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1459篇 您的检索式：作者名="DJ L"

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	题名	作者	年代	出处	被引量
1	Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO).	CY Luo L Wang C Sun DJ Li	2011	Cellular & Molecular Immunology2011，8，1：	33
2	The European stroke scale显示文摘	Hantson L DJ Weardt W De Keyser J	1994	Stroke1994，25，：	2
3	Phakic anterior chamber intraocular lenses显示文摘	Werner L Apple DJ Izak AM	2001	Int Ophthalmol Clin2001，41，：	2
4	Monoclonal antibodies targeting the VEGF receptor-2 (F1k1/KDR) as an anti-angiogenic therapeutic strategy 显示文摘	Hicklin DJ Zhu Z	1998	Cancer Metastasis Rev1998，17，2：	1
5	Effects of transforming growth factor betal released from biodegradable polymer microparticles on marrow stromal osteoblasts cultured on poly(prophylen fumarate)substrtes显示文摘	Lu L Kim DJ	2000	J Biomed Mater Res2000，50，3：	1
6	显示文摘	Cheng Y L Dai J M Wu DJ	2010	J Magn Magn Mater2010，322，：	1
7	Identification of a second murine interleukin-11 receptor-chain gene (IL11Ra2)with a restricted pattern of expression显示文摘	Robb L Hilton DJ Brook-Carter PT	1997	Genomics1997，，：	1
8	Hospice attitudes among assisted living and nursing home administrators,and the long-term care hospice attitudes scale显示文摘	Dobbs DJ Hanson L Zimmerman S	2006	J Palliat Med2006，9，6：	1
9	Secretory IgA N- andO-glycans provide a link between the innate and adaptive im-mune systems显示文摘	Royle L Roos A Harvey DJ	2003	J Biol Chem2003，278，20：	1
10	The Canadian Critical Trials Group显示文摘	Heyland DK Cook DJ Griffith L et aL The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient	1999	American Journal of Respiratory and Critical Care Medicine1999，159，41：	1
11	Monoclonal antibodies targe-ting the VEGF receptor-2 (Flkl/KDR) as an anti-angiogenic therapeuticstrategy显示文摘	Witte L Hicklin DJ Zhu Z	1998	Cancer Metastasis Rev1998，17，：	1
12	Development of multiplex PCR system with 15 X-STR loci and genetic analysis in three nationality popu- lations from China显示文摘	Liu QL Lu DJ Quan L	2012	Electropharesis2012，33，8：	1
13	Adoptive immu- notherapy for cancer: building on success 显示文摘	Gattinoni L Powell DJ Jr Rosenberg SA	2006	Nat Rev hnnmnol2006，6，5：	1
14	Immunonutrition and surgical practice显示文摘	Bouchier Hayes DJ	1999	Proc Nutr Soc1999，58，：	1
15	Impaired retinal function and vitamin A availability in mice lacking retinal binding protein显示文摘	Blaner WS Salcow DJ	1999	EMBO J1999，18，17：	1
16	Construction of a whole-cell gene reporter for the fluorescent bioassay of nitrate显示文摘	Taylor C J Bain L A Richardson DJ	2004	Anal Biochem2004，328，1：	1
17	Cardiovascular failure in mouse embryos deficient in VEGF receptor 3显示文摘	Dumont DJ Jussila L Taipale J	1998	Science1998，282，5390：	1
18	Rifampicin-induced acute renal failure:a series of 60 patients显示文摘	Covic A Goldsmith DJ Segall L	1998	Nephral Dial Transplant1998，13，：	1
19	Diabetic neuropathic foot ulcers and amputation显示文摘	Margolis DJ Allen-Taylor L Hoffstad O	2005	Wound Repair Regen2005，13，：	1
20	Adoptive im munotherapy for cancer: building on suceess显示文摘	Gattiononi L Powell DJ Tr Rosenberg SA	2006	Nat Rev Immu- nol2006，6，5：	1

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