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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 3 | Research and experiments of the dynamical model system for short-term climate prediction显示文摘 | Ding Y H Liu Y .M Song J | | 气候与环境研究0，，： | 2 |
| 4 | Evolution of endovascular mechanical thrombectomy for acute ischemic stroke显示文摘Acute ischemic stroke(AIS) is a common medical problem associated with significant morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility criteria for intravenous thrombolysis(IVT) with recombinant tissue plasminogen activator, and its efficacy for large vessel occlusion is poor. Therefore, an increasing number of patients with AIS are being treated with endovascular mechanical thrombectomy when IVT is ineffective or contraindicated. Rapid advancement in catheter-based and endovascular device technology has led to significant improvements in rates of cerebral reperfusion with these devices. Stentrievers and modern aspiration catheters have now surpassed earlier generation devices in the degree and rapidity of revascularization. This progress has been achieved with no concurrent increase in risk of major complications or mortality, both when used alone or in combination with IVT. The initial randomized controlled trials comparing endovascular therapy to IVT for AIS failed to show superior outcomes with endovascular treatment, butkey limitations of each trial may limit the significance of these results to current practice. While endovascular devices and operator experience continue to evolve, we are optimistic that this will be accompanied by improvements in patient outcomes. This review highlights the major endovascular devices used in current practice and the trials which have investigated their efficacy. | Colin J Przybylowski Dale Ding Robert M Starke Christopher R Durst R Webster Crowley Kenneth C Liu | 2014 | World Journal of Clinical Cases2014，2，11： | 2 |
| 5 | Application of bis (iminophosphorane) in heterocyclic synthesis:new entries to symmetrically or unsymmetrically substituted thieno dipyrimidine -4,5 ( 3H, 6H ) -diones 显示文摘 | Ding M W Xu S Z Zhao J F | 2004 | J Org Chem2004，69，24： | 1 |
| 6 | Discovery of a potent inhibitor of the antiapoptotic protein Bcl-x(L) from NMR and parallel synthesis显示文摘 | Petros A M Dinges J Augeri D J | 2006 | J MedChem2006，49，： | 1 |
| 7 | Wind-blown origin of the Pliocene red clay formation in the central Loess Plateau 显示文摘 | Ding Z L Sun J M Liu T S Zhu R X Yang S L Guo B | 1998 | Earth and Planetary Science Letters1998，161，： | 1 |
| 8 | A facile and selective synthesis of 2-alkylamino-4H-imidazolin-4-ones显示文摘 | Ding M W Xu Z F Liu Z J | 2001 | Synth Commun2001，31，： | 1 |
| 9 | XPS studies on the electronic structure of bonding between solid and solutes:Adsorption of arsenate,chromate,phosphate,Pb2+,and Zn2+ ions on amorphous black ferric oxyhydroxide显示文摘 | DING M JONG B H W S DE ROOSENDAAL S J | 2000 | Geochimica et Cosmochimica Acta2000，64，6： | 1 |
| 10 | Evidence of aerobic denitrification显示文摘 | Ding A Z Fu J M Sheng G Y | 2000 | Chin Scie Bull2000，45，3： | 1 |
| 11 | DNMT3A mutations in acute myeloid leukemia显示文摘 | Ley T J Ding L Walter M J | 2010 | New England Journal of Medicine2010，363，25： | 1 |
| 12 | Microstructure and mechanical properties of Mg-Zn-Si-based alloys显示文摘 | Yuan G Y Liu M P Ding W J | | 0，，1： | 1 |
| 13 | Fuzzy multi- state system: General definition, and performance assessment显示文摘 | Ding Y Zuo M J Lisnianski A | 2008 | IEEE Trans on Reliability2008，57，4： | 1 |
| 14 | Extreme Learn- ing Machine for Regression and Multiclass Classification 显示文摘 | Huang G B Zhnu H M Ding X J | 2012 | IEEE Trans on Systems Matt and Cybernetics- part B: Cybernetics2012，42，2： | 1 |
| 15 | Expression pattern genomic struc- ture, and promoter analysis of the gene encoding stilbene synthase from Chinese wild Vitis pseudoreticulata显示文摘 | XU W R YU Y H ZHOU Q DING J H DAI L M XIE X Q XU Y ZHANG C H WANG Y J | 2011 | Journal of Experimen- tal Botany2011，62，8： | 1 |
| 16 | Synthesis and degradation of non- toxic biodegradable waterborne polyurethanes elastomer with poly(e- caprolactone) and poly(ethylene glycol) as soft segment显示文摘 | JIANG X LI J H DING M M | 2007 | European Polymer Journal2007，43，： | 1 |
| 17 | Demethylation of microRNA -142 induced by demethylation agents plays a suppressive role in osteosarcoma cells 显示文摘 | Ding M Hu J Ni L | 2015 | Oncol Lett2015，9，5： | 1 |
| 18 | Flammable, thermal, and mechanical properties of intumescent flame retardant PP/LDH nanocomposites with different divalent cations显示文摘 | ZHANG M DING P QU B J | 2009 | Polymer Composites2009，30，10： | 1 |
| 19 | Morphology and water vapor permeability of temperature-sensitive polyu- rethanes显示文摘 | Ding X M Hu J L Tao X M | 2008 | Journal of Applied Polymer Science2008，107，： | 1 |
| 20 | Reveled refinement study of the pressuredependence of the internal structural parameter u in the wurtzite phase of ZnO显示文摘 | Liu H Ding Y Somayazulu M Leian J Shu J Husermann D Mao H K | 2005 | Phys Rev B2005，71，21： | 1 |
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