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| 1 | Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。 | Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang | 2014 | Cell Research2014，24，2： | 244 |
| 2 | A study of local amplification effect of soil layers on ground motion in the Kathmandu Valley using microtremor analysis显示文摘Past researchers have anticipated the occurrence of a great earthquake in the central Himalayas in the near future.This may cause serious damage in the Kathmandu Valley,which sits on an ancient lake bed zone,with lacustrine sediments of more than 500 m depth.In this study,the predominant frequency of ground motion is evaluated using the Horizontal-to-Vertical(H/V) spectral ratio technique and recordings of ambient noise.The results of the H/V ratio show two peaks in about 20 percent of the locations,which are distributed mainly in and around the center and northern part of the Kathmandu Valley.The predominant frequencies vary from 0.5 Hz to 8.9 Hz in the study area,whereas the second resonance frequency varies from 4 Hz to 6 Hz in the center and northern part of the valley.This indicates that the center and northern part of the valley have a wide range of resonance frequency due to two levels of impedance contrast one may be from the surface layer and the other may be from the layer underneath.These two levels of resonance indicate the importance of considering the effects of surface and lower layers during the planning and designing of infrastructures in the Kathmandu Valley. | Paudyal Y.R. Yatabe R. Bhandary N.P. Dahal R.K. | 2012 | Earthquake Engineering and Engineering Vibration2012，11，2： | 7 |
| 3 | 经肛门Soave巨结肠根治术后排便功能的评价显示文摘目的观察经肛门Soave巨结肠根治术后排便功能和结肠切端缩口缝合术的效果。方法回顾性分析2003年10月至2008年10月130例经肛门Soave巨结肠根治术患儿的术后排便功能恢复情况。结果130例中98例行经肛门根治术,32例因长段型和直肠乙状结肠呈直筒状行腹腔镜协助经肛门根治术,其中15例因近端结肠切端扩张与肛门口径大小不符行结肠切端缩口缝合后再行肛门结肠吻合。130例术后电话和信件获访90例,远期并发症3例,其中污粪2例,便秘合并小肠结肠炎1例。对术后恢复时间达3年以上的56例患儿进行排便功能评分,评分为正常组有23例,优组31例,良组2例,无差组病例。行结肠切端缩口缝合术的15例患儿全部获访,排便功能评分正常组6例,优组9例,无并发症。结论经肛门Soave巨结肠根治术后长期肛门排便功能恢复满意。扩张但功能良好的近端结肠切端管径大于肛门口径时,可行结肠切端缩口缝合术。结肠切端缩口缝合术疗效确切,可与腹腔镜技术协同成为经肛门巨结肠手术的辅助手段。 | 郭立华 Geha Raj Dahal 杨合英 李苏宁 刘秋亮 张大 王家祥 | 2009 | 中华小儿外科杂志2009，，12： | 5 |
| 4 | Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated metaanalysis of randomized trials显示文摘BACKGROUND A few randomized clinical trials(RCT) and their meta-analyses have found patent foramen ovale closure(PFOC) to be beneficial in prevention of stroke compared to medical therapy. Whether the benefit is extended across all groups of patients remains unclear.AIM To evaluate the efficacy and safety of PFOC vs medical therapy in different groups of patients presenting with stroke, we performed this meta-analysis of RCTs.METHODS Electronic search of PubMed, EMBASE, Cochrane Central, CINAHL and ProQuest Central and manual search were performed from inception through September 2018 for RCTs. Ischemic stroke(IS), transient ischemic attack(TIA), a composite of IS, TIA and systemic embolism(SE), mortality, major bleeding,atrial fibrillation(AF) and procedural complications were the major outcomes.Random-effects model was used to perform analyses.RESULTS Meta-analysis of 6 RCTs including 3560 patients showed that the PFOC,compared to medical therapy reduced the risk of IS [odds ratio: 0.34; 95%confidence interval: 0.15-0.78; P = 0.01] and the composite of IS, TIA and SE [0.55(0.32-0.93); P = 0.02] and increased the AF risk [4.79(2.35-9.77); P < 0.0001]. No statistical difference was observed in the risk of TIA [0.86(0.54-1.38); P = 0.54],mortality [0.74(0.28-1.93); P = 0.53] and major bleeding [0.81(0.42-1.56); P = 0.53]between two strategies. Subgroup analyses showed that compared to medical therapy, PFOC reduced the risk of stroke in persons who were males, ≤ 45 years of age and had large shunt or atrial septal aneurysm.CONCLUSION In certain groups of patients presenting with stroke, PFOC is beneficial in preventing future stroke compared to medical therapy. | Khagendra Dahal Adil Yousuf Hussam Watti Brannen Liang Sharan Sharma Jharendra Rijal Pavan Katikaneni Kalgi Modi Neeraj TANDon Michael Azrin Juyong Lee | 2019 | World Journal of Cardiology2019，11，4： | 4 |
| 5 | Use of rotational atherectomy for reducing significant dissection in treating de novo femoropopliteal steno-occlusive disease after balloon angioplasty显示文摘动脉的解剖的 BackgroundDevelopment 被认为是为在 femoropopliteal 疾病的跳伞 stenting 的一个重要关键因素。我们试图与旋转 atherectomy 并且没有 it.MethodsFrom 2011年1月处于在处理组之间的解剖率和结果评估差别到2016年10月,我们在 de-novo 的汽球 angioplasty ( BA )以后比较了 angiography , femoropopliteal ,速闭塞的损害他们是否被旋转 atherectomy 在 BA 以前对待。59 损害(8 吸藏;3 包含的腿弯部的片断;损害长度:86.3 | Tae-Hoon Kim Manny Katsetos Khagendra Dahal Michael Azrin Juyong Lee | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 6 | Review on current concepts of myopia and its control strategies显示文摘Myopia poses a significant burden on the healthcare system,economy and quality of life.It is an emerging global public health challenge and requires interventions to delay or stop onset and progression.With changing times and evidence,the concepts of myopia are changing along with the treatment and control strategies.Behavioural modifications including increased outdoors time and reduced near work,optical and pharmaceutical management options are reviewed.This paper presents a current overview on the concepts of myopia,and is expected to summarize updates on myopia control methods. | Raju Kaiti Ranjila Shyangbo Indra Prasad Sharma Manish Dahal | 2021 | International Journal of Ophthalmology(English edition)2021，14，4： | 3 |
| 7 | 高等院校护理专业学生对人文关怀感知的调查显示文摘目的了解在校护生人文关怀感知现况,为针对性干预提供参考。方法对600名在校护生采用自制的护生人文关怀感知问卷进行调查分析。结果人文关怀感知总分为4.03±0.59,其中同伴关怀维度得分最高(4.17±0.67)、环境关怀维度得分最低(3.84±0.74);是否独生子女、不同学历及不同年级护生人文关怀感知得分差异有统计学意义(P<0.05,P<0.01)。结论在校护生人文关怀感知总体较好,但感知的校园环境关怀较低。非独生子女、本科及其高年级护生感知的人文关怀水平更低。应加强针对性建设和培养,以改善护理院校人文关怀环境和护生感知度。 | 王洁玉 Sanuja Dahal 刘义兰 张可可 张红菱 魏翩 郭慧玲 张丰健 毛靖 徐晖 | 2021 | 护理学杂志2021，36，16： | 3 |
| 8 | An Investigation of Landslide Susceptibility Using Logistic Regression and Statistical Index Methods in Dailekh District, Nepal显示文摘Landslide distribution and susceptibility mapping are the fundamental steps for landslide-related hazard and disaster risk management activities, especially in the Himalaya region which has resulted in a great deal of death and damage to property. To better understand the landslide condition in the Nepal Himalaya, we carried out an investigation on the landslide distribution and susceptibility using the landslide inventory data and 12 different contributing factors in the Dailekh district, Western Nepal. Based on the evaluation of the frequency distribution of the landslide, the relationship between the landslide and the various contributing factors was determined.Then, the landslide susceptibility was calculated using logistic regression and statistical index methods along with different topographic(slope, aspect, relative relief, plan curvature, altitude, topographic wetness index) and non-topographic factors(distance from river, normalized difference vegetation index(NDVI), distance from road, precipitation, land use and land cover, and geology), and 470(70%) of total 658 landslides. The receiver operating characteristic(ROC) curve analysis using 198(30%) of total landslides showed that the prediction curve rates(area under the curve, AUC) values for two methods(logistic regression and statistical index) were 0.826, and 0.823with success rates of 0.793, and 0.811, respectively. The values of R-Index for the logistic regression and statistical index methods were83.66 and 88.54, respectively, consisting of high susceptible hazard classes. In general, this research concluded that the cohesive and coherent natural interplay of topographic and non-topographic factors strongly affects landslide occurrence, distribution, and susceptibility condition in the Nepal Himalaya region. Furthermore, the reliability of these two methods is verified for landslide susceptibility mapping in Nepal’s central mountain region. | DIL Kumar RAI XIONG Donghong ZHAO Wei ZHAO Dongmei ZHANG Baojun NIRMAL Mani DAHAL WU Yanhong MUHAMMAD Aslam BAIG | 2022 | Chinese Geographical Science2022，32，5： | 2 |
| 9 | Coronary vasospasm:A narrative review显示文摘Coronary artery vasospasm(CAVS)plays an important role in acute chest pain syndrome caused by transient and partial or complete occlusion of the coronary arteries.Pathophysiology of the disease remains incompletely understood,with autonomic and endothelial dysfunction thought to play an important role.Due to the dynamic nature of the disease,its exact prevalence is not entirely clear but is found to be more prevalent in East Asian and female population.Cigarette smoking remains a prominent risk factor,although CAVS does not follow traditional coronary artery disease risk factors.Many triggers continue to be identified,with recent findings identifying chemotherapeutics,allergens,and inflammatory mediators as playing some role in the exacerbation of CAVS.Provocative testing with direct visualization is currently the gold-standard for diagnosis,but non-invasive tests,including the use of biomarkers,are being increasingly studied to aid in the diagnosis.Treatment of the CAVS is an area of active research.Apart from risk factor modification,calcium channel blockers are currently the first line treatment,with nitrates playing an important adjunct role.High-risk patients with life-threatening complications should be considered for implantable cardioverter defibrillator(ICD),although timing criteria for escalated therapy require further investigation.The role of pharmaceuticals targeting oxidative stress remains incompletely understood. | Jacob Jewulski Sumesh Khanal Khagendra Dahal | 2021 | World Journal of Cardiology2021，13，9： | 2 |
| 10 | Two tomato expansin genes show divergent expression and localization in embryos during seed development and germination显示文摘 | Chen F Dahal P Bradford K J | 2001 | Plant Physiology2001，127，： | 1 |
| 11 | Spatiotemporal analysis of drought variability based on the standardized precipitation evapotranspiration index in the Koshi River Basin, Nepal显示文摘Drought is an inevitable condition with negative impacts in the agricultural and climatic sectors,especially in developing countries.This study attempts to examine the spatial and temporal characteristics of drought and its trends in the Koshi River Basin(KRB)in Nepal,using the standardized precipitation evapotranspiration index(SPEI)over the period from 1987 to 2017.The Mann-Kendall test was used to explore the trends of the SPEI values.The study illustrated the increasing annual and seasonal drought trends in the KRB over the study period.Spatially,the hill region of the KRB showed substantial increasing drought trends at the annual and seasonal scales,especially in summer and winter.The mountain region also showed a significant increasing drought trend in winter.The drought characteristic analysis indicated that the maximum duration,intensity,and severity of drought events were observed in the KRB after 2000.The Terai region presented the highest drought frequency and intensity,while the hill region presented the longest maximum drought duration.Moreover,the spatial extent of drought showed a significant increasing trend in the hill region at the monthly(drought station proportion of 7.6%/10 a in August),seasonal(drought station proportion of 7.2%/10 a in summer),and annual(drought station proportion of 6.7%/10 a)scales.The findings of this study can assist local governments,planners,and project implementers in understanding drought and developing appropriate mitigation strategies to cope with its impacts. | Nirmal M DAHAL XIONG Donghong Nilhari NEUPANE Belayneh YIGEZ ZHANG Baojun YUAN Yong Saroj KOIRALA LIU Lin FANG Yiping | 2021 | Journal of Arid Land2021，13，5： | 1 |
| 12 | InGaN/GaN multiple quantum well solar cells with long operating wave- lengths显示文摘 | Dahal R Pantha B Li J | 2009 | Applied Physics Letters2009，94，06： | 1 |
| 13 | Diatoms as indicatom of stream quality in the Kathmandu Valley and Middle Hills of Nepal and India 显示文摘 | Juttner I Sharma S Dahal B M | 2003 | Freshwater Biology2003，48，11： | 1 |
| 14 | A comparative evaluation of hexavalent chromium treatment in contaminated soil by calcium polysulfide and green-tea nanoscale zero-valent iron 显示文摘 | Chrysochoou M Johnston C P Dahal G | 2012 | Journal of Hazardous Materials2012，02，： | 1 |
| 15 | Generator maintenance scheduling in power systems using metaheuristic-based hybrid approaches 显示文摘 | DAHAL K P CHAKPITAK N | 2007 | Electric Power Systems Research2007，77，7： | 1 |
| 16 | Biochemical and nutritional evaluation of Masyaura-A legume based traditional savory of Nepal显示文摘 | Dahal N R Rao E R Swamylingappa B | 2003 | JFood Sci Technol2003，40，1： | 1 |
| 17 | The effects of aldosterone antagonists in pa-tients with resistant hypertension : a meta-analysis of randomized and nonran-domized studies显示文摘 | Dahal K Kunwar S Rijal J | 2015 | Am J Hypertens2015，28，11： | 1 |
| 18 | Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation显示文摘 | Raes G Brys L Dahal BK | 2004 | J Leukoc Biol2004，77，3： | 1 |
| 19 | Synthesis of water-soluble iron-gold alloy nanoparticles显示文摘 | Dahal N Chikan V Jasinski J | 2008 | Chem Mater2008，20，： | 1 |
| 20 | Long-term outcome of children after single-stage transanal endorectal pull-through for Hirschsprung's disease显示文摘 | Dahal GR Wang JX Guo LH | | 0，，01： | 1 |
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