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| 1 | Role of inflammation and infection in the pathogenesis of human acute liver failure: clinical implications for monitoring and therapy显示文摘Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multiorgan failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research. | Mhairi C Donnelly Peter C Hayes Kenneth J Simpson | 2016 | World Journal of Gastroenterology2016，22，26： | 13 |
| 2 | Viral hepatitis in 2021:The challenges remaining and how we should tackle them显示文摘Viral hepatitis results in 1.4 million deaths annually.The World Health Organization(WHO)set an ambitious target to eliminate viral hepatitis by 2030,but significant challenges remain.These include inequalities in access to healthcare,reaching at risk populations and providing access to screening and effective treatment.Stigma around viral hepatitis persists and must be addressed.The WHO goal of global elimination by 2030 is a worthy aim,but remains ambitious and the coronavirus 2019 pandemic undoubtedly has set back progress.This review article will focus on hepatitis A to E,highlighting problems that have been resolved in the field over the past decade,those that remain to be resolved and suggest directions for future problem solving and research. | Rebecca Dunn Aaron Wetten Stuart McPherson Mhairi C Donnelly | 2022 | World Journal of Gastroenterology2022，28，1： | 4 |
| 3 | Gastrointestinal and liver disease in patients with schizophrenia:A narrative review显示文摘Schizophrenia is a severe mental illness which can have a devastating impact onan individual’s quality of life. Comorbidities are high amongst patients and lifeexpectancy is approximately 15 years less than the general population. Despite thewell-known increased mortality, little is known about the impact of gastrointestinaland liver disease on patients with schizophrenia. We aimed to reviewthe literature and to make recommendations regarding future care. Literaturesearches were performed on PubMed to identify studies related to gastrointestinaland liver disease in patients with schizophrenia. High rates of chronic liverdisease were reported, with Non-Alcoholic Fatty Liver Disease being of particularconcern;antipsychotics and metabolic syndrome were contributing factors. Ratesof acute liver failure were low but have been associated with antipsychotic useand paracetamol overdose. Coeliac disease has historically been linked to schizophrenia;however, recent research suggests that a causal link is yet to be proven.Evidence is emerging regarding the relationships between schizophrenia andpeptic ulcer disease, inflammatory bowel disease and irritable bowel syndrome;clinical vigilance regarding these conditions should be high. Patients with schizophreniapoorly engage with bowel cancer screening programmes, leading to latediagnosis and increased mortality. Clozapine induced constipation is a significantissue for many patients and requires close monitoring. There is a significantburden of gastrointestinal and liver disease amongst patients with schizophrenia.Better levels of support from all members of the medical team are essential toensure that appropriate, timely care is provided. | Rebecca K Grant William M Brindle Mhairi C Donnelly Pauline M McConville Thomas G Stroud Lorenzo Bandieri John N Plevris | 2022 | World Journal of Gastroenterology2022，28，38： | 2 |
| 4 | Celiac disease:Management of persistent symptoms in patients on a gluten-free diet显示文摘AIM:To investigate all patients referred to our center with non-responsive celiac disease (NRCD),to establish a cause for their continued symptoms.METHODS:We assessed all patients referred to our center with non-responsive celiac disease over an 18-mo period.These individuals were investigated to establish the eitiology of their continued symptoms.The patients were first seen in clinic where a thorough history and examination were performed with routine blood work including tissue transglutaminase antibody measurement.They were also referred to a specialist gastroenterology dietician to try to identift any lapses in the diet and sources of hidden gluten ingestion.A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible.Colonoscopy,lactulose hydrogen breath testing,pancreolauryl testing and computed tomography scan of the abdomen were undertaken if the symptoms persisted.Their clinical progress was followed over a minimum of 2 years.RESULTS:One hundred and twelve consecutive patients were referred with NRCD.Twelve were found not to have celiac disease (CD).Of the remaining 100 patients,45% were not adequately adhering to a strict gluten-free diet,with 24 (53%) found to be inadvertently ingesting gluten,and 21 (47%) admitting noncompliance.Microscopic colitis was diagnosed in 12% and small bowel bacterial overgrowth in 9%.Refractory CD was diagnosed in 9%.Three of these were diagnosed with intestinal lymphoma.After 2 years,78 patients remained well,eight had continuing symptoms,and four had died.CONCLUSION:In individuals with NRCD,a remediable cause can be found in 90%:with continued gluten ingestion as the leading cause.We propose an algorithm for investigation. | David H Dewar Suzanne C Donnelly Simon D McLaughlin Matthew W Johnson H Julia Ellis Paul J Ciclitira | 2012 | World Journal of Gastroenterology2012，18，12： | 2 |
| 5 | Product distributions of the Fischer-Tropsch synthesis on precipitated iron catalysts显示文摘 | DONNELLY T J SATTERFIELD C N | 1989 | Appl Catal1989，52，1： | 1 |
| 6 | Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong显示文摘 | Donnelly C A Ghani A C Leung G M | 2003 | Lancet2003，361，： | 1 |
| 7 | Variation in TCF7L2 influences therapeutic response to sulfonylureas显示文摘 | Pearson ER Donnelly LA Kimber C | 2007 | Diabetes2007，56，： | 1 |
| 8 | Detection of knockdown resis- tance (kdr) mutations in Anopheles gambiae: a comparison of two new high - throughput assays with existing methods 显示文摘 | C Bass D Nikou MJ Donnelly | 2007 | Malar J2007，6，： | 1 |
| 9 | Pandemic of a strain of influenza A ( HIN1 ) : Early Findinga 显示文摘 | Fraser C Donnelly CA Cauhemez S | 2009 | Science2009，324，5934： | 1 |
| 10 | Ontogeny of the neutral amino acid transporter SNAT 1 in the developing rat 显示文摘 | Weiss MD Donnelly WH Rossignol C | 2005 | J Mol Histol2005，36，4： | 1 |
| 11 | Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma显示文摘 | Hothersall EJ Chaudhuri R McSharry C Donnelly I Lafferty J McMahon AD | | 0，，： | 1 |
| 12 | Pandemic potential of a strain of influenza A(H1N1):early findings显示文摘 | Fraser C Donnelly CA Cauchemez S | | 0，，5934： | 1 |
| 13 | The evo- lution and state of modern technology for prostate cryosurgery 显示文摘 | SALIKEN J C DONNELLY B J REWCASTLE J C | 2002 | Urology2002，60，2： | 1 |
| 14 | Pandemic potential of a strain of influenza A (H1N1):early findings显示文摘 | FRASER C DONNELLY C A CANEHEMEZ S | 2009 | Science2009，324，5934： | 1 |
| 15 | The aetin eytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of eyelosporine A显示文摘 | FAUL C DONNELLY M MERSCHER-GOMEZ S | 2008 | Nat Med2008，14，9： | 1 |
| 16 | Conjugated linoleic acid (CLA) inhibits expression of the Spot 14(THRSP) and fatty acid synthase genes and impairs the growth of human breast cancer and liposarcoma cells显示文摘 | DONNELLY C OLSEN A M LEWIS L D | 2008 | Nutrition Cancer2008，61，1： | 1 |
| 17 | Pandemic potential of a strain of influenza A (H1N1): Early findings显示文摘 | Fraser C Donnelly CA Cauchemez S | 2009 | Science2009，324，5934： | 1 |
| 18 | The microbial diversity of laboratory-scale wetlands appears to be randomly assembled显示文摘 | Baptism J C Davenport R J Donnelly T | 2008 | Water research2008，42，12： | 1 |
| 19 | Dielectric and electromechanical properties of Pb( Mgl/3, Nb2/3 )03 - PbTiO3 thin films grown by pulsed laser deposition显示文摘 | DONNELLY N J CATALAN G MORROS C | 2003 | J Appl Phys2003，93，： | 1 |
| 20 | Pandemic poten- itial of a strain of influenza A ( HI N1 ) : Early findings 显示文摘 | FRASER C DONNELLY CA CAUCHEMEZ S | 2009 | Science2009，324，5934： | 1 |
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