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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Review on modelling of corrosion under droplet electrolyte for predicting atmospheric corrosion rate显示文摘Atmospheric corrosion of metals is the most common type of corrosion which has a significant impact on the environment and operational safety in various situations of everyday life.Some of the common examples can be observed in land,water and air transportation systems,electronic circuit boards,urban and offshore infrastructures.The dew drops formed on metal surface due to condensation of atmospheric moisture facilitates corrosion as an electrolyte.The corrosion mechanisms under these droplets are different from classically known bulk electrolyte corrosion.Due to thin and non-uniform geometric thickness of the droplet electrolyte,the atmospheric oxygen requires a shorter diffusion path to reach the metal surface.The corrosion under a droplet is driven by the depletion of oxygen in the center of the droplet compared to the edge,known as differential aeration.In case of a larger droplet,differential aeration leads to preferential cathodic activity at the edge and is controlled by the droplet geometry.Whereas,for a smaller droplet,the oxygen concentration remains uniform and hence cathodic activity is not controlled by droplet geometry.The geometry of condensed droplets varies dynamically with changing environmental parameters,influencing corrosion mechanisms as the droplets evolve in size.In this review,various modelling approaches used to simulate the corrosion under droplet electrolytes are presented.In the efforts of developing a comprehensive model to estimate corrosion rates,it has been noted from this review that the influence of geometric evolution of the droplet due to condensation/evaporation processes on corrosion mechanisms are yet to be modelled.Dynamically varying external factors like environmental temperature,relative humidity,presence of hygroscopic salts and pollutants influence the evolution of droplet electrolyte,making it a complex phenomenon to investigate.Therefore,an overview of available dropwise condensation and evaporation models which describes the formation and the evolution of droplet geometry are also presented from an atmo s pheric corrosion viewpoint. | Bangalore Gangadharacharya Koushik Nils Van den Steen Mesfin Haile Mamme Yves Van Ingelgem Herman Terryn | 2021 | Journal of Materials Science & Technology2021，，3： | 3 |
| 3 | Embankment Widening with the Gap-method 显示文摘 | A N G Van Meurs A Van Den Berg et | 1999 | Rotterdam:Geotechnical Engineering for Transportation Infrastructure1999，，： | 2 |
| 4 | Reevaluation of formulas for predicting creatinine clearance in adults and children,using compensated creatinine methods显示文摘 | Wuyts B Bernard D Van den Noortgate N | 2003 | Clin Chem2003，49，61： | 1 |
| 5 | Molecular and biological characterization of human monoclonal antibodies bingding to the spike and nucleocapsid proteins of Severe Acute Respiratory Syndrome Coronavirus显示文摘 | Van den Brink E N Meulen J Cox F | 2005 | J Virol2005，79，： | 1 |
| 6 | Recovery of selenium from copper anode slimes 显示文摘 | DUTTON W A van den STEEN A J THEMELIS N J | 1971 | Metallurgical Transactions1971，2，： | 1 |
| 7 | Cochlear implantation in children 显示文摘 | Van den Broek P Cohen N O' Donoghue | 1995 | Int J Pediatr Otorhinolaryngol1995，，： | 1 |
| 8 | Epigenetic mechanisms in migraine:a promising avenue?显示文摘 | Eising E Datson N A van den Maagdenberg A M | 2013 | BMC Med2013，11，1： | 1 |
| 9 | Land Tenure Security and Land Investments in Northwest China 显示文摘 | MA X HEERINK N VAN IERLAND E M VAN DEN BERG Sill X | 2013 | China Agricultural Economic Review2013，5，2： | 1 |
| 10 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis 显示文摘 | Denning DW Ribaud P Milipied N | 2002 | Clin Infect Dis2002，34，5： | 1 |
| 11 | Cytomegalovirus cell tropism,replication,and gene transfer in brain显示文摘 | van den Pol A N Mocarski E Saederup N | 1999 | J Neurosci1999，19，10： | 1 |
| 12 | Video monitoring of neovessel occlusion induced by photodynamic therapy with verteporfm in the CAM model 显示文摘 | I)ebefve E Pegaz B van den Bergh H Wagnieres G Lange N Ballini JP | 2008 | Angiogenesis2008，11，3： | 1 |
| 13 | Efficacy and safety of Voriconazole in the treatment of acute invasive aspergillosis显示文摘 | Denning DW Ribaud P Milpied N | | 0，，： | 1 |
| 14 | Cerebral white matter lesions and the risk of dementia显示文摘 | Prins N D van Dijk E J den Heijer T | | 0，，10： | 1 |
| 15 | Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults 显示文摘 | Larsen N Vogensen FK van den Berg FW | 2010 | PLoS One2010，5，2： | 1 |
| 16 | Work En gagement and Machiavellianism in the Ethical Lead ership Process 显示文摘 | DEN HARTOC D N BELSCHAK F D | 2012 | Journal of Business Ethics2012，107，1： | 1 |
| 17 | Subclinicalhypothyroidism and the risk of coronary heart disease andmorta!ity显示文摘 | Rodondi N den Elzen WP Bauer DC | 2010 | JAMA2010，304，12： | 1 |
| 18 | Thin-layer response and spectral bandwidth显示文摘 | De Voogd N den Rooijen N | 1983 | Geophysics1983，48，1： | 1 |
| 19 | Up- dating situation models during reading of news reports:evi- dence from empirical data and simulations显示文摘 | Blanc N Kendeou P van den Broek P Brouillet D | 2008 | Discourse Processes2008，，2： | 1 |
| 20 | Primary lymphoma of the cervix uteri:a diagnostic challenge:Report of two cases and review of the literature显示文摘 | Van Renterghem N De Paepe P Van den Broeeke R | 2005 | Eur J Gynaecol Oncol2005，26，1： | 1 |
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