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| 1 | TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice显示文摘 | Zhidan Luo Liqun Ma Zhigang Zhao Hongbo He Dachun Yang Xiaoli Feng Shuangtao Ma Xiaoping Chen Tianqi Zhu Tingbing Cao Daoyan Liu Bernd Nilius Yu Huang Zhencheng Yan Zhiming Zhu | 2012 | Cell Research2012，22，3： | 18 |
| 2 | Imbalance and dysfunction of transient receptor potential channels contribute to the pathogenesis of hypertension显示文摘Intracellular Ca2+homeostasis is essential for vascular function and blood pressure regulation.Because of their unique roles in regulating intracellular Ca2+concentration and vascular function,a novel class of non-selective cation channels,called transient receptor potential(TRP)channels,have emerged at the frontier of hypertension research.Based on their role in vasculature function regulation,TRP channels can be divided into two functional subtypes:one that participates in vasoconstriction and one that participates in vasodilatation.A functional imbalance of these two subtypes of TRP channels may disturb intracellular calcium([Ca2+]i)homeostasis,and the consequent vascular dysfunction may contribute to the development of hypertension.The potential of these TRP channels as novel pharmacological targets for the treatment of human hypertension is of great interest. | LIU DaoYan XIONG ShiQiang ZHU ZhiMing | 2014 | Science China(Life Sciences)2014，57，8： | 4 |
| 3 | Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity显示文摘Brown adipose tissue(BAT)is an energy-expending organ that produces heat.Expansion or activation of BAT prevents obesity and diabetes.Chronic cold exposure enhances thermogenesis in BAT through uncoupling protein 1(UCP1)activation triggered via a b-adrenergic pathway.Here,we report that the cold-sensing transient receptor potential melastatin 8(TRPM8)is functionally present in mouse BAT.Challenging brown adipocytes with menthol,a TRPM8 agonist,up-regulates UCP1 expression and requires protein kinase A activation.Upon mimicking long-term cold exposure with chronic dietary menthol application,menthol significantly increased the core temperatures and locomotor activity in wild-type mice;these effects were absent in both TRPM82/2 and UCP12/2 mice.Dietary obesity and glucose abnormalities were also prevented by menthol treatment.Our results reveal a previously unrecognized role for TRPM8,suggesting that stimulation of this channel mediates BAT thermogenesis,which could constitute a promising way to treat obesity. | Shuangtao Ma Hao Yu Zhigang Zhao Zhidan Luo Jing Chen Yinxing Ni Rongbing Jin Liqun Ma Peijian Wang Zhenyu Zhu Li Li Jian Zhong Daoyan Liu Bernd Nilius Zhiming Zhu | 2012 | Journal of Molecular Cell Biology2012，4，2： | 2 |
| 4 | Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction显示文摘High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction. | Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 5 | Transient receptor potential vanilloid I activation by dietary capsaicin promotes urinary sodium excretion by inhibiting epithelial sodium channel α subunit-mediated sodium reabsorption显示文摘 | Li Li Wang FeiiWei Xing Liang Yi Cui Yuanting Gao Feng Zhong Jian Pu Yunfei Zhao Yu Yan Zhencheng Arendshorst William J Nilius Bemd Chen Jing'Liu Daoyan Zhu Zhiming | 2014 | Hypertension2014，642，： | 1 |
| 6 | Genome-Wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer显示文摘 | Zhihai Peng Fang Zhang Chongzhi Zhou Yun Ling Shaochun Bai Wanqing Liu Guoqiang Qiu Lin He Liwei Wang Daoyan Wei Edward Lin Keping Xie | 2003 | International Journal of Gastrointestinal Cancer2003，，1： | 1 |
| 7 | Atorvastatin Attenuates TNF-α–induced Increase of Glucose Oxidation Through PGC-1α Upregulation in Cardiomyocytes显示文摘 | Feng Gao Yinxing Ni Zhidan Luo Yi Liang Zhencheng Yan Xingsen Xu Daoyan Liu Jiang Wang Shanjun Zhu Zhiming Zhu | 2012 | Journal of Cardiovascular Pharmacology2012，，6： | 1 |
| 8 | Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome显示文摘 | Jian Zhong Zhengchen Yan Daoyan Liu Yinxing Ni Zhigang Zhao Shanjun Zhu Martin Tepel Zhiming Zhu | 2006 | The Journal of Laboratory and Clinical Medicine2006，，2： | 1 |
| 9 | Increased Transient Receptor Potential Canonical Type 3 Channels in Vasculature From Hypertensive Rats 显示文摘 | Daoyan Liu Daehun Yang Hongbo He | 2009 | Hypertension2009，53，： | 1 |
| 10 | Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity显示文摘 | ZHANG Lili LIU Daoyan MA Liqun | 2007 | Circulation Research2007，100，7： | 1 |
| 11 | 盐摄入通过PPARδ/脂联素介导的SGLT2通路调控糖稳态显示文摘高盐摄入是糖尿病发生高血压的主要危险因素.促进肾脏盐排泄可减少糖尿病的心血管损害,但摄盐与糖稳态的相互作用尚不清楚。 | Yu Zhao Peng Gao Fang Sun Qiang Li Jing Chen Hao Yu Li Li Xing Wei Hongbo He Zongshi Lu Xiao Wei Bin Wang Yuanting Cui Shiqiang Xiong Qianhui Shang Aimin Xu Yu Huang Daoyan Liu 祝之明 | 2017 | 科学新闻2017，19，4： | 0 |
| 12 | Production of monoclonal antibody and development of an enzyme-linked immunosorbent assay for the determination of okadaic acid in shellfish from China显示文摘 | Renyan LIU Bingjun CHEN Yubo LIANG Daoyan XU Bing LIANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 13 | Development of an enzyme-linked immunosorbent显示文摘 | Renyan LIU Bingjun CHEN Yubo LIANG Daoyan XU Bing LIANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 14 | Optimization and simultaneous heat integration design of a coal-based ethylene glycol refining process by a parallel differential evolution algorithm显示文摘Coal to ethylene glycol still lacks algorithm optimization achievements for distillation sequencing due to high-dimension and strong nonconvexity characteristics,although there are numerous reports on horizontal comparisons and process revamping.This scenario triggers the navigation in this paper into the simultaneous optimization of parameters and heat integration of the coal to ethylene glycol distillation scheme and double-effect superstructure by the self-adapting dynamic differential evolution algorithm.To mitigate the influence of the strong nonconvexity,a redistribution strategy is adopted that forcibly expands the population search domain by exerting external influence and then shrinks it again to judge the global optimal solution.After two redistributive operations under the parallel framework,the total annual cost and CO_(2) emissions are 0.61%/1.85%better for the optimized process and 3.74%/14.84%better for the superstructure than the sequential optimization.However,the thermodynamic efficiency of sequential optimization is 11.63%and 10.34%higher than that of simultaneous optimization.This study discloses the unexpected great energy-saving potential for the coal to ethylene glycol process that has long been unknown,as well as the strong ability of the self-adapting dynamic differential evolution algorithm to optimize processes described by the high-dimensional mathematical model. | Jiahao Wang Hao Lyu Daoyan Liu Chengtian Cui Jinsheng Sun | 2023 | Frontiers of Chemical Science and Engineering2023，17，9： | 0 |
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