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| 1 | Systemic inflammatory response following acute myocardial infarction显示文摘在 infarcted 心的尖锐 cardiomyocyte 坏死产生联系损坏的分子的模式,激活表明,并且被触发强烈煽动性的回答的补充和像使用费的 receptor/interleukin-1。Inflammasomes 也认出危险信号并且调停跟随尖锐心肌的梗塞(AMI ) 的无菌的煽动性的反应。煽动性的反应服务修理心,但是过多的发炎导致不利左室的改变和心失败。除了局部炎症,深刻全身的发炎反应与 AMI 在病人被记录了,它包括传播煽动性的 cytokines, chemokines 和房间的举起外部白血球和血小板的粘附分子,和激活。过多的煽动性的反应能被一个 deregulated 免疫系统引起。AMI 也与骨头髓激活和怒气 monocytopoiesis 被联系,它在发炎的地点支撑单核白血球的连续供应。积累的证据证明了那全身的发炎加重动脉粥样硬化,为全身的发炎的标记是不利临床的结果的预言者(例如死亡,周期性的心肌的梗塞,和心失败) 在有 AMI 的病人。 | Lu FANG Xiao-Lei Moorea Anthony M Dart Le-Min WANG | 2015 | Journal of Geriatric Cardiology2015，12，3： | 36 |
| 2 | Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice显示文摘AIM: To optimize the experimental protocols for a simple, sensitive and accurate bleeding assay.METHODS: Bleeding assay was performed in mice by tail tip amputation, immersing the tail in saline at 37 ℃, continuously monitoring bleeding patterns and measuring bleeding volume from changes in the body weight. Sensitivity and extent of variation of bleeding time and bleeding volume were compared in mice treated with the P2 Y receptor inhibitor prasugrel at various doses or in mice deficient of Fc Rγ, a signaling protein of the glycoprotein VI receptor.RESULTS: We described details of the bleeding assay with the aim of standardizing this commonly used assay. The bleeding assay detailed here was simple to operate and permitted continuous monitoring of bleedingpattern and detection of re-bleeding. We also reported a simple and accurate way of quantifying bleeding volume from changes in the body weight, which correlated well with chemical assay of hemoglobin levels(r2 = 0.990, P < 0.0001). We determined by tail bleeding assay the dose-effect relation of the anti-platelet drug prasugrel from 0.015 to 5 mg/kg. Our results showed that the correlation of bleeding time and volume was unsatisfactory and that compared with the bleeding time, bleeding volume was more sensitive in detecting a partial inhibition of platelet's haemostatic activity(P < 0.01). Similarly, in mice with genetic disruption of Fc Rγ as a signaling molecule of P-selectin glycoprotein ligand-1 leading to platelet dysfunction, both increased bleeding volume and repeated bleeding pattern defined the phenotype of the knockout mice better than that of a prolonged bleeding time.CONCLUSION: Determination of bleeding pattern and bleeding volume, in addition to bleeding time, improved the sensitivity and accuracy of this assay, particularly when platelet function is partially inhibited. | Yang Liu Nicole L Jennings Anthony M Dart Xiao-Jun Du | 2012 | World Journal of Experimental Medicine2012，2，2： | 6 |
| 3 | Immune and inflammatory responses in subjects with stable angina and acute myocardial infarction显示文摘 | Lu FANG Anthony M Dart | 2015 | Journal of Geriatric Cardiology2015，12，3： | 3 |
| 4 | Large artery stiffness predicts ischemic threshold in patients with coronary artery disease显示文摘 | Bronwyn A Kingwell Tamara K Waddell Tanya L Medley James D Cameron Anthony M Dart | 2002 | Journal of the American College of Cardiology2002，，4： | 2 |
| 5 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 6 | Antiadrenergic effect of chronic amiodarone 显示文摘 | Kaye D M Dart A M Jennings G L | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 7 | Matrix metalloproteinase-9 contributes to choroidal neovascularization 显示文摘 | LAMBERT V MUNAUT C JOST M NOEL A WERB Z FOI- DART JM | 2002 | Am J Pathol2002，161，4： | 1 |
| 8 | Calcium in regolith carbonates of central and southern Aus- tralia: Its source and implications for the global carbon cy- cle 显示文摘 | DART R C BAROVICH K M CHITYLEBOROUGH D J | 2007 | Palaeogeogr Palaeoc]imatol Palaeoecol2007，249，34： | 1 |
| 9 | Modified activity-stress paradigm in an ani mal model of the female athlete triad显示文摘 | NANCY M DIMARCO LYN DART CHARLOTTE (BAR- NEY) SANBORN | 2007 | J Appl Physio2007，1103，： | 1 |
| 10 | Effect of hypother-mia on recovery from general anaesthesia in the dog显示文摘 | Pottie R G Dart C M Perkins N R | 2007 | AustVet J2007，85，4： | 1 |
| 11 | The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain 显示文摘 | Meyer MD Decker MW Rueter LE Anderson DJ Dart M J Kim KH | 2000 | Eur J Pharmacol2000，93，： | 1 |
| 12 | Smaller Aortic Dimensions donoffully Account for the greater pulse pressure in elderly female hypertensives 显示文摘 | DART A M KING BA GATZKA C D | 2008 | Hypertension2008，51，： | 1 |
| 13 | Extracapsular cataract extraction compared with small incision surgery by phacoemulsification: a randomized trial显示文摘 | Minassian DC Rosen P Dart JKG Reidy A Desai P Sidhu M | 2001 | Br J Ophthalmol2001，85，： | 1 |
| 14 | Severe serotonin syndrome from escitalopram over-dose 显示文摘 | Olsen D Dart RC Robinett M | 2004 | J Toxicol Clin Toxicol2004，42，7： | 1 |
| 15 | Successful treatment of transplant-associated mi- croangiopathy with rituximab显示文摘 | Mart H McDonald E J Merriman E Smith M Mangos H Stod- dart C | 2009 | NZ Med J2009，122，1292： | 1 |
| 16 | PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity显示文摘 | WHALE A D DART A HOLT M | 2013 | Oncogene2013，32，16： | 1 |
| 17 | The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain 显示文摘 | Decker MW Rueter LE Anderson DJ Dart M J Kim KH | 2000 | Eur J Pharmacol2000，393，13： | 1 |
| 18 | The fate of nitrogen applied to sugarcane by trickle irrlgation显示文摘 | Thorburn P J Dart I K Biggs I M | 2003 | Irrigation Science2003，22，： | 1 |
| 19 | Correction of carotid augmentation index for heart rate in elderly essential hypertensives显示文摘 | GATZKA C D CAMERON J D DART A M | 2001 | Am J Hypertens2001，14，4： | 1 |
| 20 | Large artery stiffness and baroreflex function 显示文摘 | Kingwell A CameronD Dart M | 2002 | Circulation2002，105，8： | 1 |
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