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| 1 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 2 | PPARγ in immunity and inflammation:cell types and diseases显示文摘 | Lajos SzO les Daniel Tiircesik Lfszl6 Nagy | 2007 | Biochimiea et Biophysica Aeta (BBA)-Molecular and Cell Biology of Lipids2007，1771，8： | 1 |
| 3 | Distribution of elastic fibres in the developing rabbit craniomandibular joint 显示文摘 | Nagy NB Daniel JC | 1991 | Arch Oral Biol1991，36，： | 1 |
| 4 | An inhibitory function of WW domain-containing host proteins in RNA virus replication显示文摘 | Jun Qin Daniel B Nagy P D | 2012 | Virology2012，426，： | 1 |
| 5 | Myocardial infarction with normal coronary arteries is common and associated with normal findings on cardiovascular magnetic resonance imaging: results from the S tockholm M yocardial I nfarction with N ormal C oronaries study显示文摘 | O. Collste P. S?rensson M. Frick S. Agewall M. Daniel L. Henareh C. Ekenb?ck L. Eurenius C. Guiron T. Jernberg C. Hofman‐Bang K. Malmqvist E. Nagy H. Arheden P. Tornvall | 2012 | J Intern Med2012，，2： | 1 |
| 6 | Ganirelix acetate use in normal- and poor-prognosis patients and the impact of estradiol patterns显示文摘 | Daniel B. Shapiro Dorothy Mitchell-Leef Melinda Carter Zsolt Peter Nagy | 2005 | Fertility and Sterility2005，，3： | 1 |
| 7 | Upregulation of the 5-Lipoxygenase Pathway in Human Aortic Valves Correlates With Severity of Stenosis and Leads to Leukotriene-Induced Effects on Valvular Myofibroblasts显示文摘 | Edit Nagy Daniel C. Andersson Kenneth Caidahl Maria J. Eriksson Per Eriksson Anders Franco-Cereceda G?ran K. Hansson Magnus B?ck | 2011 | Circulation2011，，12： | 1 |
| 8 | Effect of silver-nanoparticles generated in poly(vinyl alcohol)membranes on ethanol dehydration via pervaporation显示文摘Pervaporation is an important membrane separation method of chemical engineering.In this work,silver-nanoparticles-poly(vinyl alcohol)nanocomposite membranes(AgNPs-PVA)are produced for the sake of improving its potentials for pervaporation of ethanol–water mixture so that the usual opposite trend between membrane selectivity and permeation can be reduced.The nanocomposite membranes are fabricated from an aqueous solution of poly(vinyl alcohol)with silver nanoparticles via the in-situ generation technique in the absence of any reducing agent.Successful generation of the nano size silver is measured by the UV–vis spectrum showing a single peak at 419 nm due to the plasmonic effect of silver nanoparticles.Our nanocomposite AgNPs-PVA membranes are characterized using scanning electron microscope(SEM),Fourier-transform infrared(FT-IR)spectroscopy,X-ray diffraction and thermogravimetric analysis(TGA).The pervaporation tests of our new AgNPs-PVA membranes show good results since at a higher temperature and higher ethanol concentration in the feed,the prepared membranes are highly permeable for the water having stable selectivity values and therefore our membranes show better performance compared to that of the other PVA-based nanocomposite membranes. | Asmaa Selim Andras Jozsef Toth Daniel Fozer Eniko Haaz Nóra Valentínyi Tibor Nagy Orsolya Keri Lászlo Péter Bakos Imre Miklós Szilágyi Peter Mizsey | 2019 | Chinese Journal of Chemical Engineering2019，27，7： | 0 |
| 9 | Nano-Electronic Simulation Software (NESS): A Novel Open-Source TCAD Simulation Environment显示文摘This paper presents the latest status of the open source advanced TCAD simulator called Nano-Electronic Simulation Software(NESS)which is currently under development at the Device Modeling Group of the University of Glasgow.NESS is designed with the main aim to provide an open,flexible,and easy to use simulation environment where users are able not only to perform numerical simulations but also to develop and implement new simulation methods and models.Currently,NESS is organized into two main components:the structure generator and a collection of different numerical solvers;which are linked to supporting components such as an effective mass extractor and materials database.This paper gives a brief overview of each of the components by describing their main capabilities,structure,and theory behind each one of them.Moreover,to illustrate the capabilities of each component,here we have given examples considering various device structures,architectures,materials,etc.at multiple simulation conditions.We expect that NESS will prove to be a great tool for both conventional as well as exploratory device research programs and projects. | Cristina Medina-Bailon Tapas Dutta Fikru Adamu-Lema Ali Rezaei Daniel Nagy Vihar P.Georgiev Asen Asenov | 2020 | Journal of Microelectronic Manufacturing2020，3，4： | 0 |
| 10 | Long-term outcomes of the four-corner fusion of the wrist:A systematic review显示文摘BACKGROUND Four-corner fusion(4CF)is a motion sparing salvage procedure that is used to treat osteoarthritis secondary to advanced scapholunate collapse or longstanding scaphoid nonunion advanced collapse.Little is known about the long-term survivorship and outcomes of 4CF.AIM To report on clinical and functional long-term outcomes as well as conversion rates to total wrist fusion or arthroplasty.METHODS The systematic review protocol was registered in the international prospective register of systematic reviews(PROSPERO)and followed the PRISMA guidelines.Original articles were screened using four different databases.Studies with a minimum Level IV of evidence that reported on long-term outcome after 4CF with a minimum follow-up of 5 years were included.Quality assessment was performed using the Methodological Index for Non-Randomized Studies criteria.RESULTS A total of 11 studies including 436 wrists with a mean follow-up of 11±4 years(range:6-18 years)was included.Quality assessment according to Methodological Index for Non-Randomized Studies criteria tool averaged 69%±11%(range:50%-87%).Fusion rate could be extracted from 9/11 studies and averaged 91%.Patient-reported outcomes were extracted at last follow-up from 8 studies with an average visual analog scale of 1±1(range:0-2)and across 9 studies with an average Disabilities of the Arm,Shoulder and Hand score of 21±8(range:8-37).At last follow-up,the cumulative conversion rate to total wrist fusion averaged 6%.There were no conversions to total wrist arthroplasty.CONCLUSION The 4CF of the wrist is a reliable surgical technique,capable of achieving a good long-term patient satisfaction and survivorship with low rates of conversion to total wrist fusion. | Octavian Andronic Ladislav Nagy Marco D Burkhard Fabio A Casari Daniel Karczewski Philipp Kriechling Andreas Schweizer Lukas Jud | 2022 | World Journal of Orthopedics2022，13，1： | 0 |
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