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| 1 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 2 | A framework infrageneric classification of Carex (Cyperaceae) and its organizing principles显示文摘Phylogenetic studies of Carex L.(Cyperaceae)have consistently demonstrated that most subgenera and sections are para-or polyphyletic.Yet,taxonomists continue to use subgenera and sections in Carex classification.Why?The Global Carex Group(GCG)here takes the position that the historical and continued use of subgenera and sections serves to(i)organize our understanding of lineages in Carex,(ii)create an identification mechanism to break the~2000 species of Carex into manageable groups and stimulate its study,and(iii)provide a framework to recognize morphologically diagnosable lineages within Carex.Unfortunately,the current understanding of phylogenetic relationships in Carex is not yet sufficient for a global reclassification of the genus within a Linnean infrageneric(sectional)framework.Rather than leaving Carex classification in its current state,which is misleading and confusing,we here take the intermediate steps of implementing the recently revised subgeneric classification and using a combination of informally named clades and formally named sections to reflect the current state of our knowledge.This hybrid classification framework is presented in an order corresponding to a linear arrangement of the clades on a ladderized phylogeny,largely based on the recent phylogenies published by the GCG.It organizes Carex into six subgenera,which are,in turn,subdivided into 62 formally named Linnean sections plus 49 informal groups.This framework will serve as a roadmap for research on Carex phylogeny,enabling further development of a complete reclassification by presenting relevant morphological and geographical information on clades where possible and standardizing the use of formal sectional names. | Eric H.Roalson Pedro Jiménez-Mejías Andrew L.Hipp Carmen Benítez-Benítez Leo P.Bruederle Kyong-Sook Chung Marcial Escudero Bruce A.Ford Kerry Ford Sebastian Gebauer Berit Gehrke Marlene Hahn Muhammad Qasim Hayat Mathias H.Hoffmann Xiao-Feng Jin Sangtae Kim Isabel Larridon Étienne Léveillé-Bourret Yi-Fei Lu Modesto Luceño Enrique Maguilla Jose IgnacioMárquez-Corro Santiago Martín-Bravo Tomomi Masaki Mónica Míguez Robert F.C.Naczi Anton A.Reznicek Daniel Spalink Julian R.Starr Uzma Tamara Villaverde Marcia J.Waterway Karen L.Wilson and Shu-Ren Zhang | 2021 | Journal of Systematics and Evolution2021，59，4： | 3 |
| 3 | Second-generation direct-acting-antiviral hepatitis C virus treatment: Efficacy, safety, and predictors of SVR12显示文摘AIM To gather data on the antiviral efficacy and safety of second generation direct acting antiviral(DAA) treatment with respect to sustained virological response(SVR) 12 wk after conclusion of treatment, and to determine predictors of SVR12 in this setting.METHODS Two hundred and sixty patients treated with SOF combination partners PR(n = 51), R(n = 10), SMV(n = 30), DCV(n = 81), LDV(n = 73), or 3D(n = 15).144/260 were pre-treated, 89/260 had liver cirrhosis, 56/260 had portal hypertension with platelets < 100/nL, 25/260 had a MELD score ≥ 10 and 17/260 were postliver transplantation patients. 194/260 had HCV GT1, 44/260 HCV GT3.RESULTS Two hundred and forty/256(93.7%) patients achieved SVR12(m ITT); 4/260 were lost to follow-up. SVR12 rates for subgroups were: 92% for SOF/DCV, 93% for each SOF/SMV, SOF/PR, 94% for SOF/LDV, 100% for 3D, 94% for pretreated, 87% for liver cirrhosis, 82% for patients with platelets < 100/n L, 88% post-liver transplantation, 95% for GT1 a, 93% for GT1 b, 90% for GT3, 100% for GT2, 4, and 6. 12 patients suffered from relapse, 6 prematurely discontinued treatment, of which 4 died. Negative predictors of SVR12 were a platelet count < 100/nL, MELD score ≥ 10(P < 0.0001), liver cirrhosis(P = 0.005) at baseline. In Interferonfree treatment GT3 had significantly lower SVR rates than GT1(P = 0.016). Side effects were mild. CONCLUSION Excellent SVR12 rates and the favorable side-effect profile of DAA-combination therapy can be well translated into 'real-world'. Patients with advanced liver disease, signs of portal hypertension, especially with platelets < 100/n L and patients with GT3 are in special need for further research efforts to overcome comparatively higher rates of virological failure. | Christoph R Werner Julia M Schwarz Daniel P Egetemeyr Robert Beck Nisar P Malek Ulrich M Lauer Christoph P Berg | 2016 | World Journal of Gastroenterology2016，22，35： | 2 |
| 4 | Vacuole Integrity Maintained by DUF300 Proteins Is Required for Brassinosteroid Signaling Regulation显示文摘Brassinosteroid (BR ) 荷尔蒙发信号在植物生长和开发期间控制多重进程并且和象联系 BRI1 的受体 KINASE1 (BAK1 ) 那样的合作受体通过受体 kinase BRASSINOSTEROID INSENSITIVE1 (BRI1 ) 在血浆膜被开始。BRI1 丰富被 endosomal 再循环并且 vacuolar 指向调整,但是在 BR 受体动力学和 BR 回答的液泡相关的蛋白质的角色留下逃犯。这里,我们证明 BR 发信号的二 DUF300 包含域的 tonoplast 蛋白质, LAZARUS1 (LAZ1 ) 和 LAZ1 HOMOLOG1 (LAZ1H1 ) 的缺席,原因液泡形态学缺点,生长抑制,和组成的激活。有趣地, BAK1 的 tonoplast 累积实质地被增加并且显得有原因地在 laz1 laz1h1 植物连接了到提高的 BRI1 trafficking 和降级。因为无关的液泡异种展出了正常 BR 回答,我们的调查结果显示 DUF300 蛋白质在由维持要求平衡 subcellular BAK1 水池和 BR 受体分发的液泡正直发信号的 BR 的规定起不同作用。 | Qinsong Liu Thomas Vain Corrado Viotti Siamsa M, Doyle Danuse Tarkowska Ondrej Novak Cyril Zipfel Folke Sitbon Stephanie Robert Daniel Hofius | 2018 | Molecular Plant2018，11，4： | 2 |
| 5 | Vorapaxar for secondary prevention of thrombotic events for patients with previous myocardial infarction: a prespecified subgroup analysis of the TRA 2°P-TIMI 50 trial显示文摘 | Benjamin M Scirica Marc P Bonaca Eugene Braunwald Gaetano M De Ferrari Daniel Isaza Basil S Lewis Felix Mehrhof Piera A Merlini Sabina A Murphy Marc S Sabatine Michal Tendera Frans Van de Werf Robert Wilcox David A Morrow | 2012 | The Lancet . 2012 (9850)2012，，9850： | 1 |
| 6 | 显示文摘 | Robert J Dombrowski Daniel R Hyduke Christian M Lastoskie | 2000 | Langmuir2000，16，： | 1 |
| 7 | Water-selective and multifunctional aquaporins from Lotus japonious nodules显示文摘 | James F Guenther Daniel M Roberts | 2000 | Planta2000，210，： | 1 |
| 8 | Early renal ischemia with or without reperfusion activates NF - KB and increases TNF - bioactivity in the kindney显示文摘 | KIRSTAN K D DANIEL R M ROBERT S | 2000 | Urology2000，163，4： | 1 |
| 9 | Pore size analysis of activated carbons from argon and nitrogen porosimetry using density functional theory显示文摘 | Robert J Dombrowski Daniel R Hyduke Christian M Lastoskie | 2000 | Langmuir2000，16，11： | 1 |
| 10 | Biocontrol agents applied individually and in combination for suppression of soilborne diseases of cucumber显示文摘 | DANIEL P ROBERT SCOTT M LOHRKE | 2005 | Crop Protectiong2005，24，2： | 1 |
| 11 | The synthesis of ketol- ide antibiotic ABT - 773 (cethromycin) 显示文摘 | Daniel J P M Robert L Michael R | 2004 | Tetrahedron2004，60，10： | 1 |
| 12 | High-temperature wells with lost-circulation demands and reverse-circulation techniques using foames-cement systems: Two case histories显示文摘 | Robert M Daniel L B Shawn R | | SPE 845630，200，： | 1 |
| 13 | Lymphoepithelial cysts of the pancreas:a management dilemma显示文摘Pancreatic lymphoepithelial cysts(LECs) are rare,benign lesions that are typically unexpected post-operative pathological findings. We aimed to review clinical, radiological and pathological features of LECs that may allow their preoperative diagnosis. Histopathology databases of two large pancreatic units were searched to identify LECs and notes reviewed to determine patient demographic details, mode of presentation, investigations, treatment and outcome. Five male and one female patients were identified. Their median age was 60 years. Lesions were identified on computed tomography performed for abdominal pain in two patients, and were incidentally observed in four patients. Five LECs were located in the tail and one in the body of the pancreas, with a median cyst size of 5 cm. Obtaining cyst fluid was difficult and a largely acellular aspirate was yielded. The pre-operative diagnosis was mucinous cystic neoplasm in all patients. This series of patients were treated distal pancreatectomy and splenectomy. A retrospective review of radiological examinations suggested that LECs have a relatively low signal on T2 imaging and a high signal intensity on T1 weighted images. LECs appear more common in elderly males, and are typically incidental, large, unilocular cysts. Close attention to signal intensity on MRI may allow preoperative diagnosis of these lesions. | Julie Martin Keith J Roberts Maria Sheridan Gavin A Falk Daniel Joyce R Matthew Walsh Andrew M Smith Gareth Morris-Stiff | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，5： | 1 |
| 14 | Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual显示文摘 | S.Eva Singletary Craig Allred Pandora Ashley Lawrence W Bassett Donald Berry Kirby I Bland Patrick I Borgen Gary M Clark Stephen B Edge Daniel F Hayes Lorie L Hughes Robert V.P Hutter Monica Morrow David L Page Abram Recht Richard L Theriault Ann Thor Don | 2003 | Surgical Clinics of North America2003，，4： | 1 |
| 15 | The effect of rapid thermal processing (RTP) on TiN coatings deposited by PVD and the steel-turning performance of coated cemen- ted carbide 显示文摘 | Anthoy J Perry J N Steve J Bull Dmitri I P Peter C R Trevor F P Daniel E G James T John J V Robert E D Vladinmir R Alexey B M | 1999 | Surface and Coatings Technology1999，120，121： | 1 |
| 16 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 1 |
| 17 | Towards an integrated global framework to assess the impacts of land use and management change on soil carbon: current capability and future vision显示文摘 | Pete Smith Christian A. Davies Stephen Ogle Giuliana Zanchi Jessica Bellarby Neil Bird Robert M. Boddey Niall P. M c Namara David Powlson Annette Cowie Meine Noordwijk Sarah C. Davis Daniel DE B. Richter Len Kryzanowski Mark T. Wijk Judith Stuart Akira Ki | 2012 | Glob Change Biol2012，，7： | 1 |
| 18 | Supercomputer inves- tigation of a chaotic encryption algorithm 显示文摘 | DANIEL D W ROBERT A J M | 1991 | Cryptolo- gia1991，15，2： | 1 |
| 19 | Global and regional decreases in tropospheric oxidants from photochemical effects of aerosols显示文摘 | Martin R V Daniel J J Robert M Y | 2003 | Journal of Geophysical Research2003，108，3： | 1 |
| 20 | Failure mechanisms of magnesia alumina spinel abradable coatings under thermal cyclic loading显示文摘 | Svenja Ebert Robert Mücke Daniel Mack Robert Va?en Detlev St?ver Tanja Wobst Susanne Gebhard | 2013 | Journal of the European Ceramic Society2013，，： | 1 |
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