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| 1 | Estrogen enhances the functions of CD4^(+)CD25^(+)Foxp3^(+) regulatory T cells that suppress osteoclast differentiation and bone resorption in vitro显示文摘Cross-talk has been shown to occur between the immune system and bone metabolism pathways.In the present study,we investigated the impact of CD4^(+)CD25^(+)Foxp3^(+) regulatory T(Treg)cells on osteoclastogenesis and bone resorption.Treg cells that were isolated and purified from peripheral blood mononuclear cells(PBMCs)of healthy adults inhibited both the differentiation of osteoclasts(OCs)from human embryo bone marrow cells(BMCs)and the pit formation in a dose-dependent manner.In cell cocultures,the production levels of both interleukin-10(IL-10)and transforming growth factor-beta 1(TGF-β1)were proportionally upregulated as the ratio of Treg cells to BMCs was increased,and the inhibition of OC differentiation and bone resorption by Treg cells was completely reversed by anti-IL-10 and anti-TGF-β1 antibodies.Treatment of BMC and Treg cell cocultures with 17β-estradiol(E2)at concentrations between 10^(-7) and 10^(-9) mol/l suppressed OC differentiation and bone resorption more efficiently than it did in cultures of BMCs alone;this enhanced suppression occurred via the stimulation of Treg cell IL-10 and TGF-b1 expression.These data suggest that Treg cells suppress OC differentiation and bone resorption by secreting IL-10 and TGF-β1.E2 enhances the suppressive effects of Treg cells on OC differentiation and bone resorption by stimulating IL-10 and TGF-β1 secretion from these cells.Therefore,Treg cell-derived IL-10 and TGF-b1 are likely involved in the regulation of E2 on bone metabolism and represent potential therapeutic targets for the treatment of postmenopausal osteoporosis(PMO). | CY Luo L Wang C Sun DJ Li | 2011 | Cellular & Molecular Immunology2011，8，1： | 33 |
| 2 | Synthesis and Structure of A Novel Caged Bicyclic Phosphate Flame Retardant显示文摘A novel caged bicyclic phosphate flame retardant tri(1-oxo-2,6,7-trioxa-l-phosphabicyclo [2.2.2] octane-methyl) phosphate (Trimer) was synthesized from 1-oxo-4-hydroxymethyl-2,6,7-trioxa-l-phosphabicyclo [2.2.2] octane (PEPA) and phosphorus oxychloride in this paper. Its structure was characterized by elemental analysis, FTIR, 1H NMR, 31P NMR and X-ray diffraction analysis. | Li, X Ou, YX Zhang, YH Lian, DJ | 2000 | Chinese Chemical Letters2000，11，10： | 28 |
| 3 | Schistosomiasis in the Peo- ple's Republic of China: the era of the Three Gorges Dam显示文摘 | McManus DP Gray DJ Li Y | 2010 | Clin Microbiol Rev2010，23，2： | 1 |
| 4 | In Vivo Correlation between Blood T2^* and Oxygen Saturation显示文摘 | Li D Waight DJ Wang Y | 1998 | J Magn Reson Imaging1998，8，6： | 1 |
| 5 | Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis显示文摘 | Li JS Sexton DJ Mick N etal | 2000 | Clin Infect Dis2000，30，4： | 1 |
| 6 | Effect of cell-based VEGF gene therapy ola healing of a segmental bone defect显示文摘 | Li R Stewart DJ von Schroeder HP | 2009 | J Orthop Res2009，27，1： | 1 |
| 7 | Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis显示文摘 | Li JS Sexton DJ Mick N | 2000 | Clin Infect Dis2000，30，4： | 1 |
| 8 | Genomic sequence a- nalysis of Epstein - Barr virus strain GD1 from a naso- pharyngeal carcinoma patient 显示文摘 | Zeng MS Li DJ Liu QL | 2005 | JVirol2005，79，15： | 1 |
| 9 | The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophage显示文摘 | Feng B Yao PM Li YK Zhang DJ Harding HP Rong JX | 2003 | Nat Cell Biol2003，5，9： | 1 |
| 10 | PTEN tumor suppressor regu- lates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms显示文摘 | Freeman DJ Li AG Wei G | 2003 | Cancer cell2003，3，2： | 1 |
| 11 | Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5′untranslated region in translational control显示文摘 | Bevitt DJ Li Z Lindrop JL | 2005 | Gene2005，10，8： | 1 |
| 12 | PTEN tumor suppressor regulates p53 protein levers and activity through phosphatase-dependent and independent mechanisms显示文摘 | Freeman DJ Li AG Wei G | 2003 | Cancer Cell2003，3，2： | 1 |
| 13 | Transport,manipulation and reaction of biological cells on-chip using electrokinetic effects显示文摘 | Li PCH Harrison DJ | | 0，，： | 1 |
| 14 | m paired endothelial regulation of ventricular relaxation in cardiac hypertrophy: role of reactive oxygen species and NADPH oxidase显示文摘 | MacCarthy PA Grieve DJ Li JM | 2001 | Circulation2001，104，： | 1 |
| 15 | Varicocele as a progressive lesion:positive effect of varicocele repair 显示文摘 | Cozzolino DJ Lipshultz LI | 2001 | Hum Reprod Update2001，7，1： | 1 |
| 16 | Thermometric analysis of intra - cavitary hyperthermia for esophageal cancer 显示文摘 | Qi C Li DJ | 1999 | Int Hyperthermia1999，15，5： | 1 |
| 17 | Doxorubiein physical state in solution and inside liposomes loaded via a pH gradient 显示文摘 | LI X HIRSH DJ CABRAL-LILLY A | 1998 | Biochim Biophys Acta1998，1415，： | 1 |
| 18 | Controlled treadmill exerciseeliminates chondroid deposits and restores tensile properties in anew murine tendinopathy model显示文摘 | BELL R LI J?GORSKI DJ? | 2013 | J Biomech2013，46，3： | 1 |
| 19 | Arsenic (+3 oxidation state)methyltransferase and the methylation of arsenicals显示文摘 | Thomas DJ Li J Waters SB | | 0，，： | 1 |
| 20 | The cytotoxic principles of pseudolarix kaempfefi: pseudolaric acid- A and -B and related derivatives 显示文摘 | Pan DJ Li ZL Hu CQ | 1990 | Planta Med1990，56，： | 1 |
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