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您的检索式：作者名="DING Deling"
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| 1 | The grafts modified by heparinization and catalytic nitric oxide generation used for vascular implantation in rats显示文摘Small-diameter(<6mm)vascular grafts are increasingly needed in peripheral vascular surgery but have few successes because of acute thrombosis,incomplete endothelialization and intimal hyperplasia after implantation.This study used electrospun poly(ε-caprolactone)as the matrix material.Heparin and selenium-containing catalyst-organoselenium modified polyethyleneimine were introduced through layer-by-layer assembly in order to build a vascular graft with in situ nitric oxide(NO)generation.The aim of this study was to explore the application of the graft with improved histocompatibility and biological function for vascular implantation in rats.After implantation in rats,compared to poly(ε-caprolactone),the modified grafts could promote the adhesion and proliferation of endothelial cells,and inhibit the adhesion of smooth muscle cells.The modified grafts remarkably promoted endothelialization,inhibited intimal hyperplasia and increased the ratio of alternatively activated macrophages(M2)to classical activated macrophages(M1).This work constructed a vascular graft with heparinization and catalytic NO generation for improving the vascularization,and accelerating the tissue regeneration by regulating the inflammatory response.The present study indicates that it is a promising method for regulating response and tissue regeneration of small diameter vascular grafts by a novel approach of combining heparinization and catalytic NO generation. | Jingchen Gao Li Jiang Qinge Liang Jie Shi Ding Hou Di Tang Siyuan Chen Deling Kong hufangWang | 2018 | Regenerative Biomaterials2018，5，2： | 4 |
| 2 | Self-immolative micellar drug delivery:The linker matters显示文摘Redox-responsive polymer-drug conjugate micelles are excellent nanoscale vehicles for self-immolative intracellular drug delivery.To covalently connect the polymer and drug,disulfide-bearing linkers,such as 3,3'-dithiodipropionic acid (DDPA) and 4,4'-dithiodibutyric add (DDBA),are used.In this paper,we report the influence of linker length on the therapeutic outcome of redox-sensitive conjugate micelles.Curcumin was selected as the model drug and it was conjugated to a multivalent methoxy poly(ethylene glycol)-polylysine copolymer with DDPA or DDBA as the linker.The obtained two polymer-curcumin conjugates were amphiphilic and could self-assemble into micelles that have a hydrodynamic diameter less than 100 nm.The loading of curcumin in both micelles was above 20% (w/w).Irrespective of the linker type,micelle disassembly was observed due to the collapse of the disulfide bond in a reducing environment.However,the rate of curcumin release was much faster with the DDBA linker than with the DDPA linker as the side product was a 5-membered ring with a low ring strain.The linker length-induced variation of curcumin release kinetics caused a significant difference in the intracellular drug concentration and a higher cytotoxicity was witnessed in three model cell lines (HeLa,PC3,and 4T1) for the micelles with a DDBA linker compared to those containing a DDPA linker.As expected,this phenomenon was also observed in HeLa tumor-bearing nude mice in vivo.The current work highlights the significance of linker length in engineering redox-responsive on-demand delivery systems. | Xuan Meng Min Gao Jian Deng Di Lu Aiping Fan Dan Ding Deling Kong Zheng Wang Yanjun Zhao | 2018 | Nano Research2018，11，12： | 2 |
| 3 | Preparation and characterization of uniform circinate aggregates of sheet ZnO nanoparticles显示文摘Uniform circinate aggregates of sheet ZnO nanoparticles with a specific surface area of 24 m2·g-1 were prepared by the direct precipitation method.The circinate aggregates were hexagonal ZnO,with the wall thickness ranging from 0.5 to 1 μm and the diameter ranging from 5 to 10 μm.The backs of the circinate aggregates were regularly arranged by numerous sheet ZnO nanoparticles with a thickness of 30-80 nm and a diameter of 300-400 nm.The precursors were aggregates of sheet Zn5(CO3)2(OH)6 nanoparticles,which were decomposed into ZnO by calcining in air in the range of 200-285°C,and the ZnO retained the similar special structure.The C2H5OH content had a significant effect on the formation of sheet ZnO.The centripetal force,the Van der Waals force,and the hydrogen bond were deduced as the driving forces of the formation of circinate. | LIU Jiaxiang DING Deling WANG Lisheng and HAN Yuexin | 2008 | Rare Metals2008，27，1： | 1 |
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