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| 1 | Preparation and Properties of Cellulose Nanomaterials显示文摘Cellulose is the most abundant biomass material in nature and it is mainly extracted from natural or lignocellulosic fibers.After purification,cellulose fibers exhibit two interesting features for their further transformation into nanomaterials:a hierarchical and multi-level strcture,and a semicrystalline microstructure.Different forms of cellulose nanomaterials,resulting from a top-down deconstructing strategy(cellulose nanocrystals(CNCs),cellulose nanofibrils(CNFs))or bottom-up strategy(bacterial cellulose(BC))can be prepared.Multiple mechanical shearing actions applied to cellulosic fibers release more or less the nanofibrils individually.A controlled strong acid hydrolysis treatment can be applied to cellulosic fibers allowing dissolution of non-crystalline domains.Such cellulose nanomaterials have been the focus of an exponentially increasing number of works or reviews devoted to understand such materials and their applications.They have a high potential for an emerging industry.In the nanoscale,cellulose exhibits specific properties broadening the applications of this naturally occurring polymer.An overview of existing methods for the preparation of cellulose nanomaterials and their specific properties that outperform and contrast with cellulose in the microscale is proposed. | Alain Dufresne | 2020 | Paper And Biomaterials2020，5，3： | 19 |
| 2 | Redox proteomics of tomato in response to Pseudomonas syringae infection显示文摘Unlike mammals with adaptive immunity,plants rely on their innate immunity based on pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)for pathogen defense.Reactive oxygen species,known to play crucial roles in PTI and ETI,can perturb cellular redox homeostasis and lead to changes of redox-sensitive proteins through modification of cysteine sulfhydryl groups.Although redox regulation of protein functions has emerged as an important mechanism in several biological processes,little is known about redox proteins and how they function in PTI and ETI.In this study,cysTMT proteomics technology was used to identify similarities and differences of protein redox modifications in tomato resistant(PtoR)and susceptible(prf3)genotypes in response to Pseudomonas syringae pv tomato(Pst)infection.In addition,the results of the redox changes were compared and corrected with the protein level changes.A total of 90 potential redox-regulated proteins were identified with functions in carbohydrate and energy metabolism,biosynthesis of cysteine,sucrose and brassinosteroid,cell wall biogenesis,polysaccharide/starch biosynthesis,cuticle development,lipid metabolism,proteolysis,tricarboxylic acid cycle,protein targeting to vacuole,and oxidation–reduction.This inventory of previously unknown protein redox switches in tomato pathogen defense lays a foundation for future research toward understanding the biological significance of protein redox modifications in plant defense responses. | Kelly Mayrink Balmant Jennifer Parker Mi-Jeong Yoo Ning Zhu Craig Dufresne Sixue Chen | 2015 | Horticulture Research2015，2，1： | 7 |
| 3 | Short natural-fibre reinforced polyethylene and natural rubber composites: Effect of silane coupling agents and fibres loading显示文摘 | M. Abdelmouleh S. Boufi M.N. Belgacem A. Dufresne | 2006 | Composites Science and Technology2006，，7： | 4 |
| 4 | MicroRNAs as emerging biomarkers and therapeutic targets for pancreatic cancer显示文摘Despite tremendous efforts from scientists and clinicians worldwide, pancreatic adenocarcinoma(PDAC) remains a deadly disease due to the lack of early diagnostic tools and reliable therapeutic approaches. Consequently, a majority of patients(80%) display an advanced disease that results in a low resection rate leading to an overall median survival of less than 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are des-perately needed to help alleviate the dismal prognosis of this cancer. In addition, the discovery of new therapeutic targets is mandatory to design effective treatments. In this review, we will highlight the translational studies demonstrating that microRNAs may soon translate into clinical applications as long-awaited screening tools and therapeutic targets for PDAC. | Marion Gayral Sébastien Jo Naima Hanoun Alix Vignolle-Vidoni Hubert Lulka Yannick Delpu Aline Meulle Marlène Dufresne Marine Humeau Maёl Chalret du Rieu Barbara Bournet Janick Sèlves Rosine Guimbaud Nicolas Carrère Louis Buscail Jérome Torrisani Pierre Cordelier | 2014 | World Journal of Gastroenterology2014，20，32： | 4 |
| 5 | Orchestration of occludins, claudins, catenins and cadherins as players involved in maintenance of the blood-epididymal barrier in animals and humans显示文摘尽管精子在睾丸在精子发生期间被形成,阴囊的精子是不成熟的并且不能游泳或使肥沃。这些批评精子的功能在特定的钠环境被 theblood-epididymal 障碍创造的附睾被获得;附睾主细胞分泌的蛋白质把精子绑在成熟并且调整精子的 maturational 过程。在附睾, epithelialcell 房间相互作用被粘住的连接调停,为房间粘附必要,并且由紧密的连接,哪个形式 blood-epididymal 障碍。这些细胞的连接的规定被认为在在邻近的主细胞许可证之间的 epididymis.Tight 连接以内在精子成熟的过程代表一个关键决定因素在为精子成熟是必要的附睾的腔的特定的微型环境的形成。尽管我们成为了重要,在理解附睾功能和 blood-epididymal 障碍进行,用动物模型,人的附睾上有有限信息。如果我们将理解对人的附睾可归因的正常、病理学的条件工作,我们必须清楚地建立人的附睾的生理、细胞、分子的规定,描绘这些功能并且开发将使用 epididymalfunctions 到的临床的策略的 develop 工具改进不孕的处理。 | Daniel G. Cyr Mary Gregory Evemie Dube Julie Dufresne Peter T. K. Chan Louis Hermo | 2007 | Asian Journal of Andrology2007，9，4： | 3 |
| 6 | Development of a Direct Competitive Enzyme-Linked Immunosorbent Assay for the Detection of Fluoroquinolone Residues in Shrimp显示文摘 | Sheryl A. Tittlemier Jean-Marc Gélinas Guy Dufresne Mehul Haria Jessica Querry Chantal Cleroux Cathie Ménard Philippe Delahaut Gurmit Singh Nathalie Fischer-Durand Samuel Benrejeb Godefroy | 2008 | Food Analytical Methods2008，，1： | 2 |
| 7 | Toxicity of Benzotriazole and Benzotriazole Derivatives to Three Aquatic Species显示文摘 | David A Pillard Jeffrey S Cornell Doree L DuFresne Mark T Hernandez | 2000 | Water Research2000，，2： | 2 |
| 8 | 连续油管欠平衡水平井钻井在不列颠哥伦比亚省应用的优势显示文摘操作简易、安全和对储层的损害程度小是负压分隔碳酸岩储层,应用连续油管欠平衡水平井钻井的主要原因。 | Trevor Dufresne 王玉华 | 2006 | 吐哈油气2006，11，4： | 2 |
| 9 | Review of Cellulose Nanocrystal-based Fluorophore Materials and Their Application in Metal Ion Detection显示文摘Cellulose nanocrystals(CNCs), a unique and promising natural material extracted from native cellulose, have attracted considerable attention owing to their physical properties and special surface chemistry. This review focuses on chemical conjugation strategies that can be used for preparation of fluorescent-molecule labeled CNCs and the development of biomaterials.Furthermore, their application in the detection of metal ions and future development prospects are discussed. We hope to provide a clear view of the strategies for surface fluorescent modification of CNCs and their application in detection of metal ions. | Ya Wang Alain Dufresne Peter R. Chang XiaoZhou Ma Jin Huang | 2018 | Paper And Biomaterials2018，3，4： | 2 |
| 10 | Mechanism for Src activation by the CCK2 receptor:Patho-physiological functions of this receptor in pancreas显示文摘瞄准:调查在活体内, CCK2 受体(CCK2R ) 是否调整蛋白质,知道在房间增长和癌症开发和分析在试管内起一个关键作用导致 Src 激活的分子的机制;特别地,那在这激活被含有在 CCK2R 顺序以内识别领域。方法:Src 和英皇家空军之阶级最低之兵的表示和激活是学习在活体内使用免疫荧光和西方污点的技术。我们使用了从在胰腺的腺泡表示了 CCK2R 的野类型或 Elas-CCK2 老鼠导出的胰腺的纸巾,显示了增加的胰腺的生长并且开发了肿瘤前损害。短暂地表示内长的 CCK2R 或 COS-7 房间的胰腺的肿瘤房间线 AR4-2J 有野类型或变异的 CCK2R 的 transfected 被用作在试管内模型学习 Src 激活的机制。Src 激活被在试管内激酶试金测量,由用 anti-phospho-ERK 抗体和在由 MTT 的导致 gastrin 的房间增长的 Src 的参与的西方的污点的英皇家空军之阶级最低之兵激活测试。结果:我们出现了因为在 Elas-CCK2 鼠标的胰的指向的 CCK2R 表达式,导致了 Src 和 ERK 小径的激活。Src 被激活由在胰腺的弦音器的 CCK2R 的 ERK 小径在上游口头的房间并且贡献了增生的效果由这受体调停了。在试管内结果证明由 CCK2R 的 Src/ERK 小径的激活要求了 NPXXY 主题,在第 7 transmembrane 领域的结束在 CCK2R 顺序以内定位了,并且建议了在这机制的 Gq 的通常认为的角色。结论:由 CCK2R 的 Src/ERK 小径的解除管制可能代表贡献房间增长,肿瘤前损害的形成和胰腺的肿瘤开发的早步。 | Audrey Ferrand Sebastien Vatinel Aline Kowalski-Chauvel Claudine Bertrand Chantal Escrieut Daniel Fourmy Marlene Dufresne Catherine Seva | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 11 | Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells显示文摘瞄准:为了调查 Src, JAK2 和 phosphatidylinositol 3-kinase (PI3K ) 小径是否涉及人的结肠的瘤房间的增长,由扩大 glycine 的促胃液素导致了(G-gly ) ,先锋在 ated 促胃液素中并且到成熟阐明在响应这肽的这三家族 ases 之间的分子的相互作用。方法:用人的结肠的瘤,房间作为一个模型衬里 HCT116,我们首先测量了 PI3K, p60-Src 和 JAK2 的激活响应 G-gly 由在试管内激酶试金。然后,我们由 MTT 测试在 G-gly-induced 房间增长调查了这些家族 ases 的参与。结果:G-gly,刺激在 HCT116 导致了 p60-Src, JAK2 和 PI3K 激活。不同小径涉及房间导致了由的人的结肠癌的增长 G-gly。而且,我们发现 Src 和 JAK2 对由这肽的 PI3K 规定必要。然而,我们没发现在二酷氨酸家族 ases 之间的任何串音。结论:我们的结果建议 p60-Src/PI3K 和 JAK2/PI3K 小径独立地行动调停人的结肠的瘤房间上的 G-gly 增生的的效果。 | Audrey Ferrand Aline Kowalski-Chauvel Claudine Bertrand Daniel Fourmy Marlene Dufresne Catherine Seva Julie Pannequin | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 12 | Genome sequence of the cyanobacterium Prochlorococcus marinus SS120, a nearly minimal oxyphototro-phic genome 显示文摘 | Dufresne A Salanoubat M Partensky F | 2003 | Proc Natl Acad Sci USA2003，100，10： | 1 |
| 13 | Improvement of starch film performances using cellulose microfibrils显示文摘 | DUFRESNE A VIGNON M R | 1998 | Macromolecules1998，31，： | 1 |
| 14 | Block copoly- mer micelles : preparation, characterization and application in drug delivery 显示文摘 | Gaucher G Dufresne M H Sant V P | 2005 | J Controlled Release2005，109，123： | 1 |
| 15 | Review of recent research into cellulosic whiskers,their properties and their application in nanocomposite field显示文摘 | Samir M Alloin F Dufresne A | | 0，，2： | 1 |
| 16 | Cellulose whiskers versus microfibrils:Influence of the nature of the nanoparticle and its surface functionalization on the thermal and mechanical properties of nanocomposites显示文摘 | Siqueira G Bras J Dufresne A | 2008 | Biomacromolecules2008，10，2： | 1 |
| 17 | Effect of cross winds on high-speed trains: development of a new experimental methodology显示文摘 | Stéphane Sanquer Christian Barré Marc Dufresne de Virel Louis-Marie Cléon | 2004 | Journal of Wind Engineering & Industrial Aerodynamics2004，，： | 1 |
| 18 | Imatinib mesilate for the treatment of gastrointestinal stromal tumour显示文摘 | Cassier PA Dufresne A Arifi S | 2008 | Expert Opin Pharmacother2008，9，7： | 1 |
| 19 | Characterization of the textural properties of dealuminated HY forms显示文摘 | Raatz F Dufresne P | 1987 | Zeolites1987，7，： | 1 |
| 20 | Cellulose mi- erofibrils from potato tuber cells: processing and characteriza- tion of starch-cellulose mierofibril composites显示文摘 | DUFRESNE A DUPEYRE D VIGNON M R | 2000 | Appl Polym Sci2000，76，： | 1 |
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