T cells during primary human immunodeficiency virus type 1 infection 显示文摘 | Zaunders JJ Ip S Munier ML Kaufmann DE Suzuki K Brereton C Sasson SC Seddiki N Koelsch K Landay A Grey P Finlayson R Kaldor J Rosenberg ES Walker BD Fazekas de St Groth B Cooper DA Kelleher AD | 2006 | J Virol2006，80，10： | 1 |
| 15 | A database of simple sequence repeats from cereal and legume expressed sequence tags mined in silico, survey and evaluation 显示文摘 | Jayashree B Punna R Prasacl P Bantte K Hash T Chandra S Hoisington DA Varshney RK | 2006 | In Silico Biol2006，6，6： | 1 |
| 16 | Anti- mtillerian hormone protein expression is reduced during the initial stages of follicle development in human polycystic ovaries显示文摘 | Stubbs SA Hardy K Da Silva-Buttkus P | 2005 | J Clin Endoerinol Metab2005，90，10： | 1 |
| 17 | nficroRNA-21 promotes Ilal7 differentiation and mediates experimental autoimmune encephalomyelitis显示文摘 | Murugaiyan G da Cunha A P Ajay A K | 2015 | J Clin Invest2015，125，3： | 1 |
| 18 | Cost layered double hydroxides for CO2 capture:Structure evolution and regeneration显示文摘 | RAM REDDY M K XU Z P LU G Q DINIZ da COSTA J C | 2006 | Ind Eng Chem Res2006，45，22： | 1 |
| 19 | Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy显示文摘 | Monks DA Rao P Mo K | 2008 | Horm Behav2008，53，5： | 1 |
| 20 | Surfactant-modified CO2-water interface: A molecular view显示文摘 | Da Rocha S R P Johnstom K P Rossky P J | 2002 | J Phys Chem B2002，106，13： | 1 |
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