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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Preparation of porcine carotid arteries for vascular tissue engineering applications显示文摘 | McFetridge PS Daniel JW Bodamyali T | | 0，，02： | 1 |
| 3 | Inflammation, in-sulin, and endothelial function in overweight children and adolescents: The role of exercise显示文摘 | Aaron SK Rachel JW Daniel RK | 2004 | J Pediatr2004，145，6： | 1 |
| 4 | Preparation of porcine carotid arteries for vascular tissue eagincering applications 显示文摘 | Mcfetridgc PS Daniel JW Bodamyali T | 2004 | J Biomed Mater Res A2004，70，2： | 1 |
| 5 | Hemorrhagic cystisis after bone marrow transplantation:risk factors and complications显示文摘 | Susan FS Roberj JH Daniel JW | 1993 | Transplantation1993，56，： | 1 |
| 6 | Preparation of porcine carotid arteries for vascular tissue engineering applications显示文摘 | McFetridge PS Daniel JW Bodamyali T | 2004 | J Biomed Mater Res2004，70，2： | 1 |
| 7 | Foot fellow、review显示文摘 | Daniels TH Smith JW | 1993 | Foot Ankle1993，13，： | 1 |
| 8 | Talar neck fractures显示文摘 | Daniels TR Smith JW | 1993 | Foot Ankle Int1993，14，4： | 1 |
| 9 | Diced cartilage grafts in rhinoplasty surgery 显示文摘 | Daniel RK Calvert JW | 2004 | Plast Reconstr Surg2004，113，7： | 1 |
| 10 | Investigation of coloncancers for human pap illomavirus genomic sequences by polymerase chain reaction显示文摘 | Shah KV Daniel RW Simons JW | 1992 | J Surg Oncol1992，51，1： | 1 |
| 11 | The pure culture of Physarum Polycephalum on a partially defined soluble medium显示文摘 | DANIEL JW | 1961 | Journal of General Microbiolo- gy1961，25，： | 1 |
| 12 | The emerging role of dairy protein and bioactive peptide in nutrition and health显示文摘 | Richard J F Brain AM Daniel JW | | 0，，04： | 1 |
| 13 | Multiple second messenger pathways of alphaadrenergic receptor subtypes expressed in eukaryotic cells显示文摘 | Cotecchia S Kobilka BK Daniel KW Nolan RD Lapetina EY Caron MG Lefkowitz ILl Regan JW | 1990 | J Biol Chem1990，265，： | 1 |
| 14 | Use of assistive tech- nology with young children with severe and profound disabili- ties 显示文摘 | Daniels LE Sparling JW Reilly M | 1995 | Infant-Toddler Intervention1995，5，： | 1 |
| 15 | Diced cartilage grafts in rhinoplasty sur- gery显示文摘 | Daniel RK Calvert JW | 2004 | Plast Reconstr Surg2004，113，7： | 1 |
| 16 | Sequential gene promoter interactions of C/EBP beta, C/EBP alpha, and PPAR gamma during adipogenesis 显示文摘 | Tang QQ Zhang JW Daniel LM | 2004 | Biochem Biophys Res Commun2004，319，1： | 1 |
| 17 | Effects of variation in protein and carbohydrate intake on body mass and composition during energy restriction: a meta- regression 1 显示文摘 | Krieger JW Sitern HS Daniels M] | 2006 | Am J Clin Nutr2006，83，2： | 1 |
| 18 | Effectiveness of methylprednisolone in the acute phase of spinal cord injuries:a systematic review of randomized controlled trials显示文摘 | Botelho RV Daniel JW Boulosa JL | 2009 | Rev Assoc Med Bras2009，55，6： | 1 |
| 19 | Ras protein famesyltrans- ferase:a strategic target for anticancer显示文摘 | Rowinsky K Jolene JW Daniel D | 1999 | J Clin Oncol1999，17，11： | 1 |
| 20 | Metabolic syn- drome and risk of incident cardiovascular events and death显示文摘 | Apoor SG Brandi JW Daniel EH | 2007 | J Am Call Cardiol2007，49，4： | 1 |
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