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| 1 | Review of risk factors for human echinococcosis prevalence on the Qinghai-Tibet Plateau, China: a prospective for control options显示文摘Objective: Echinococcosis is a major parasitic zoonosis of public health importance in western China. In 2004, the Chinese Ministry of Health estimated that 380,000 people had the disease in the region. The Qinghai-Tibet Plateau is highly co-endemic with both alveolar echinococcosis (AE) and cystic echinococcosis (CE). In the past years, the Chinese government has been increasing the financial support to control the diseases in this region. Therefore, it is very important to identify the significant risk factors of the diseases by reviewing studies done in the region in the past decade to help policymakers design appropriate control strategies. Review: Selection criteria for which literature to review were firstly defined. Medline, CNKI (China National Knowledge Infrastructure), and Google Scholar were systematically searched for literature published between January 2000 and July 2011. Significant risk factors found by single factor and/or multiple factors analysis were listed, counted, and summarized. Literature was examined to check the comparability of the data;age and sex specific prevalence with same data structures were merged and used for further analysis. A variety of assumed social, economical, behavioral, and ecological risk factors were studied on the Plateau. Those most at risk were Tibetan herdsmen, the old and female in particular. By analyzing merged comparable data, it was found that females had a significant higher prevalence, and a positive linearity relationship existed between echinococcosis prevalence and increasing age. In terms of behavioral risk factors, playing with dogs was mostly correlated with CE and/or AE prevalence. In terms of hygiene, employing ground water as the drinking water source was significantly correlated with CE and AE prevalence. For definitive hosts, dog related factors were most frequently identified with prevalence of CE or/and AE;fox was a potential risk factor for AE prevalence only. Overgrazing and deforestation were significant for AE prevalence only. Conclusion: Tibetan herdsmen communities were at the highest risk of echinococcosis prevalence and should be the focus of echinococcosis control. Deworming both owned and stray dogs should be a major measure for controlling echinococcosis;treatment of wild definitive hosts should also be considered for AE endemic areas. Health education activities should be in concert with the local people's education backgrounds and languages in order to be able to improve behaviors. Further researches are needed to clarify the importance of wild hosts for AE/CE prevalence, the extent and range of the impacts of ecologic changes (overgrazing and deforestation) on the AE prevalence, and risk factors in Tibet. | Qian Wang Yan Huang Liang Huang Wenjie Yu Wei He Bo Zhong Wei Li Xiangman Zeng Dominique A Vuitton Patrick Giraudoux Philip S Craig Weiping Wu | 2014 | Infectious Diseases of Poverty2014，3，1： | 35 |
| 2 | Impact of overgrazing on the transmission of Echinococcus multilocularis in Tibetan pastoral communities of Sichuan Province,China显示文摘背景过度放牧被假定增加是包虫 multilocularis 的中间的主人的小哺乳动物的人口密度,在 Qinghai 西藏高原的牙槽的包虫病的病原体。这研究测试了过度放牧可能支持的假设通过增加小哺乳动物的人口的包虫 multilocularis 传播,在擦伤惯例的西藏的牧剧 communities.Methods 的中间的主人,小哺乳动物索引和狗包虫 rnultilocularis 感染数据被收集分析在用的 nonpararnetric 测试和多重逐步的逻辑 regression.Results 过度放牧和包虫 rnultilocularis 传播之间的关系调查一公社的牧场存在,可得到的牧草为放牧是缺乏的。开(普通) 牧场被过度放牧并且与附近的 fenced 相比有小哺乳动物的更高的洞穴密度(私人) 牧场;由附近的 fenced 区域测量的开的牧场上的这个高过度放牧压力在开的牧场导致了小哺乳动物的更高的洞穴密度。在开的牧场的小哺乳动物的中部的洞穴密度独立地与附近犬的包虫 multilocularis 感染被联系(P=0.003, OR=1.048 ) 过度放牧的 .Conclusion 可以通过增加小哺乳动物的人口密度支持包虫 multilocularis 的传播。 | WANG Qian XIAO Yong-fu Dominique A Vuitton Peter M Schantz Francis Raoul Christine Budke Maiza Campos-Ponce Philip S Craig Patrick Giraudoux | 2007 | Chinese Medical Journal2007，，3： | 20 |
| 3 | Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode显示文摘AIM: To explore the effect of Echinococcus multilocularis (E. multilocularis) on the activation of mitogen-activated protein kinase (MAPK) signaling pathways and on liver cell proliferation. METHODS: Changes in the phosphorylation of MAPKs and proliferating cell nuclear antigen (PCNA) expression were measured in the liver of patients with alveolar echinococcosis (AE). MAPKs, MEK1/2 [MAPK/ extracellular signal-regulated protein kinase (ERK) kinase] and ribosomal S6 kinase (RSK) phosphorylation were detected in primary cultures of rat hepatocytes in contact in vitro with (1) E. multilocularis vesicle fluid (EmF), (2) E. multilocularis-conditioned medium (EmCM). RESULTS: In the liver of AE patients, ERK 1/2 and p38 MAPK were activated and PCNA expression was increased, especially in the vicinity of the metacestode. Upon exposure to EmF, p38, c-Jun N-terminal kinase (JNK) and ERK1/2 were also activated in hepatocytes in vitro, as well as MEK1/2 and RSK, in the absence of any toxic effect. Upon exposure to EmCM, only JNK was up-regulated. CONCLUSION: Previous studies have demonstrated an influence of the host on the MAPK cascade in E. multilocularis. Our data suggest that the reverse, i.e. parasite-derived signals efficiently acting on MAPK signaling pathways in host liver cells, is actually operating. | Ren-Yong Lin Jun-Hua Wang Xiao-Mei Lu Xiao-Tao Zhou Georges Mantion Hao Wen Dominique A Vuitton Lysiane Richert | 2009 | World Journal of Gastroenterology2009，15，17： | 15 |
| 4 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 5 | Auto-versus allo-transplantation of the liver for end-stage alveolar echinococcosis?显示文摘'We dreamt of it; they did it!' Reading the paper by WEN et al in this issue of the Chinese Medical Journal,1 we can not help but remember when our colleague Prof.Jean-Philippe Miguet, a hepatologist who was the first at the beginning of the 1970s to review the clinical cases of alveolar echinococcosis (AE)observed in our region of Eastern France and to renew our interest in that disease, used to tell Prof.Michel Gillet,his colleague hepatic surgeon who was the first in 1986 to succeed in transplanting a liver in a patient with AE:2 'You should rather resect the parasitic lesions from the diseased liver of the patient after removing it from the patient's body and re-transplant it!' We were at the beginning of the 1980s; it sounded like a joke, and for the first time, 30 years later, it has become true.In addition to a technical performance, this success in doing ex vivo resection of AE lesions and auto-transplanting the remaining liver is likely to become a demonstration of the best indication of that technique. | Georges A Mantion | 2011 | Chinese Medical Journal2011，，18： | 3 |
| 6 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 7 | Enteric coated HPMC capsules designed to achieve intestinal targeting显示文摘 | Ewart T Cole Robert A Scott Alyson L Connor Ian R Wilding Hans-U Petereit Carsten Schminke Thomas Beckert Dominique Cadé | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 8 | Peripheral pulmonary arteries : optimization of spiral CT acquision protocol Thoracic显示文摘 | Martine R Jacques R Dominique A | 1997 | Radiology1997，204，： | 1 |
| 9 | Mobilization and domain of bone marrow stromal cells in myocardial infarction显示文摘 | Bindu B Dominique S Abdulaziz A | 2003 | Eur J Cardio Surg2003，24，： | 1 |
| 10 | Ritnximab therapy for re- fractory interstitial lung disease related to antisynthetase syndrome 显示文摘 | Marie l Dominique S Janvresse A | 2012 | Respir Meal2012，106，4： | 1 |
| 11 | Immortalization of a primate hipotent epithelial liver stem cell显示文摘 | Jean- Etienne A Ibrahim D Dominique MC | 2002 | PNAS2002，99，6： | 1 |
| 12 | Acrylamlde: Update on selected research activities conducted by the European food and drink industry显示文摘 | Dominique T Anders A Peter A | 2005 | Journal of AOAC International2005，88，1： | 1 |
| 13 | A functional genetic variation of the 5-HT2a receptor affects human memory显示文摘 | Dominique JF Katharina H Amanda A | 2003 | Nature2003，6，11： | 1 |
| 14 | Expression of three members of the ACC synthase gene family in deep water rice by submergence, wounding and hormonal treatments 显示文摘 | Dominique V D S Somboon A Wim V C | 1997 | Plant Science1997，124，： | 1 |
| 15 | peripheral pulmonary arteries; Optimization of the spiral CT acquisition protocol Thoracic显示文摘 | Martine R Jacques R dominique A | 1997 | Radiology1997，204，： | 1 |
| 16 | Structural characterization of a mechanically milled carbon nanotube/aluminum mixture 显示文摘 | Dominique Poirier Raynald Gauvin Robin A L Drew | 2009 | Compos Part A: Appl Sci Manuf2009，40，9： | 1 |
| 17 | BiocatalystEngineering by Assembly of Fatty Acid Transport and Oxida-tion Activities for In Vivo Application of Cytochrome P -450bm_3 Monooxygenase 显示文摘 | Silke S Marcle G Wubbolts Dominique A | 1998 | Applied And EnvironmentalMicrobiology1998，64，10： | 1 |
| 18 | Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial显示文摘 | Talmadge E King Carlo Albera Williamson Z Bradford Ulrich Costabel Phil Hormel Lisa Lancaster Paul W Noble Steven A Sahn Javier Szwarcberg Michiel Thomeer Dominique Valeyre Roland M du Bois | 2009 | The Lancet . 2009 (9685)2009，，： | 1 |
| 19 | Synthesis of nanosized zirconium carbide route显示文摘 | Mickael Bogicevic et by a sol-gel Society 2007 Doll e Dominique Gosset Christine al | 2007 | Journal of the European Ceramic2007，27，： | 1 |
| 20 | Comparative effects of dietary methylmercury on gene expression in liver,skeletal muscle,and brain of the zebrafish(Danio rerio)显示文摘 | Gonzalez P Dominique Y Massabuau JC Boudou A Bourdineaud JP | 2005 | Environ Sci Technol2005，39，11： | 1 |
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