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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam显示文摘Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0±9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI<23kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85 ± 4.97 pmol/L vs 15.60 ± 8.70 pmol/L, P<0.001 ) and higher insulin resistance index in (2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration,insulin resistance index between male and female was observed (P>0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P<0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12 × [skin fold thickness at A8 point (mm)] - 1.Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12 × [skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. | Toan C Nguyen Khoa TA Pham Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen | 2005 | Journal of Geriatric Cardiology2005，2，4： | 4 |
| 3 | A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export 显示文摘 | Havarstein L S Diep D B Nes I F | 1995 | Mol Microbiol1995，16，2： | 1 |
| 4 | Antagonistic activity of Lactobacillus plantarum Cll :two new two-peptide bacteriocins,plantaricins E F and J K,and the induction factor plantaricin A显示文摘 | Anderssen E L Diep D B Nes I F | 1998 | Appl Environ Microbiol1998，64，： | 1 |
| 5 | PPARa activator effects on Ang II-induced vascular oxidative stress and inflammation显示文摘 | Diep QN Amiri F Touyz RM Cohn JS Endemann D Neves MF | 2002 | Hypertension2002，40，： | 1 |
| 6 | Biosynthesis of Bacteriocins in Lactic Acid Bacteria显示文摘 | NES I F DIEP D B HAVARSTEIN L S | 1996 | Antonie Van Leeuwenhoek1996，70，24： | 1 |
| 7 | Non equilibrium molecular motion in a hypersonic shock wave显示文摘 | PHAM-Van DIEP G ERWIN D MUNTZ E P | | 0，，4918： | 1 |
| 8 | Bacteriocin diversity in Streptococcus and Enterococcus显示文摘 | NES I F DIEP D B HOLO H | 2007 | Journal of Bacteriology2007，189，4： | 1 |
| 9 | Biosynthesis in lactic acid bacteria显示文摘 | Nes I F Diep D B Havarstein L S | 1996 | Antonie van Leeuwenhoek1996，70，： | 1 |
| 10 | Antagonistic activity of Lactobacillus plantarum C11:two new two-peptide bacteriocins,plantaricins EF and JK,and the induction factor plantaricin A显示文摘 | Anderssen E L Diep D B Nes I F | | 0，，06： | 1 |
| 11 | A bacteriocin-like peptide induces bacteriocin synthesis in Lactobacillus plantarum C11显示文摘 | Diep D B Havarstein L S Nes I F | | 0，，04： | 1 |
| 12 | Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11显示文摘 | Diep D B Havarstein L S Nes I F | | 0，，15： | 1 |
| 13 | Adjustment of antibiotic treatment according to the results of blood cultures leads to decreased antibiotic use and costs显示文摘 | Berild D Mohseni A Diep LM | 2006 | J Antimicrob Chemother2006，57，： | 1 |
| 14 | Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain 显示文摘 | DIEP D B HOEN N BACKMAN M | 2004 | Brain Res Dev BrainRes2004，153，2： | 1 |
| 15 | Biosynthesis of Bacteriocins in Lactic Acid Bacteria 显示文摘 | NES I F DIEP D B HAVARSTEIN L S | 1996 | Antonie van Leeuwenhoek1996，70，： | 1 |
| 16 | An overview of the mosaic bac- teriocin pin loci from Lactobacillus plantarum 显示文摘 | Diep DB Sytaume D Kjos M | 2009 | Peptides2009，30，8： | 1 |
| 17 | Evidence for dual functionality of the operon plnABCD in the regulation of bacteriocin production in LactobaciUus plantarum显示文摘 | DIEP D JOHNSBORG O ARNE P | 2001 | Molecular Microbiology2001，41，3： | 1 |
| 18 | An overview of the mosaic bacteriocin pin loci from Lactobacillus plantarum显示文摘 | DIEP D B STRAUME D KJOS M | 2009 | Peptides2009，30，8： | 1 |
| 19 | Common mechanisms of target cell recognition and immunity for class Ⅱ bacteriocins显示文摘 | Diep D B SkaugenM Salehian Z | 2007 | Proc Natl Acad Sci USA2007，104，7： | 1 |
| 20 | Use of Lactobacilli and their pheromone-based regulatory mechanism in gene expression and drug delivery显示文摘 | DIEP D B MATHIESEN G EIJSINK V G H | 2009 | Current Pharmaceuti- cal Biotechnology2009，10，1： | 1 |
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