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| 1 | Large vestibular aqueduct syndrome:a genetic disease?显示文摘 | TONG K A HARNSBERGER H R DAHLEN R T | 1997 | AJR Am J Roentgenol1997，168，4： | 1 |
| 2 | CoppeR deficiency increases fibulin-5 but decreases cytochrome C oxidase VIb subunit expression in rat heart显示文摘 | Zeng H Saari J T Dahlen G M | 2006 | J lnorg Biochem2006，100，2： | 1 |
| 3 | High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthma 显示文摘 | Vachier I Kumlin M Dahlen SE Bousquet T Godard P Chanez P | 2003 | Respir Med2003，97，11： | 1 |
| 4 | 2,5 - Dimethyl-4- hydroxy -3 (2H)--Furanone as a Secondary Metabolite from D-Fructose- 1,6-Diphosphate Metabolism by Zygosaccharomyces rouxii 显示文摘 | Dahlen T Hauck T Wein M | 2001 | Journal of Bioscience and Bioengineering2001，91，4： | 1 |
| 5 | Characterization of Bacteroides forsythus isolates显示文摘 | Takemoto T Kurihara H Dahlen G | 1997 | J Clin Microbiol1997，35，： | 1 |
| 6 | Microbiological evaluation ofone-and two-visit endodontic treatment of teeth with apical peri-odontitis:a randomized,clinical trial显示文摘 | Kvist T Molander A Dahlen G | 2004 | J Endod2004，30，8： | 1 |
| 7 | Overlapping thin section fast spin-echo MR of the large vestibular aqueduct syndrome显示文摘 | Dahlen R T Harsberger H R Gray S D | 1997 | AJNR1997，18，1： | 1 |
| 8 | Characterization of Bacteroides forsythus isolates显示文摘 | Takemoto T Kurihara H Dahlen G | 1997 | J Clin Microbiol1997，35，： | 1 |
| 9 | Carotid inti- ma-media thickness and apolipoprotein B/apolipoprotein A-I ratio in middle-aged patients with Type 2 diabetes 显示文摘 | DAHLEN E M LANNE T ENGVALL J | 2009 | Diabetic Medicine2009，26，4： | 1 |
| 10 | CT and MR imaging characteristics of intravestibular lipoma 显示文摘 | Dahlen R T Johnson C E Harnsberger H R | 2002 | AJNR2002，23，8： | 1 |
| 11 | Dislocation fractures in the area of the middle foot:Injuries of the Chopart and Lisfranc joint显示文摘 | Randt T Dahlen C Schikore H | 1998 | Zentralbl Chir1998，，123： | 1 |
| 12 | Overlapping thin-section fast spin-echo MR of the large vestibular aqueduct syndrome显示文摘 | Dahlen R T Harnsberger H R Gray S D | 1997 | AJNR1997，18，2： | 1 |
| 13 | Carotid intima-media thickness and apolipoprotein B/apolipoprotein A-I ratio in middle-aged patients with Type 2 diabetes显示文摘 | Dahlen E M Lanne T Engvall J | 2009 | Diabetic Medicine2009，26，4： | 1 |
| 14 | Microbiological evaluation of one-and two-visit endodontic treatment of teeth with apical periodontitis:a randomized,clinical trial显示文摘 | Kvist T Molander A Dahlen G | 2004 | J Endod2004，30，8： | 1 |
| 15 | Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes 显示文摘 | Dahlen EM Tengblad A Lanne T | 2014 | Diabetes Metab2014，40，1： | 1 |
| 16 | 2, 5-Dimethyl-4-Hydroxy-3 (2H)-furanone as a secondary metabolite from D-fructose-1, 6-diphosphate metabolism by Zygosaccharomyces rouxii 显示文摘 | DAHLEN T HAUCK S WEIN M | 2001 | J Biosci Bioeng2001，91，4： | 1 |
| 17 | Overlap- ping thin - section fast spin - echo MR of the large vestib- ular aqueduct syndrome 显示文摘 | Dahlen R T Hamsberger H R Gray S D | 1997 | AJNR Am J Neuroradiol1997，18，1： | 1 |
| 18 | Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C显示文摘AIM To characterize the role of apolipoprotein B100(apoB 100) in hepatitis C viral(HCV) infection. METHODS In this study, we utilize a gene editing tool, transcription activator-like effector nucleases(TALENs), to generate human hepatoma cells with a stable genetic deletion of APOB to assess of apoB in HCV. Using infectious cell culture-competent HCV, viral pseudoparticles, replicon models, and lipidomic analysis we determined the contribution of apoB to each step of the viral lifecycle. We further studied the effect of mipomersen, an FDAapproved antisense inhibitor of apoB 100, on HCV using in vitro cell-culture competent HCV and determined itsimpact on viral infectivity with the TCID50 method. RESULTS We found that apo B100 is indispensable for HCV infection. Using the JFH-1 fully infectious cell-culture competent virus in Huh 7 hepatoma cells with TALENmediated gene deletion of apoB(APOB KO), we found a significant reduction in HCV RNA and protein levels following infection. Pseudoparticle and replicon models demonstrated that apo B did not play a role in HCV entry or replication. However, the virus produced by APOB KO cells had significantly diminished infectivity as measured by the TCID-50 method compared to wildtype virus. Lipidomic analysis demonstrated that these virions have a fundamentally altered lipidome, with complete depletion of cholesterol esters. We further demonstrate that inhibition of apoB using mipomersen, an FDA-approved anti-sense oligonucleotide, results in a potent anti-HCV effect and significantly reduces the infectivity of the virus. CONCLUSION Apo B is required for the generation of fully infectious HCV virions, and inhibition of apo B with mipomersen blocks HCV. Targeting lipid metabolic pathways to impair viral infectivity represents a novel host targeted strategy to inhibit HCV. | Esperance AK Schaefer James Meixiong Christina Mark Amy Deik Daniel L Motola Dahlene Fusco Andrew Yang Cynthia Brisac Shadi Salloum Wenyu Lin Clary B Clish Lee F Peng Raymond T Chung | 2016 | World Journal of Gastroenterology2016，22，45： | 1 |
| 19 | 2, 5-Dimethyl-4-hydroxy-3 (2H)-Furanone as a Secondary Metabolite from D-Fructose-1,6-Diphosphate Metabolism by Zygosaccharomyces rouxii 显示文摘 | DAHLEN T HAUCK T WEIN M | 2001 | J Biosci Bioeng2001，91，4： | 1 |
| 20 | Large vestibularaqueduct syndrome:a genetic disease?显示文摘 | Tong K A Hamsberger H R Dahlen R T | 1997 | AJR Am J Roentgenol1997，168，4： | 1 |
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