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| 1 | Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease显示文摘Mesenchymal stem cells(MSCs) have been used to treat patients suffering from acute myocardial infarction(AMI) and subsequent heart failure. Although it was originally assumed that MSCs differentiated into heart cells such as cardiomyocytes, recent evidence suggests that the differentiation capacity of MSCs is minimal and that injected MSCs restore cardiac function via the secretion of paracrine factors. MSCs secrete paracrine factors in not only naked forms but also membrane vesicles including exosomes containing bioactive substances such as proteins, messenger RNAs, and microR NAs. Although the details remain unclear, these bioactive molecules are selectively sorted in exosomes that are then released from donor cells in a regulated manner. Furthermore, exosomes are specifically internalized by recipient cells via ligand-receptor interactions. Thus, exosomes are promising natural vehicles that stably and specifically transport bioactive molecules to recipient cells. Indeed, stem cell-derived exosomes have been successfully used to treat cardiovascular disease(CVD), such as AMI, stroke, and pulmonary hypertension, in animal models, and their efficacy has been demonstrated. Therefore, exosome administration may be a promising strategy for the treatment of CVD. Furthermore, modifications of exosomal contents may enhance their therapeutic effects. Future clinical studies are required to confirm the efficacy of exosome treatment for CVD. | Etsu Suzuki Daishi Fujita Masao Takahashi Shigeyoshi Oba Hiroaki Nishimatsu | 2016 | World Journal of Stem Cells2016，8，9： | 19 |
| 2 | Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease显示文摘Adipose tissue-deried stem cells( ADSCs) are adult stem cells that can be easily harvested from subcutaneous adipose tissue. Many studies have demonstrated that ADSCs differentiate into vascular endothelial cells(VECs), vascular smooth muscle cells(VSMCs), and cardiomyocytes in vitro and in vivo. However, ADSCs may fuse with tissue-resident cells and obtain the corresponding characteristics of those cells. If fusion occurs, ADSCs may express markers of VECs, VSMCs, and cardiomyocytes without direct differentiation into these cell types. ADSCs also produce a variety of paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor-1 that have proangiogenic and/or antiapoptotic activities. Thus, ADSCs have the potential to regenerate the cardiovascular system via direct differentiation into VECs, VSMCs, and cardiomyocytes, fusion with tissueresident cells, and the production of paracrine factors. Numerous animal studies have demonstrated the efficacy of ADSC implantation in the treatment of acute myocardial infarction(AMI), ischemic cardiomyopathy(ICM), dilated cardiomyopathy, hindlimb ischemia, and stroke. Clinical studies regarding the use of autologous ADSCs for treating patients with AMI and ICM have recently been initiated. ADSC implantation has been reported as safe and effective so far. Therefore, ADSCs appear to be useful for the treatment of cardiovascular disease. However, the tumorigenic potential of ADSCs requires careful evaluation before their safe clinical application. | Etsu Suzuki Daishi Fujita Masao Takahashi Shigeyoshi Oba Hiroaki Nishimatsu | 2015 | World Journal of Cardiology2015，7，8： | 17 |
| 3 | Abundance and distribution of ammonia-oxidizing archaea in Tibetan and Yunnan plateau agricultural soils of China显示文摘同样低的氧和高度紫外(紫外) 暴露可能显著地在高原影响微生物引起的存在,它能导致一个专业化微生物引起的社区。在高原的农业土壤决定氧化氨的 archaea (AOA ) 的丰富和分发,七件土壤样品从在栽培小麦,高地大麦,和菜子的西藏和云南的农田分别地是镇定的,它在上面的 32003800 m 的高度被定位海水平。量的 PCR (q-PCR ) 并且克隆图书馆在 amoA 基因上指向被用来确定许多 AOA 和氧化氨的细菌(AOB ) ,并且在样品描绘 AOA 的社区结构。AOA 房间的数字(9.34 敤潶牵摥? | Kun DING Xianghua WEN Liang CHEN Daishi HUANG Fan FEI Yuyang LI | 2014 | Frontiers of Environmental Science & Engineering2014，8，5： | 2 |
| 4 | Inhibition of EG- FR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord in- jury显示文摘 | Qu Wensheng Tian Daishi Guo Zhibao | 2012 | J Neuroinflammation2012，9，： | 1 |
| 5 | In- fluence of calcination temperature on the surface acid- ity of the solid superacid of sulfated alumina 显示文摘 | Hiromi Matsuhashi Daishi Sato Kazushi Arata | 2004 | React Kinet Catal Lett2004，81，1： | 1 |
| 6 | GC-MS and IR spectroscopic analyses of the lignin-derived products from softwood and hardwood treated in supercritical water显示文摘 | Katsunobu E Daishi E Shiro E | 2004 | Journal of Wood Science2004，51，3： | 1 |
| 7 | Boophilus microplus tick larvae,a rich source of Kunitz type serine proteinase inhibitors显示文摘 | Sergio Daishi Sasaki Simone Sant'Anna Azzolini Izaura Yoshico Hirata | 2004 | Biochimie2004，86，： | 1 |
| 8 | Adult stem cells as a tool for kidney regeneration显示文摘Kidney regeneration is a challenging but promising strategy aimed at reducing the progression to end-stage renal disease(ESRD) and improving the quality of life of patients with ESRD. Adult stem cells are multipotent stem cells that reside in various tissues, such as bone marrow and adipose tissue. Although intensive studies to isolate kidney stem/progenitor cells from the adult kidney have been performed, it remains controversial whether stem/progenitor cells actually exist in the mammalian adult kidney. The efficacy of mesenchymal stem cells(MSCs) in the recovery of kidney function has been demonstrated in animal nephropathy models, such as acute tubular injury, glomerulonephritis, renal artery stenosis, and remnant kidney. However, their beneficial effects seem to be mediated largely via their paracrine effects rather than their direct differentiation into renal parenchymal cells. MSCs not only secrete bioactive molecules directly into the circulation, but they also release various molecules, such as proteins, m RNA, and micro RNA, in membrane-covered vesicles. A detailed analysis of these molecules and an exploration of the optimal combination of these molecules will enable the treatment of patients with kidney disease without using stem cells. Another option for the treatment of patients with kidney disease using adult somatic cells is a direct/indirect reprogramming of adult somatic cells into kidney stem/progenitor cells. Although many hurdles still need to be overcome, this strategy will enable bona fide kidney regeneration rather than kidney repair using remnant renal parenchymal cells. | Etsu Suzuki Daishi Fujita Masao Takahashi Shigeyoshi Oba Hiroaki Nishimatsu | 2016 | World Journal of Nephrology2016，5，1： | 1 |
| 9 | Combustion synthesis of porous TiC/Ti composite by a selfpropagating mode 显示文摘 | Makoto Kobashi Daishi Ichioka Naoyuki Kanetake | 2010 | Materials2010，3，： | 1 |
| 10 | Marked Spherocytosis in Clostridal Sepsis显示文摘 | Tetsuo Shoda Minoru Yoshimura Daishi Hayata Yoshio Miyazawa Kiyoyuki Ogata | 2006 | International Journal of Hematology2006，，2： | 1 |
| 11 | Influence of calcination temperature on the surface acidity of the solid superacid of sulfated alumina显示文摘 | Hiromi M Daishi S Kazushi A | 2004 | Reaction Kinetics Catalysis Letters2004，81，1： | 1 |
| 12 | Infl-uence of calcination temperature on the surface acidity of the solid superacid of sulfated alumina显示文摘 | Hiromi Matsuhashi Daishi Sato Kazushi Arata | 2004 | React Kinet Catal Lett2004，81，1： | 1 |
| 13 | Preventive Effects of Curcumin on the Development of Azoxymethane-Induced Colonic Preneoplastic Lesions in Male C57BL/KsJ-db/db Obese Mice显示文摘 | Masaya Kubota Masahito Shimizu Hiroyasu Sakai Yoichi Yasuda Daishi Terakura Atsushi Baba Tomohiko Ohno Hisashi Tsurumi Takuji Tanaka Hisataka Moriwaki | 2012 | Nutrition and Cancer2012，，1： | 1 |
| 14 | 探访海中猎人 正在消失的日本海女故事显示文摘她们,是自由潜水的先驱之一,在没有潜水镜、呼吸管和脚蹼的情况下,依旧可以温柔、坚定地纵身入海,在波澜壮阔的大海中讨生活;可如今,依海为生变得日益艰难,她们的人数逐年递减,这个古老的职业被迫走向消失……海女,是指不带辅助装备、只身潜入浅海捕捞龙虾、扇贝、鲍鱼、海螺等海产品的女性,这个职业在日本已有上千年历史。她们生长在海边,依靠下海捕捞为生,形成了一套独特的工作、生活习惯以及信仰,同时也造就了日本的海女文化。 | 康乃珥 Daishi Naruse(图) blue ruin(图) Roderick Eime(图) banzainetsurfer A(图) | 2020 | 环球人文地理2020，，7： | 0 |
| 15 | Histone deacetylases in hearing loss: Current perspectives for therapy显示文摘Hearing loss is one of the most frequent health issues in industrialized countries. The pathogenesis and molecular mechanisms of hearing loss are still unclear. Histone deacetylases(HDACs) are emerging as key enzymes in many physiological processes, including chromatin remodeling,regulation of transcription, DNA repair, metabolism, genome stability and protein secretion. Recent studies indicated that HDACs are associated with the development and progression of hearing loss. Dysfunction of HDACs could promote the oxidative stress and aging in the inner ear. In light of considering the current stagnation in the development of therapeutic options, the need for new strategies in the treatment of hearing loss has never been so pressing. In this review, we will summarize the reported literatures for HDACs in hearing loss and discuss how HDAC family members show different performances for the possibility of process of diseases development. The possibility of pharmacological intervention on hearing loss opens a novel path in the treatment of hearing loss. | Daishi Chen Ming Xu Beibei Wu Lei Chen | 2017 | Journal of Otology2017，12，2： | 0 |
| 16 | Effect of hydrogen peroxide on selective flotation of chalcocite and enargite显示文摘Enargite is typically associated with chalcocite.Owing to the similarity in the flotation behaviors of these minerals,both minerals are reported to concentrate in the conventional flotation circuit.However,inorganic arsenic in enargite can decrease the copper concentrate quality and increase the operating cost of processing this concentrate.Separating these minerals is important for cleaner copper production to avoid these effects.In this context,this study investigated the effect of hydrogen peroxide(H_(2)O_(2))treatment on the flotation behavior of chalcocite and enargite.Flotation tests of pure and mixed minerals indicated that H_(2)O_(2)treatment reduced the floatability of chalcocite and enargite by forming sulfate and copper hydroxide on their surfaces.Despite the detrimental effect of the H_(2)O_(2)treatment,there was a narrow window of H_(2)O_(2)concentration for separating both minerals,in which enargite floated and chalcocite was depressed.This selective flotation behavior was caused by the rapid adsorption of potassium amyl xanthate(KAX)and lower surface oxidation of enargite compared with that of chalcocite. | Gde Pandhe Wisnu Suyantara Daniyarov Berdakh Hajime Miki Tsuyoshi Hirajima Keiko Sasaki Daishi Ochi Yuji Aoki | 2023 | International Journal of Mining Science and Technology2023，33，6： | 0 |
| 17 | Preparation and characterization of SO_(4)^(2−)−/TiO_(2)and S_(2)O_(8)^(2)−/TiO_(2) catalysts显示文摘Nanosized solid superacids SO_(4)^(2−)/TiO_(2)and S_(2)O_(8)^(2)−/TiO_(2),as well as MCM-41-supported SO_(4)^(2−)/ZrO_(2),were prepared.Their structures,acidities,and catalytic activities were investigated and compared using XRD,N2 adsorption-desorption,and in situ FTIR-pyridine adsorption,as well as an evaluation reaction with pseudoionone cyclization.The results showed that SO_(4)^(2−)/TiO_(2)and S_(2)O_(8)^(2)−/TiO_(2)possess not only nanosized particles with diameters<7.0 nm,a BET sur-face greater than 140 cm2/g and relatively regular mesostruc-tures with pores around 4.0 nm,but also a pure anatase phase and strong acidity.Different from the Lewis acid nature of SO_(4)^(2−)/ZrO_(2)/MCM-41,SO_(4)^(2−)/TiO_(2)and S_(2)O_(8)^(2)−/TiO_(2)exhibit mainly Brønsted acidities.The strongest Brønsted acid sites were produced on SO_(4)^(2−)/TiO_(2)promoted with H2SO4,while Lewis acid sites on S_(2)O_(8)^(2)−/TiO_(2)even stronger than those on SO_(4)^(2−)/ZrO_(2)/MCM-41 were generated when persulfate solu-tion was used as sulfating agent.Because of their distinct acid natures,SO_(4)^(2−)/TiO_(2)and S_(2)O_(8)^(2)−/TiO_(2)exhibited catalytic activities for the cyclization of pseudoionone that were much higher than that of SO_(4)^(2−)/ZrO_(2)/MCM-41.It can be concluded that the existence of more Brønsted acid sites was favorable for proton participation in the cyclization reaction. | MA Xuedan GUO Daishi JIANG Qizhong MA Zifeng MA Zhengfei YE Weidong LI Chunbo | 2007 | Frontiers of Chemical Science and Engineering2007，1，1： | 0 |
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