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| 1 | 选择性CD_(34)^+细胞和非选择性自体外周血干细胞移植治疗多发性骨髓瘤的比较研究显示文摘目的 明确选择性CD3 4+ 细胞自体外周血干细胞移植 (APBSCT)治疗多发性骨髓瘤 (MM)的临床效果。方法 对 2 1例接受CD3 4+ 细胞APBSCT治疗的MM患者 (选择组 )和另外 2 1例接受非选择性APBSCT的MM患者 (对照组 )的造血恢复时间、有效率、生存率、移植相关不良反应、移植费用进行比较。两组病例在年龄、初诊时血清 β2 微球蛋白水平和移植时疾病状态均具有可比性 ,诱导治疗及预处理方案基本相同。结果 与对照组相比 ,选择组患者回输的CD3 4+ 细胞数显著偏低 [对照组和选择组分别为 9.4(1.1~ 15 .0 )× 10 6/kg和 2 .2 (0 .5~ 14.3)× 10 6/kg](P <0 .0 0 1) ,中性粒细胞恢复至≥ 0 .5× 10 9/L和血小板恢复至≥ 2 0× 10 9/L的中位时间 ,在选择组分别为 10d和 9d ,对照组分别为 9.5d(P=0 .35 7)和 4.5d(P =0 .0 0 5 )。两组的治疗有效率相似 (选择组 85 .7% ,对照组 90 .4% ) ,3年无病生存率 (选择组和对照组分别为 32 %和 39% )和总生存率 (选择组和对照组分别为 85 %和 79% )两组相比差异无显著性 ,而且使用非选择性APBSCT可明显降低移植费用。结论 选择性CD3 4+ 细胞APBSCT与非选择性APBSCT相比 ,并不能改善MM的临床治疗结果 ,而且移植费用更大。 | 唐晓文 N Morineau N Milpied P Moreau R Bataille JL Harousseau | 2001 | 中华血液学杂志2001，22，7： | 5 |
| 2 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 3 | Neuropilin-1 is not a marker of human Foxp3 + Treg显示文摘 | Milpied P Renand A Bruneau J | 2009 | Eur J Immunol2009，39，6： | 1 |
| 4 | Longitudinal study of bacterial,viral,and fungal infections in adult recipients of bone marrow transplants显示文摘 | Ninin E Milpied N Moreau P | 2001 | Clin Infect Dis2001，33，： | 1 |
| 5 | Efficacy and safety of Voriconazole in the treatment of acute invasive aspergillosis显示文摘 | Denning DW Ribaud P Milpied N | | 0，，： | 1 |
| 6 | Initial treatment of aggressive lymphoma with high-dose chemotherapy and autolo- gous stem-cell support显示文摘 | Milpied N Deconinck E Gaillard F | 2004 | N Engl J Med2004，350，13： | 1 |
| 7 | First-line rituximab (R) high-dose therapy (R-HDT) versus R-CHOP14 for young adults with diffuse large B-cell lymphoma: Preliminary results of the GOELAMS 075 prospective multicenter randomized trial显示文摘 | Le Gouill S Milpied NJ Lamy T | 2011 | Journal of Clinical Oncology2011，15，29： | 1 |
| 8 | Correction:Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Correction to:Cellular&Molecular Immunology https://doi.org/10.1038/S41423-020-00574-8,published online 25 November 2020 In the version of this article initially published,two unintended errors were made during manuscript preparation.(1)The figure legend for Panel 3B was missing;the correct legend is as follows. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 9 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis显示文摘 | Ribaud P Milpied N | 2002 | Clin Infect Dis2002，34，： | 1 |
| 10 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis显示文摘 | Denning DW Ribaud P Milpied N | 2002 | Clin Infect Dis2002，34，： | 1 |
| 11 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis 显示文摘 | Denning DW Ribaud P Milpied N | 2002 | Clin Infect Dis2002，34，5： | 1 |
| 12 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis 显示文摘 | Denning D W Ribaud P Milpied N | 2002 | Clin Infect Dis2002，34，1： | 1 |
| 13 | Impact of fuel properties on the performances and knock behaviour of a downsized turbocharged DI SI engine-focus on octane numbers and latent heat of vaporization显示文摘 | Milpied J Jeuland N Marchal A | | 0，，01： | 1 |
| 14 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis 显示文摘 | Denning DW Ribaud P Milpied N | 2002 | Clin Infect Dis2002，34，5： | 1 |
| 15 | Primary cutaneous eryptococcosis in HIV-negative subjects 显示文摘 | Quereux G Milpied B Morin O | 2001 | Ann Dermatol Venereol2001，128，101： | 1 |
| 16 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis显示文摘 | DENNING DW RIBAUD P MILPIED N | 2002 | Clin Infect Dis2002，35，10： | 1 |
| 17 | Initial treatment of aggressive lymphoma with high-dose chemotherapy and autologous stem-cell support显示文摘 | Milpied N Deconinck E Gaillard F | 2004 | N Engl J Med2004，350，： | 1 |
| 18 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis显示文摘 | RIBAUD P MILPIED N | 2002 | Clin Infect Dis2002，34，： | 1 |
| 19 | Initial treatment of aggressive lymphoma with high-dose chemotherapy and autologous stem-cell support显示文摘 | Milpied N Deconinck E Gaillard F | 2004 | N Engl J Med2004，350，： | 1 |
| 20 | Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis显示文摘 | DENNING D RIBAUD P MILPIED N | 2002 | Clin Infect Dis2002，34，5： | 1 |
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