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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Why interleukin-10 supplementation does not work in Crohn's disease patients显示文摘Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are chronic intestina disorders, which are on the increase in 'Westernised' countries. IBD can be caused by both genetic and environmental factors. Interleukin-10 (IL-10) is an immunoregulatory cytokine that has been identified as being involved in several diseases including IBD. Studies have shown that polymorphisms in the promoter region reduce serum levels of IL-10 and this reduction has been associated with some forms of IBD. Mouse models have shown promising results with IL-10 supplementation, as such IL-10 supplementation has been touted as being a possible alternative treatment for CD in humans. Clinical trials have shown that recombinant human IL-10 is safe and well tolerated up to a dose o 8 μg/kg. However, to date, the results of the clinica trials have been disappointing. Although CD activity was reduced as measured by the CD activity index IL-10 supplementation did not result in significantly reduced remission rates or clinical improvements when compared to placebo. This review discusses why IL-10supplementation is not effective in CD patients currently and what can be addressed to potentially make IL-10 supplementation a more viable treatment option in the future. Based on the current research we conclude that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL-10 supplementation could be of benefit. | Gareth J Marlow Dominique van Gent Lynnette R Ferguson | 2013 | World Journal of Gastroenterology2013，19，25： | 9 |
| 3 | Is There a Possibility of a Cure in Patients With Colorectal Peritoneal Carcinomatosis Amenable to Complete Cytoreductive Surgery and Intraperitoneal Chemotherapy?显示文摘 | Diane Goéré David Malka Dimitri Tzanis Vinicius Gava Valérie Boige Clarisse Eveno Léon Maggiori Frédéric Dumont Michel Ducreux Dominique Elias | 2013 | Annals of Surgery2013，，6： | 2 |
| 4 | Experimental study of pulse-jet cleaning of bag filters supported by rigid rings显示文摘 | Xavier Simon Sandrine Chazelet Dominique Thomas Denis Bémer Roland Régnier | 2006 | Powder Technology2006，，2： | 2 |
| 5 | Hepatic Resection for Noncolorectal Nonendocrine Liver Metastases: Analysis of 1452 Patients and Development of a Prognostic Model显示文摘 | René Adam Laurence Chiche Thomas Aloia Dominique Elias Rémy Salmon Michel Rivoire Daniel Jaeck Jean Saric Yves Patrice Le Treut Jacques Belghiti Georges Mantion Gilles Mentha | 2006 | Annals of Surgery2006，，4： | 2 |
| 6 | Definition of Patients Presenting a High Risk of Developing Peritoneal Carcinomatosis After Curative Surgery for Colorectal Cancer: A Systematic Review显示文摘 | Charles Honoré Diane Goéré Amine Souadka Frédéric Dumont Dominique Elias | 2013 | Annals of Surgical Oncology2013，，1： | 2 |
| 7 | Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans,a major facilitator transporter involved in azole resistance显示文摘 | Benedicte R Zuzana K Dominique S | 2006 | Microbiology2006，152，： | 1 |
| 8 | Enteric coated HPMC capsules designed to achieve intestinal targeting显示文摘 | Ewart T Cole Robert A Scott Alyson L Connor Ian R Wilding Hans-U Petereit Carsten Schminke Thomas Beckert Dominique Cadé | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 9 | Peripheral pulmonary arteries : optimization of spiral CT acquision protocol Thoracic显示文摘 | Martine R Jacques R Dominique A | 1997 | Radiology1997，204，： | 1 |
| 10 | Measurement of procalcitonin levels in children with Bacterial or viral meningitis显示文摘 | Dominique G Josette R | 1997 | Clinical Infectious Diseases1997，24，： | 1 |
| 11 | Effects of freezing and thawing on mammalian oocyte 显示文摘 | Jondet M Dominique S Scholler R | 1984 | Cryobiology1984，21，2： | 1 |
| 12 | New cerebrosides from Euryale ferox 显示文摘 | Zhao H R Zhao S X Dominique Guiuaume | 1991 | J Nat Prod1991，571，： | 1 |
| 13 | Experimental Study of Sound Propagation through Bubbly Water:Com- parison with Optical Measurements显示文摘 | Vincent D Dominique R R Dominique D | 2011 | IEEE Journal of Oceanic Engineering2011，36，1： | 1 |
| 14 | A MYB Transcription Factor Regulates Very-Long-Chain Fatty Acid Biosynthesis for Activation of the Hypersensitive Cell Death Response in Arabidopsis(W)(OA)显示文摘 | Raffaele Sylvain Vailleau Fabienne Léger Amandine Joubès Jér?me Miersch Otto Huard Carine Blée Elisabeth Mongrand Sébastien Domergue Frédéric Roby Dominique | 2008 | Plant Cell2008，，3： | 1 |
| 15 | Steroid saponins from fenugreek seeds:extraction,purification,and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R P Yves D S Dominique M H | 1995 | Steroids1995，60，10： | 1 |
| 16 | Steroid saponins from fenugreek seeds:extraction,purification and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R Yves D Dominique M | 1995 | Steroids1995，60，： | 1 |
| 17 | Epidemiology of in- fection in critically ill patients with acute renal failure显示文摘 | Emmelie R Dominique M Vandijck PhD | 2009 | Crit Care Med2009，37，： | 1 |
| 18 | Influence of environmental temperature on growth performance in pigs显示文摘 | Dominique R | 1991 | INRA Prod Anim1991，4，1： | 1 |
| 19 | peripheral pulmonary arteries; Optimization of the spiral CT acquisition protocol Thoracic显示文摘 | Martine R Jacques R dominique A | 1997 | Radiology1997，204，： | 1 |
| 20 | Family history of malignant and benign thyroid diseases and risk of thyroid cancer: a population-based case–control study in New Caledonia显示文摘 | Christophe Leux Thérèse Truong Claire Petit Dominique Baron-Dubourdieu Pascal Guénel | 2012 | Cancer Causes & Control2012，，5： | 1 |
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