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| 1 | Relationships between use of statins and arterial stiffness in normotensive and hypertensive patients with coronary artery disease显示文摘 | WANG Zhi-guang CHEN Bing-wei L(U) Na-qiang CHENG Yan-mei DANG Ai-min | 2013 | Chinese Medical Journal2013，，16： | 10 |
| 2 | Shikonin attenuates hyperhomocysteinemia-induced CD4E^+T cell inflammatory activation and atherosclerosis in ApoE^−/− mice by metabolic suppression显示文摘T cell metabolic activation plays a crucial role in inflammation of atherosclerosis.Shikonin(SKN),a natural naphthoquinone with anti-inflammatory activity,has shown to exert cardioprotective effects,but the effect of SKN on atherosclerosis is unclear.In addition,SKN was found to inhibit glycolysis via targeting pyruvate kinase muscle isozyme 2(PKM2).In the present study,we investigated the effects of SKN on hyperhomocysteinemia(HHcy)-accelerated atherosclerosis and T cell inflammatory activation in ApoE^−/− mice and the metabolic mechanisms in this process.Drinking water supplemented with Hcy(1.8 g/L)was administered to ApoE^−/− mice for 2 weeks and the mice were injected with SKN(1.2 mg/kg,i.p.)or vehicle every 3 days.We showed that SKN treatment markedly attenuated HHcy-accelerated atherosclerosis in ApoE^−/− mice and significantly decreased inflammatory activated CD4^+T cells and proinflammatory macrophages in plaques.In splenic CD4^+T cells isolated from HHcy-ApoE^−/− mice,SKN treatment significantly inhibited HHcy-stimulated PKM2 activity,interferon-γsecretion and the capacity of these T cells to promote macrophage proinflammatory polarization.SKN treatment significantly inhibited HHcy-stimulated CD4^+T cell glycolysis and oxidative phosphorylation.Metabolic profiling analysis of CD4^+T cells revealed that Hcy administration significantly increased various glucose metabolites as well as lipids and acetyl-CoA carboxylase 1,which were reversed by SKN treatment.In conclusion,our results suggest that SKN is effective to ameliorate atherosclerosis in HHcy-ApoE^−/− mice and this is at least partly associated with the inhibition of SKN on CD4^+T cell inflammatory activation via PKM2-dependent metabolic suppression. | Si-lin Lü Guo-hui Dang Jia-cheng Deng Hui-ying Liu Bo Liu Juan Yang Xiao-long Ma Yu-tong Miao Chang-tao Jiang Qing-bo Xu Xian Wang Juan Feng | 2020 | Acta Pharmacologica Sinica2020，41，1： | 4 |
| 3 | The effect of ganglioside on oxidation-induced permeability changes in lens and in epithelial cells of lens and retina显示文摘 | Bucolo C Lin LR Dang L | 1994 | Exp Eye Res1994，58，6： | 1 |
| 4 | The 800-nm diode laser irra- diation induces skin collagen synthesis by stimulating TGF- /Smad signaling pathway 显示文摘 | Dang Y Liu B Liu L | 2011 | Lasers Med Sci2011，26，6： | 1 |
| 5 | Konjac glucomannan as a carrier material for time: Temperature Integrator显示文摘 | Wang J Dang L Li Y | 2010 | Food Science and Technology2010，16，2： | 1 |
| 6 | Fast extraction, amplification and analysis of genes from human blood 显示文摘 | Zhang L Dang F Kaji N | 2006 | J Chromatogr A2006，1106，12： | 1 |
| 7 | Tubular atrophy and interstitial fibrosis after renal transplantation is dependent on galectin-3显示文摘 | Dang Z Mackinnon A Marson L P | | 0，，： | 1 |
| 8 | Plant pathogens and integrated defence responses to infection显示文摘 | Dang J L Jones J D G2 | | 0，，6839： | 1 |
| 9 | Improving arc joining of A1 to steel and A1 to stainless steel显示文摘 | Dong H G Yang L Q Dang C | 2012 | Materials Science and Engi- neering: A2012，534，： | 1 |
| 10 | Synthesis of nanocrystalline Ti O2with high photoactivity and large specific surface area by sol-gel method显示文摘 | Mao L Li Q Dang H | 2005 | Materials research bulletin2005，40，2： | 1 |
| 11 | Physicochemical properties of native and partially gelatinized high-amylose jackfruit (Artocarpus heterophyllus Lain)seed starch显示文摘 | Tran P L Dang H D N Do V H | 2015 | Lebensmittel- Wissenschaft und-Technologie2015，62，2： | 1 |
| 12 | Delay effect in models of population growth显示文摘 | Dang V G Yongwimon L Thomas I S | 2005 | J Math Appl2005，305，： | 1 |
| 13 | A review of current treatment for lumbar disc herniation in children and adolescents显示文摘 | Dang L Liu Z | 2010 | Eur Spine2010，19，2： | 1 |
| 14 | High glucose-induced human umbilical vein endothelial cell hyperpermeability is dependent on protein kinase C activation and independent of the Ca2 +-nitric oxide signalling pathway显示文摘 | DANG L SEALE JP Qu x | 2005 | Clln Exp Pharmacol Physiol2005，32，9： | 1 |
| 15 | Plant disease resistance protein signaling: NBS -LRR protein and their partners 显示文摘 | Belkhadir Y Subramaniam R Dang! J L | 2004 | Current Opinion in Plant Biology2004，7，： | 1 |
| 16 | Bioluminescent monitoring of islet graft survival after transplantation显示文摘 | Lu Y Dang H Middleton B Zhang Z Washburn L Campbell-Thompson M | | 0，，： | 1 |
| 17 | Removal of arsenic from simulated groundwater by adsorption using iron-modified rice husk carbon显示文摘 | Dang S V Kawasaki J Abella L C | 2009 | Journal of Water and Environment Technology2009，7，2： | 1 |
| 18 | Comparison between bipolar hemiarthro- plasty and total hip arthroplasty for unstable intertrochanterie frac- tures in elderly osteoporotic patients 显示文摘 | Fan L Dang X Wang K | 2012 | PLoS One2012，7，39： | 1 |
| 19 | Clinical analysis of concomitant valve replacement and bipolar radiofrequency ablation in 191 patients 显示文摘 | Dang L Fu B Teng X | 2013 | J Thorac Cardiovasc Surg2013，145，4： | 1 |
| 20 | Intensive care unit nurse staffing and the risk for complications after abdomi hal aortic surgery显示文摘 | Pronovost P J Dang D Dorman T et a l | 2001 | Eff Clin Pract2001，4，5： | 1 |
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