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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | A carbohyz drate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody 显示文摘 | Skehel JJ Stevens DJ Daniels RS | 1984 | Proc Natl Acad Sci USA1984，81，6： | 1 |
| 3 | Prospective, randomized, endoscopic-blinded trial comparing precolonoscopy bowel cleansing methods显示文摘 | Cohen SM Wexner SD Binderow SR Nogueras JJ Daniel N Ehrenpreis ED Jensen J Bonner GF Ruderman WB | 1994 | Dis Colon Rectum1994，37，7： | 1 |
| 4 | Desensitization of vascular response in vivo: contribution of genetic variation in the α2B-adrenergic receptor subtype显示文摘 | Mordechai Muszkat Daniel Kurnik Gbenga G Sofowora Joseph Solus Hong-Guang Xie Paul A Harris Scott M Williams Alastair JJ Wood C Michael Stein | 2010 | Journal of Hypertension2010，，2： | 1 |
| 5 | The validity of emergency department triage blood pressure measurements 显示文摘 | Clenki JJ DeLuca LA Daniel N | 2004 | Acad Emerg Med2004，11，： | 1 |
| 6 | Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors显示文摘 | Kohonen MR Daniel JJ Riele H | 2002 | Cancer Res2002，62，7： | 1 |
| 7 | Global analysis of nitrogen and phosphorus limitation of primary producers in freshwater, marine and terrestrial ecosystems 显示文摘 | Elser JJ Bracken ME Cleland EE Gruner Daniel S Harpole WS Hillebrand H Ngai JT Seabloom EW Shurin JB Smith JE | 2007 | Ecol Lett2007，10，12： | 1 |
| 8 | Eye on diabetes: a multidisciplinary patient education intervention显示文摘 | Wagner H Pizzimenti JJ Daniel K | 2008 | Diabetes Educ2008，34，1： | 1 |
| 9 | Modulation of cardiac ischemia-sensitive afferent neuron sig-naling by preemptive C2 spinal cord stimulation:effect on sub-stance P release from rat spinal cord显示文摘 | Ding X Ardell JL Hua F McAuley RJ Sutherly K Daniel JJ | 2008 | Am J Physiol Regul Inte-gr Comp Physiol2008，294，1： | 1 |
| 10 | Preliminary NINDS neuropathologie criteria for Steele - Richardson - Olszewski syndrome ( progressive supranuclear palsy) 显示文摘 | Hauw JJ Daniel SE Diekson D | 1994 | Neurology1994，44，： | 1 |
| 11 | Low microsatellite instability is associated with poor prognosis in stage C colon cancer显示文摘 | Kohonen-Corish MR Daniel JJ Chan C | 2005 | J Clin Oncol2005，23，： | 1 |
| 12 | Service-learning in nursing education:Its impact on leadership and social justice显示文摘 | Groh CJ Stallwood LG Daniels JJ | 2011 | Nurs Educ Perspect2011，32，6： | 1 |
| 13 | Low microsate llite instability is associated with poor prognosis in stage C colon cancer 显示文摘 | Kohonen-Cofish MR Daniel JJ Chan C ct al | 2002 | J Clin Oncol2002，20，10： | 1 |
| 14 | Lipoproteins,cholesterol homeostasis and cardiac health显示文摘 | Daniels TF Killinger KM Michal JJ | 2009 | Int J Biol Sci2009，5，5： | 1 |
| 15 | Service -learning in nursing ed- ucation:Its impact on leadership and social justice显示文摘 | Groh C J Stallwood LG Daniels JJ | 2011 | Nurs Educ Perspect2011，32，6： | 1 |
| 16 | Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways 显示文摘 | Yon JH Daniel JJ Carter LB | 2005 | Neuroscience2005，135，3： | 1 |
| 17 | BRCA1,BRCA2 and Rad51 operate in a common DNA damage response pathway显示文摘 | Daniel Silver Sharon Canter | 1999 | Cancer Res (suppl)1999，59，： | 1 |
| 18 | Three-dimenslonal characterization of textile composites显示文摘 | DANIEL IM LUO JJ SCHUBEL PM | 2008 | Composites:Part B2008，39，1： | 1 |
| 19 | Low microsatellite instability is associated with poor prognosis in stage C colon cancer 显示文摘 | Kohonen-Corish MR Daniel JJ Chan C | 2005 | J Clin Oncol2005，23，4： | 1 |
| 20 | The role of the MAPK superfamily in beta-amyloid toxicity显示文摘 | Daniels WM Hendricks J Salie R Taljaard JJ | 2001 | Metab Brain Dis2001，16，34： | 1 |
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