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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews显示文摘 | Paul K Nelson Bradley M Mathers Benjamin Cowie Holly Hagan Don Des Jarlais Danielle Horyniak Louisa Degenhardt | 2011 | The Lancet . 2011 (9791)2011，，： | 2 |
| 3 | Management practices of hepatitis C virus infected alcoholic hepatitis patients:A survey of physicians显示文摘AIM:To survey gastroenterologists and hepatologists regarding their current views on treating hepatitis C virus(HCV) infected alcoholic hepatitis(AH) patients.METHODS:A sixteen item questionnaire was electronically mailed to gastroenterologists and hepatologists.A reminder was sent after 2 mo to increase the response rate.Participation of respondents was confidential.Accessing secured web site to respond to the questionnaire was considered as informed consent.Responses received on the secured website were downloaded in an excel sheet for data analysis.RESULTS:Analyzing 416 responses to 1556(27% response rate) emails,57% respondents(56% gastroenterologists) reported HCV prevalence > 20% amongst AH patients.Sixty nine percent often treated AH and 46% preferred corticosteroids(CS).Proportion of respondents with consensus(75% or more respondents agreeing on question) on specific management of HCV infected AH were:routine HCV testing(94%),HCV not changing response to CS(80%) or pentoxifylline(91%),no change in approach to treating HCV infected AH(75%).None of respondent variables:age,specialty,annual number of patients seen,and HCV prevalence could predict respondent to be in consensus on any of or all 4 questions.Further,only 4% would choose CS for treating HCV infected AH as opposed to 47% while treating HCV negative AH.CONCLUSION:Gastroenterologists and hepatologists believe that AH patients be routinely checked for HCV.However,there is lack of consensus on choice of drug for treatment and outcome of HCV positive AH patients.Studies are needed to develop guidelines for management of HCV infected AH patients. | Ashwani K Singal Habeeb Salameh Anjna Singal Sarat C Jampana Daniel H Freeman Karl E Anderson Don Brunder | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 2 |
| 4 | Computer aided design fluid power systems显示文摘 | MAX D DON R | 1982 | Proceeding of the National Conference on Power Transnission Volume 1x 9th Annual Meeting1982，9，1： | 1 |
| 5 | Hard carbon nanocomposite films with low stress显示文摘 | TAY B K CHENG Y H DON X Z | 2001 | Dia-mond Relat Mater2001，10，： | 1 |
| 6 | Extinguishment of cooking oil fires by water mist fire suppression systems 显示文摘 | Liu Zhigang Andrew K Kim Don Carpenter | 2004 | Fire Technology2004，40，： | 1 |
| 7 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 8 | Preparation and properties of nano-silica modified nega- tive acrylate photoresist 显示文摘 | Lee C K Don T M Lai W C Chert C C Lin D J Cheng L P | 2008 | Thin Solid Films2008，516，23： | 1 |
| 9 | Meshless methods for shear-deformable beams and plates 显示文摘 | Donning B M Liu W K | 1998 | Computer Methods in Applied Mechanics and Engineering1998，152，1： | 1 |
| 10 | Characterization of acrylic copolymers applied in negative-type photoresist via a ternary composition diagram 显示文摘 | Lee C K Don T M Lin D J Chen C C Cheng L P | 2008 | Journal of Applied Polymer Science2008，109，1： | 1 |
| 11 | Extinguishment of Cooking Oil Fires by Water Mist Fire Suppression Systems 显示文摘 | Liu Zhigang Andrew K Kim Carpenter Don | 2004 | Fire Technology2004，40，： | 1 |
| 12 | Age specific differences in pediatric obstructive sleep apnea显示文摘 | Don D M Geller K A Koempel J A | 2009 | Int J Pediatr Otorhinolaryn Gol2009，73，7： | 1 |
| 13 | Histone deacetylase 6 plays a roleas a distinct regulator of diverse celluar processes 显示文摘 | Li YX Don^iee S So Hee K | 2012 | FEBS Journal2012，280，3： | 1 |
| 14 | Meshless methods for shear deformable beams and plates 显示文摘 | Donning B M Liu W K | 1998 | Computer Methods in Applied Mechanics and Engineering1998，152，： | 1 |
| 15 | Thin-glomeru- lar-basement-membrane uephropathy: is it a benign cause of isolated hematuria? 显示文摘 | Gandhi S Kalantar-Zadeh K Don BR | 2002 | South Med J2002，95，7： | 1 |
| 16 | Children' s lnternet searching on complex problems : Performance and process analysis 显示文摘 | Schaehter J Chung G K Don' A | 1998 | Journal of the American Society for Information Science1998，49，9： | 1 |
| 17 | Pediatric total tonsillectomy using co - blation compared to conventional electro- surgery: a prospective, controlled, singleblind study显示文摘 | Stoker K E Don D M Kealg D R | 2004 | Otolaryngol Head Neck Surg2004，130，： | 1 |
| 18 | Photovoltaic and rectification properties of A1/Mg phthalocyanine/Ag Schottky-barrier cells 显示文摘 | GHOSH A K DON L TOM F | 1974 | J of Appl Phys1974，45，1： | 1 |
| 19 | Responsibility and opportunity:Moving the library to the forefront显示文摘 | Bosseau Don L Martin Susan K | 1997 | Journal of Academic Librarianship1997，23，4： | 1 |
| 20 | The effect of endurance training on serum triiodothyronine kinetics in man:physieal conditioning marked by enhaneed thyroid hormone metabolism显示文摘 | Rone J K Dons R F Reed H L | 1992 | Clin Endoerinol ( Oxf)1992，37，4： | 1 |
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