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| 1 | Environmental responsibilities of livestock feeding using trace mineral supplements显示文摘Trace elements are essential dietary components for livestock species. However, they also exhibit a strong toxic potential. Therefore, their fluxes through the animal organism are tightly regulated by a complex molecular machinery that controls the rate of absorption from the gut lumen as well as the amount of excretion via faeces, urine and products(e.g., milk) in order to maintain an internal equilibrium. When supplemented in doses above the gross requirement trace elements accumulate in urine and faeces and, hence, manure. Thereby, trace element emissions represent a potential threat to the environment. This fact is of particular importance in regard to the widely distributed feeding practice of pharmacological zinc and copper doses for the purpose of performance enhancement. Adverse environmental effects have been described, like impairment of plant production, accumulation in edible animal products and the water supply chain as well as the correlation between increased trace element loads and antimicrobial resistance. In the light of discussions about reducing the allowed upper limits for trace element loads in feed and manure from livestock production in the European Union excessive dosing needs to be critically reconsidered. Moreover, the precision in trace element feeding has to be increased in order to avoid unnecessary supplementation and, thereby, heavy metal emissions from livestock production. | Daniel Brugger Wilhelm M. Windisch | 2015 | Animal Nutrition2015，，3： | 7 |
| 2 | Strategies and challenges to increase the precision in feeding zinc to monogastric livestock显示文摘Practical diets for monogastric livestock must be supplemented with zinc(Zn) due to their high contents of antagonistic substances like phytates. Current feeding recommendations include quite generous safety margins because of uncertainties regarding the gross Zn requirements under varying rearing conditions.Furthermore, the use of pharmacological Zn doses to stabilise animal performance and wellbeing is widespread. Taken together, modern diets for pigs and poultry contain considerably more Zn than necessary to meet animal requirements, which is associated with concerns related to the environment as well as animal and consumer safety. Therefore, European authorities most recently reduced the allowed upper limits for Zn in complete feed. To maintain animal productivity and wellbeing while reducing the Zn load in complete feed, all measures that stabilize feed Zn bioavailability must be applied. Most importantly, reliable information on the gross Zn requirement under practical conditions must be provided, considering the bioavailability of native or supplemented feed Zn, antagonisms with dietary factors as well as the physiological status of the animal. | Daniel Brugger Wilhelm M.Windisch | 2017 | Animal Nutrition2017，，2： | 2 |
| 3 | Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model显示文摘Early weaning induces intestinal injury,leading to a series of long-term symptoms such as inflammation,malabsorption and diarrhea.In this study,we hypothesized that microbes and theirmetabolitesmodulate the host's inflammatory response to early weaning stress in a goatmodel.A total of 18 female Tibetan goat kids(n?9)wereweaned fromtheirmothers at 28 d(D28)and 60 d(D60)postpartum.D60 and D28 groupswere fed the same solid diet ad libitum fromweaning to 75 d of age.The colonic epithelium was subject to RNAsequencing,the caecal digesta metabolomics were assessed by liquid chromatographyetandem mass spectrometry(LC-MS/MS),and the caecal microbiota composition was analysed by 16S ribosomal RNA gene sequencing.We foundthatearlyweaningsubstantially increased the colonic pro-apoptotic gene expressionof B-cell lymphoma associated X(Bax),caspase-9,and caspase-3,and decreased the expression of zonula occludens-1(ZO-1)and claudin-1(P<0.01).In addition,a significant Bacteroides acidifaciens enrichmentwas observed in the hindgut of early-weaned goats(P<0.01),which negatively correlated with lysophosphatidylcholine products.Similarly,the chemokine signaling,IL-17 signaling,and peroxisome proliferatorsactivated receptor(PPAR)signaling pathways were upregulated in the colonic mucosa of the early-weaned goats.By applying caecal microbiota transplantation from goats to defaunated C57/6J mice,we confirmed that caecalmicrobiota of D28 goat kids increased the relative abundance of B.acidifaciens and significantly upregulated the genes of Bax,G proteinecoupled receptor(GPR)109A,GPR 43,fatty acid binding protein 6,nuclear receptor subfamily 1 group H member 3,angiotensin converting enzyme 2,and IL-6 expression(P<0.05),and decreased ZO-1,and claudin-1 protein expression in the mice jejunum and colon(P<0.001).These results proposed that the hindgut microbiota andmetabolites mediate the barrier functionweakening duringearlyweaning,and the relative abundance of B.acidifacienswas negatively correlatedwiththe hindgut barrier gene expression.This studydemonstrateshowweaningstress canaffectkeyhostemicrobe interaction regulators in the hindgut,in a lysophosphatidylcholine dependent and independent manner.Furthermore,based on our mice data,these results are transferable to other mammal species. | Ke Zhang Yangbin Xu Yuxin Yang Mengmeng Guo Ting Zhang Bo Zong Shuhong Huang Langda Suo Baohua Ma Xiaolong Wang Yujiang Wu Daniel Brugger Yulin Chen | 2022 | Animal Nutrition2022，，3： | 2 |
| 4 | 废弃筒仓变身攀岩健身房——蒙特利尔Allez-Up攀岩健身房显示文摘Allez-Up攀岩健身房是蒙特利尔西南行政区改建项目中的重点项目,该项目位于拉欣运河一侧,原址是老雷德帕思糖厂的筒仓,但如今已被改造成一个室内攀岩健身房,成为运河周边著名的旅游景点和娱乐休闲场所。将废弃的仓库改建成一个攀岩健身房是将蒙特利尔工业时代遗留的建筑的潜能最大化利用的一种独特方法。 | Daniel Smith Karine Renaud Anik Malderis tienne Penault Cindy Neveu Mélanie Quesnel Stéphan Vigeant Stéphane Brugger | 2014 | 设计家2014，，6： | 1 |
| 5 | 单胃动物锌代谢及其对营养需要量和饲料锌生物利用率估算的影响(英文)显示文摘矿物质营养研究的主要目标是为猪饲养者提供饲料锌利用率和总锌需要量信息,这些需要量信息受到饲养条件的影响.这只能通过应用精确实验模型来阐明锌代谢的基本原理.本综述总结了单胃动物体内锌稳态的最重要方面,包括锌的获取和排泄的分子机理,尤其强调骨骼以及外分泌胰腺在这种稳态调节中的作用.最后,文章讨论了上述生理学原理对试验设计产生的影响,旨在解决锌需要量和生物利用率的问题. | Daniel BRUGGER Wilhelm M.WINDISCH | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，8： | 0 |
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