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| 1 | Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery显示文摘Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration(GBR)and are often made of resorbable collagen or non-resorbable materials such as PTFE.While collagen membranes do not provide sufficient mechanical protection of the covered bone defect,titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery.Thus,biodegradable GBR membranes made of pure magnesium might be an alternative.In this study a biodegradable pure magnesium(99.95%)membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective.After implantation,the magnesium membrane separates the regenerating bone from the overlying,faster proliferating soft tissue.During the initial healing period,the membrane maintained a barrier function and space provision,whilst retaining the positioning of the bone graft material within the defect space.As the magnesium metal corroded,it formed a salty corrosion layer and local gas cavities,both of which extended the functional lifespan of the membrane barrier capabilities.During the resorption of the magnesium metal and magnesium salts,it was observed that the membrane became surrounded and then replaced by new bone.After the membrane had completely resorbed,only healthy tissue remained.The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane.Overall,the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment. | Patrick Rider Zeljka Peric Kacarevic Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Emely Bortel Bernhard Hesse Frank Witte | 2022 | Bioactive Materials2022，7，8： | 7 |
| 2 | Differential regulation of EphA2 in normal and malignant cells 显示文摘 | WALKER DANIELS J HESS A R HENDRIX M J | 2003 | Am J Pathol2003，162，4： | 1 |
| 3 | 2-aminoethyl Dihydrogen Phosphate as a Modulator of Proliferative and Apoptotic Effects in Breast Cancer Cell Lines显示文摘Background: Breast cancer is a type of cancer that affects more women throughout the world, in developing anddeveloped countries. 2-AEH2P is a phospholipid analog of cellular membrane, which makes it different from existing molecules fortheir absorption, stability and display anti-inflammatory, anti-proliferative and pro-apoptotic properties. Methods: MCF-7 humanbreast adenocarcinoma cells were treated with 2-AEH2P. The viability and adhesion cells were evaluated by MTT assay. Cell cyclephases, apoptosis, markers and mitochondrial potential were assessed by flow cytometry. Morphological ultrastructural analyzeswere performed by laser confocal microscopy. Results: MCF-7 Tumor cells acquired round shapes, lost cytoplasmic expansions,formed clusters in suspension and decreased significantly viability. There were changes in the morphology, membrane fragmentationand loss of cytoplasmic projection. The obtained concentrations for IC50% were 37.2;25.8;1.8 mM for periods of 24, 48 and 72 h,respectively. Changes in the distribution of cell population phases of the cell cycle showed an increase in fragmented DNA and anincrease in the G2/M phase. The expression β-gal showed proliferative reduction induced by 2-AEH2P. Laser confocal microscopyshowed changes in the mitochondrial membrane and alteration in distribution. Proliferative index of MCF-7 tumor cells treated with2-AEH2P decreased significantly when compared to fibroblast normal cells. The compound 2-AEH2P is a phospholipid withantiproliferative potential and apoptosis modulator. | Manuela Garcia Laveli da Silva Laertty Garcia de Sousa Cabral Monique Gonçalves Alves Thais deOliveira Conceição Henrique Hesse Rosa Andrea Nogueira Laiso Daniel da Conceição Rabelo Durvanei Augusto Maria | 2021 | Journal of Pharmacy and Pharmacology2021，9，3： | 1 |
| 4 | Patient Outcome Following Two Different Stress Imaging Approaches: A Prospective Randomized Comparison显示文摘 | Thomas R. Porter Lynette M. Smith Juefei Wu Deepak Thomas John T. Haas Daniel H. Mathers Eric Williams Joan Olson Kevin Nalty Roberta Hess Stacey Therrien Feng Xie | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 5 | Development of an ultra-performance liquid chromatography–mass spectrometry method for the detection of lipophilic marine toxins显示文摘 | Elie Fux Daniel McMillan Ronel Bire Philipp Hess | 2007 | Journal of Chromatography A2007，，1： | 1 |
| 6 | A single probe spatial averaging technique for guided waves and its applica-tion to surface wave rail inspection显示文摘 | Daniel Hesse Peter Cawley | 2007 | IEEE Transactions on Ultrasonics2007，，11： | 1 |
| 7 | Directed Proteomics Identifies a Plant - Specific Protein Rapidly Phospho- rylated in Response to Bacterial and Fungal Elicitors 显示文摘 | Scott C Peck Thomas S Nuhse Daniel Hess | 2001 | The Plant Cell2001，13，： | 1 |
| 8 | Part 8: Adult Advanced Cardiovascular Life Support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care显示文摘 | Robert W. Neumar Charles W. Otto Mark S. Link Steven L. Kronick Michael Shuster Clifton W. Callaway Peter J. Kudenchuk Joseph P. Ornato Bryan McNally Scott M. Silvers Rod S. Passman Roger D. White Erik P. Hess Wanchun Tang Daniel Davis Elizabeth Sinz Laur | 2010 | Circulation ( Suppl )2010，，18： | 1 |
| 9 | High prevalence of glaucoma in patients with sleep apnea syndrome显示文摘 | Daniel S Mojon Christian W Hess David Goldblum Johannes Fleischhauer Fritz Koerner Claudio Bassetti Johannes Mathis | 1999 | Ophthalmology1999，，5： | 1 |
| 10 | Extent of Aortic Coverage and Incidence of Spinal Cord Ischemia After Thoracic Endovascular Aneurysm Repair显示文摘 | Robert J. Feezor Tomas D. Martin Philip J. Hess Michael J. Daniels Thomas M. Beaver Charles T. Klodell W. Anthony Lee | 2008 | The Annals of Thoracic Surgery2008，，6： | 1 |
| 11 | Late Outcomes of a Single-Center Experience of 400 Consecutive Thoracic Endovascular Aortic Repairs显示文摘 | W. Anthony Lee Michael J. Daniels Thomas M. Beaver Charles T. Klodell Dan E. Raghinaru Philip J. Hess | 2011 | Circulation2011，，25： | 1 |
| 12 | Development of an ultra-performance liquid chromatography–mass spectrometry method for the detection of lipophilic marine toxins显示文摘 | Elie Fux Daniel McMillan Ronel Bire Philipp Hess | 2007 | Journal of Chromatography A2007，，1： | 1 |
| 13 | Biodegradable magnesium fixation screw for barrier membranes used in guided bone regeneration显示文摘An ideal fixation system for guided bone(GBR)regeneration in oral surgery must fulfil several criteria that includes the provision of adequate mechanical fixation,complete resorption when no longer needed,complete replacement by bone,as well as be biocompatible and have a good clinical manageability.For the first time,a biodegradable magnesium fixation screw made of the magnesium alloy WZM211 with a MgF2 coating has been designed and tested to fulfill these criteria.Adequate mechanical fixation was shown for the magnesium fixation screw in several benchtop tests that directly compared the magnesium fixation screw with an equivalent polymeric resorbable device.Results demonstrated slightly superior mechanical properties of the magnesium device in comparison to the polymeric device even after 4 weeks of degradation.Biocompatibility of the magnesium fixation screw was demonstrated in several in vitro and in vivo tests.Degradation of the magnesium screw was investigated in in vitro and in vivo tests,where it was found that the screw is resorbed slowly and completely after 52 weeks,providing adequate fixation in the early critical healing phase.Overall,the magnesium fixation screw demonstrates all of the key properties required for an ideal fixation screw of membranes used in guided bone regeneration(GBR)surgeries. | Zeljka Peric Kacarevic Patrick Rider Akiva Elad Drazen Tadic Daniel Rothamel Gerrit Sauer Fabien Bornert Peter Windisch David Botond Hangyasi Balint Molnar Till Kammerer Bernhard Hesse Emely Bortel Marco Bartosch Frank Witte | 2022 | Bioactive Materials2022，7，8： | 0 |
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