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| 1 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Survival and outcomes for co-infection of chronic hepatitis C with and without cirrhosis and COVID-19: A multicenter retrospective study显示文摘BACKGROUND Chronic liver disease,particularly cirrhosis,is associated with worse outcomes in patients infected with coronavirus disease 2019(COVID-19).AIM To assess outcomes of COVID-19 infection among patients with pre-existing hepatitis C with or without liver cirrhosis.METHODS This multicenter,retrospective cohort study included all cases of confirmed coinfection of severe acute respiratory syndrome coronavirus 2 and chronic hepatitis C with or without liver cirrhosis who were admitted to six hospitals(Al-Sahel Hospital,Al-Matareya Hospital,Al-Ahrar Hospital,Ahmed Maher Teaching Hospital,Al-Gomhoreya Hospital,and the National Hepatology and Tropical Medicine Research Institute)affiliated with the General Organization for Teaching Hospitals and Institutes in Egypt.Patients were recruited from May 1,2020,to July 31,2020.Demographic,laboratory,imaging features,and outcomes were collected.Multivariate regression analysis was performed to detect factors affecting mortality.RESULTS This retrospective cohort study included 125 patients with chronic hepatitis C and COVID-19 co-infection,of which 64(51.20%)had liver cirrhosis and 40(32.00%)died.Fever,cough,dyspnea,and fatigue were the most frequent symptoms in patients with liver cirrhosis.Cough,sore throat,fatigue,myalgia,and diarrhea were significantly more common in patients with liver cirrhosis than in noncirrhotic patients.There was no difference between patients with and without cirrhosis regarding comorbidities.Fifteen patients(23.40%)with liver cirrhosis presented with hepatic encephalopathy.Patients with liver cirrhosis were more likely than non-cirrhotic patients to have combined ground-glass opacities and consolidations in CT chest scans:28(43.75%)vs 4(6.55%),respectively(P value<0.001).These patients also were more likely to have severe COVID-19 infection,compared to patients without liver cirrhosis:29(45.31%)vs 11(18.04%),respectively(P value<0.003).Mortality was higher in patients with liver cirrhosis,compared to those with no cirrhosis:33(51.56%)vs 9(14.75%),respectively(P value<0.001).All patients in Child-Pugh class A recovered and were discharged.Cirrhotic mortality occurred among decompensated patients only.A multivariate regression analysis revealed the following independent factors affecting mortality:Male gender(OR 7.17,95%CI:2.19–23.51;P value=0.001),diabetes mellitus(OR 4.03,95%CI:1.49–10.91;P value=0.006),and liver cirrhosis(OR 1.103,95%CI:1.037–1.282;P value<0.0001).We found no differences in liver function,COVID-19 disease severity,or outcomes between patients who previously received direct-acting antiviral therapy(and achieved sustained virological response)and patients who did not receive this therapy.CONCLUSION Patients with liver cirrhosis are susceptible to higher severity and mortality if infected with COVID-19.Male gender,diabetes mellitus,and liver cirrhosis are independent factors associated with increased mortality risk. | Shimaa Afify Basem Eysa Fatma Abdel Hamid Omnia M Abo-Elazm Mohamed A Edris Rabab Maher Ahmed Abdelhalim Muhammad Mostafa Abdel Ghaffar Dalia A Omran Hend Ibrahim Shousha | 2021 | World Journal of Gastroenterology2021，27，42： | 2 |
| 4 | Effects of the spin trap agent disodium benzene-1,3-disulfonate N-oxide on intracerebtal hemorrhage in a rabbit Large clot embolic stroke model:combination studies with tissue plasminogen activator显示文摘 | Paul A Dalia M Donghuan S | 2002 | Stroke2002，33，： | 1 |
| 5 | Versatility of choline metabolism and choline-binding proteins in streptococcus pneu- monia and commensal streptococci 显示文摘 | Regine H Abderrahim M Dalia D | 2009 | FEMS Microbiol Rev2009，33，3： | 1 |
| 6 | Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes显示文摘 | M Dalia Vestra Mussap M Galiina P | 2005 | Journal of the American Society of Nephrology2005，16，3： | 1 |
| 7 | Susceptibility of aged mice to Staphylococcus aureus keratitis显示文摘 | Girgis Dalia O Sloop Gregory D Reed Julian M | 2004 | Current Eye Research2004，29，45： | 1 |
| 8 | Rapid liquid chromatographic analysis of chlorothalonil in fresh produce using photoconductivity and UV detectors in tandem显示文摘 | Dalia M G Stephen M W | 1988 | J Agric Food Chem1988，36，： | 1 |
| 9 | Effect ofabdominal versus pelvic floor muscle exercises in obese Egyptianwomen with mild stress urinary incontinence : A randomised con-trolled trial显示文摘 | Dalia M Kamel Ali A Thabet Sayed A Tantawy | 2013 | Hong Kong Physiotherapy Journal2013，，6： | 1 |
| 10 | Comprehensive risk assessment of heavy metals in surface sediments along the Egyp- tian Red Sea coast显示文摘 | Dalia M S A S Azza K Ahmed E N | 2014 | The Egyptian Journal of Aquatic Research2014，40，4： | 1 |
| 11 | Pectolytic Activity by the Haustorium of the Parasitic Plant Orobanche L. (Orobanchaceae) in Host Roots显示文摘 | DALIA LOSNER-GOSHEN VITALY H PORTNOY ALFRED M MAYER DANIEL M JOEL | 1998 | Annals of Botany1998，，2： | 1 |
| 12 | Temperature responses of carbon mineralization in conifer forest soils from different regional climates incubated under standard laboratory conditions显示文摘 | Dalias P Anderson J M Bottner P | 2001 | Global Change Biology2001，6，： | 1 |
| 13 | In vitro culture of Orobancheaegyptiaca显示文摘 | GRAHAM B N DALIA L DANIEL M J | 1991 | Annals of Botany1991，68，： | 1 |
| 14 | Temperature responses of net nitrogen mineralization and nitrification in conifer forest soils incubated under standard laboratory conditions显示文摘 | Anderson J M Bottner P | 2002 | Soil Biology & Biochemistry2002，34，： | 1 |
| 15 | Role of endoscopic ultrasound and endoscopic ultrasound-guided tissue acquisition in diagnosing hepatic focal lesions显示文摘BACKGROUND Endoscopic ultrasonography(EUS)has become an established method in diagnostic and therapeutic procedures in gastroenterology;however,it has recently gained a growing role in hepatology.AIM To evaluate the role of EUS features,strain elastography(SE),and EUS-tissue acquisition in diagnosing hepatic focal lesions(HFLs)that could affect further management.METHODS This cross-sectional study included 215 patients with pancreatic,biliary,or gastrointestinal malignancies referred for EUS examination.HFLs were identified in 43 patients(20%),and EUSguided tissue acquisition was performed from these lesions.RESULTS EUS features were highly sensitive(100%)but much less specific(57%)in diagnosing HFLs;the overall accuracy was 94%.Real-time elastography was also very sensitive(97%)but less specific(67%)in diagnosing HFLs;however,the overall accuracy was 92%.EUS tissue acquisition was extremely sensitive(100%)and specific(100%),with a 100%overall diagnostic accuracy.CONCLUSION The diagnostic utility of EUS-guided tissue acquisition was extremely accurate in diagnosing HFLs.EUS characteristics and real-time SE accurately predicted the histological diagnosis of both benign and malignant HFLs. | Hussein Hassan Okasha Hanane Delsa Abdelmoneim Alsawaf Ahmed Morad Hashim Hani M Khattab Dalia Abdelfatah Abeer Abdellatef Amr Albitar | 2023 | World Journal of Methodology2023，13，4： | 1 |
| 16 | Long-term effects of temperature on carbon mineralization processes显示文摘 | DALIAS P ANDERSON J M BOTTNER P | 2001 | Soil Biology and Biochemistry2001，33，78： | 1 |
| 17 | A point mutation in translation initiation factor 2B leads to a continuous hyper stress state in oligodendroglial-derived cells 显示文摘 | Liraz K Dalia P Michelle M | 2008 | PLoS ONE2008，3，： | 1 |
| 18 | Temperature responses of net N mineralization and nitrification in conifer forest soils incubated under standard laboratory conditions显示文摘 | Dalias P Anderson J M Bottner P | 2002 | Soil Biology and Biochemistry2002，34，： | 1 |
| 19 | Temperature respon ses of net nitrogen nfinera显示文摘 | Dalias P Anderson J M Bottner P | 2002 | Soil Biology and Biochemistry2002，34，5： | 1 |
| 20 | Temperature responses of carbon mineralization in conifer forest soils from different regional climates incubated under standard laboratory conditions显示文摘 | Anderson J M Bottner P | 2001 | Global Change Biology2001，6，： | 1 |
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