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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 3 | Nitrogen metabolism and gas exchange parameters associated with zinc stress in tobacco expressing an ipt gene for cytokinin synthesis显示文摘 | Daniela Pavlíková Veronika Zemanová Dagmar Procházková Milan Pavlík Franti?ek Hnili?ka Na?a Wilhelmová | 2013 | Journal of Plant Physiology2013，，： | 1 |
| 4 | Organicsulfonic acid-functionalized mesoporous silicas for the esterification of fatty acid 显示文摘 | Mbaraka I K Daniela R R Lin V S | 2003 | Journal of Catalysis2003，219，： | 1 |
| 5 | Laparoscopic Approach to Colorectal Procedures in the Obese Patient: Risk Factor or Benefit?显示文摘 | Hubert Scheidbach Frank Benedix Omar Hügel Daniela Kose Ferdinand K?ckerling Hans Lippert | 2007 | Obesity Surgery2007，，1： | 1 |
| 6 | Asymbiotic seed germination, in vitro seedling development, and greenhouse acclimatizalion of the threatened terrestrial orchid Bletia purpurea 显示文摘 | Daniela D Timothy R J Philip J K | 2008 | Plant Cell Tiss and Organ Cult2008，94，： | 1 |
| 7 | Leaf shape evolution through duplication, regulatory diversification, and loss of a homeobox gene显示文摘 | Daniela V Daniel K Madlen I R | 2014 | Science2014，343，： | 1 |
| 8 | Cytochrome 2C19*17 allelic vari-ant ,platelet aggregation,bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement显示文摘 | Sibbing D Werner K Daniela G | 2010 | Circulation2010，121，4： | 1 |
| 9 | Safe and fast tetrazole formation in ionic liquids显示文摘 | Boris S Daniela M Daniel K | 2007 | Tetrahedron2007，63，2： | 1 |
| 10 | Preparation of gelatin and enzymic hydrolysates from sheep skin scraps 显示文摘 | Peter T N Daniela K B Pentsho G D | 1995 | Bulgarian Chemical Communications1995，28，1： | 1 |
| 11 | Perspectives of γδ T cells in tumor immunology 显示文摘 | Dieter K Daniela W Wei He | 2007 | Cancer Research2007，67，1： | 1 |
| 12 | Health effects of dietary phospholipids显示文摘 | DANIELA K ULLENBERG LENKA A TAYLOR MICHAEL SCHNEIDER | 2012 | Lipids in Health and Disease2012，11，1： | 1 |
| 13 | Influence of retrograde flushing via the caval vein on the post- reperfusion syndrome in liver transplantation 显示文摘 | DANIELA K MICHAEL Z FLORIAN I | 2004 | Clin Transplant2004，18，6： | 1 |
| 14 | Two acylated monoterpene glucosides from Paeonia peregina显示文摘 | Ivanka N K Mario F S Daniela I T | 1998 | Phytochemistry1998，48，3： | 1 |
| 15 | Evaluation of [ 18 F]-choline PET/CT for staging and restaging of prostate cancer显示文摘 | Daniela B. Husarik Raymond Miralbell Markus Dubs Hubert John Olivier T. Giger Albert Gelet Tibor Cservenyàk Thomas F. Hany | 2008 | European Journal of Nuclear Medicine and Molecular Imaging2008，，2： | 1 |
| 16 | Association of Changes in Bone Remodeling and Coronary Calcification in Hemodialysis Patients: A Prospective Study显示文摘 | Daniela Veit Barreto Fellype de Carvalho Barreto Aluízio Barbosa de Carvalho Lilian Cuppari Sérgio Antonio Draibe Maria Aparecida Dalboni Rosa Maria Affonso Moyses Kátia Rodrigues Neves Vanda Jorgetti Márcio Miname Raul D. Santos Maria Eugênia F. Canziani | 2008 | American Journal of Kidney Diseases2008，，6： | 1 |
| 17 | Mammalian type Ⅰ interferon receptors consists of two subunits:IFNaR1 and IFNaR2显示文摘 | Soo H K Batya C Daniela N | 1997 | Gene1997，196，： | 1 |
| 18 | Expression of Caveolin-1 induces premature cellular senescence in pri- mary cultures of murine fibroblasts Stress-induced pre- mature senescence upregulates the expression of endoge- nous caveolin-1显示文摘 | Daniela V Zhang K Michael P | 2002 | Molec Biol Cell2002，13，7： | 1 |
| 19 | Absorption of N-phenylpropenoyl-L amino acids in healthy humans by oral administration of cocoa 显示文摘 | Timo S Roman L Daniela K | 2008 | Mol Nutr Food Res2008，52，： | 1 |
| 20 | Degradation of FEP thermal control materials returned from the Hubble Space Telescope显示文摘 | ZUBY T M DE GROH K K DANIELA C S | 1995 | Proceedings of the Hubble Space Telescope Solar-Array Workshop Noordwijk The Netherlands1995，1995，： | 1 |
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