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| 1 | Liver transplantation for alcoholic liver disease显示文摘Alcoholic liver disease(ALD) is the second commonest indication for liver transplantation after viral hepatitis in the United States and Europe.Controversies surround the indications and allocation of scarce and expensive resource for this so called self inflicted disease.Controversies stem from the apprehension that alcoholic recipients are likely to relapse and cause damage to the graft.There is a need to select those candidates with lower risk for relapse with the available predictive factors and scores.Substance abuse specialist and psychiatrists are mandatory in the pre-transplant evaluation and in the post-transplant follow-up.There is conflicting evidence to support a fixed period of pretransplant abstinence,although most units do follow this.Alcoholic hepatitis(AH) continues to be a contraindication for transplantation,however there is a need for further research in this f ield as a subset of patients with AH who do not respond to medical treatment,have high early mortality and could benefit from transplantation.One year,3-year,and 5-year survival post-transplant is similar for both ALD and non-ALD recipients.The incidence of post-transplant rejection and retransplantation is also similar to other recipients.ALD with viral hepatitis especially hepatitis C virus leads to a more aggressive liver disease with early presentation for transplantation.ALD patients are more prone to develop de-novo malignancy;this is attributed to the long term effect of alcohol,tobacco combined with immunosuppression.Post-transplant surveillance is important to detect early relapse to alcoholism,presence of de-novo malignancy and treat the same adequately. | Vibha Varma Kerry Webb Darius F Mirza | 2010 | World Journal of Gastroenterology2010，16，35： | 6 |
| 2 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 3 | Risk factors and surgical management of anastomotic biliary complications after pediatric liver transplantation显示文摘 | Darius T Rivera J Fusaro F | 2014 | Liver Transpl2014，20，8： | 1 |
| 4 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 5 | Environmental fate of triclosan in the River Aire Basin,UK显示文摘 | DARIUS S SIMON F W ARMIN H | 2003 | Water Research2003，37，13： | 1 |
| 6 | Color-coded perfused blood volume imaging using multidetector CT: initial results of whole-brain peffusion analysis in acute cerebral ischemia 显示文摘 | Stephan P Tobias F Darius G | 2007 | Eur Radiol2007，17，： | 1 |
| 7 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 8 | Environmental fate of Triclosan in the River Aire Basin,UK显示文摘 | Darius S Simon F W Armin H | 2003 | Water Res2003，37，13： | 1 |
| 9 | Open approach in pancreatic and infected pancreatic necrosis: Laparostomies and preplanned revisions显示文摘 | Reinhold Függer M.D. Franz Schulz M.D. Michael Rogy M.D. Friedrich Herbst M.D. Darius Mirza M.S. Arnulf Fritsch M.D | 1991 | World Journal of Surgery1991，，4： | 1 |
| 10 | CT angiography and perfusion CT in cerebral vasospasm after subarachnoid hemorrhage显示文摘 | Stephan P Tobias F Darius G | 2007 | AJNR2007，28，： | 1 |
| 11 | Color-coded perfused blood volume imaging using mnltidetector CT: initial results of whole-brain perfusion analysis in acute cerebral ischemia 显示文摘 | Stephan P Tobias F Darius G | 2007 | Eur Radiol2007，17，： | 1 |
| 12 | A review on current re- search trends in electrical discharge machining (EDM)显示文摘 | Norliana M A Darius G S Md F B | 2007 | In- ternational Journal of Machine Tools & Manufacture2007，47，78： | 1 |
| 13 | Sensitive capillary gas chromatograph- ic-mass spectrometric method for the therapeutic drug monitoring of valproic acid and seven of its metabolites in human serum : Ap- plication of the assay for a group of pediatric epileptics 显示文摘 | DARIUS J MEYER F P | 1994 | J Chromatogr B1994，656，2： | 1 |
| 14 | Mirza Colorectal cancer after orthotopic liver transplantation 显示文摘 | Michael A S Periyathambi S J Darius F | 2005 | Critical Reviews in Oncology/ Hematology2005，56，： | 1 |
| 15 | Risk factors and surgical management of anastomotic biliary complications after pediatric liver transplantation显示文摘 | Darius T Jairo R Fabio F | 2014 | Liver Transpl2014，20，8： | 1 |
| 16 | The management of coagulopathy and blood loss in liver surgery显示文摘 | Michael A Silva Vijayaragavan Muralidharan Darius F Mirza | 2004 | Seminars in Hematology2004，，： | 1 |
| 17 | Risk factors and surgical management of anastomotic biliary complications after pediatric liver transplantation显示文摘 | Darius T Rivera J Fusaro F | 2014 | Liver Transpl2014，20，8： | 1 |
| 18 | Late post liver transplant protein losing enteropathy: Rare complication of incisional hernia显示文摘Development of oedema and hypoproteinaemia in a liver transplant recipient may be the first signs of graft dysfunction and should prompt a full assessment. We report the novel case of a patient who, years after liver transplantation developed a functional blind loop in an incisional hernia, which manifested as oedema and hypoproteinaemia secondary to protein losing enteropathy. After numerous investigations, the diagnosis was made by flurodeoxyglucose positron emmision tomography (FDG-PET) imaging. Surgical repair of the incisional hernia was followed several months later by resolution of the protein loss, and confirmed at a post operative FDG-PET scan at one year. | Jonathan D Evans M Thamara PR Perera CY Pal James Neuberger Darius F Mirza | 2013 | World Journal of Gastroenterology2013，19，27： | 0 |
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