|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | Experimental study and analysis of an S-band multiple-beam klystron with 6% bandwidth显示文摘 | David A Dean P Nguyen K | 2009 | IEEE Trans on Electron Devices2009，56，5： | 1 |
| 3 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | 2013 (9908)2013，，9908： | 1 |
| 4 | Distribution, excretion, and metabolism of butylbenzyl phthalate in the rat显示文摘 | David A E Haig P B and Dean E C | 1986 | Journal of Toxicology and Environmental Health1986，17，4： | 1 |
| 5 | Blood Pressure and White-Matter Disease Progression in a Biethnic Cohort: Atherosclerosis Risk in Communities (ARIC) Study显示文摘 | Rebecca F. Gottesman Josef Coresh Diane J. Catellier A Richey Sharrett Kathryn M. Rose Laura H. Coker Dean K. Shibata David S. Knopman Clifford R. Jack Thomas H. Mosley | 2010 | Stroke2010，，1： | 1 |
| 6 | Podded destroyer propulsion 显示文摘 | Dean A R David J V Timothy J D | 1979 | Naval Engineering Journal1979，，4： | 1 |
| 7 | SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice显示文摘 | Yao Hongwei Chung Sangwoon Hwang Jae-woong Rajendrasozhan Saravanan Sundar Isaac K Dean David A McBurney Michael W Guarente Leonard Gu Wei R?nty Mikko Kinnula Vuokko L Rahman Irfan | 2012 | EN2012，，6： | 1 |
| 8 | Trace element analysis in hair:Factors determining accuracy,precision,and reliability显示文摘 | Dean A Darrell H David Q | 2001 | AlternMed Rev2001，6，5： | 1 |
| 9 | Toxicity of avermectins to Liriomyza trifolii (Diptera: Agromyzidae) lar- vae and adults显示文摘 | Cox David L Remick Dean M Lasota Joan A | 1995 | Journal of Economic Entomology1995，88，： | 1 |
| 10 | Financial slack and venture managers'decisions to seek a new alliance 显示文摘 | HOLGER PATZELT DEAN A SHEPHERD DAVID DEEDS etal | 2008 | Journal of Business Venturing2008，，23： | 1 |
| 11 | Efficacy of a diatomaceous earth against mite and insect populations in small bins of wheat under con- ditions of low temperature and high humidity 显示文摘 | Dean A Cook David M Armitage | 2000 | Pest Management Science2000，56，2： | 1 |
| 12 | Global health 2035: a world converging within a generation显示文摘 | Dean T Jamison Lawrence H Summers George Alleyne Kenneth J Arrow Seth Berkley Agnes Binagwaho Flavia Bustreo David Evans Richard G A Feachem Julio Frenk Gargee Ghosh Sue J Goldie Yan Guo Sanjeev Gupta Richard Horton Margaret E Kruk Adel Mahmoud Linah K Mo | 2013 | The Lancet . 2013 (9908)2013，，： | 1 |
| 13 | Fungal infection in surgical patients显示文摘 | David A Dean Kenneth W Burchard | 1996 | Am J Surg1996，171，： | 1 |
| 14 | Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children显示文摘 | Jon A Vanderhoof M D David B W M D Dean L A M D | 2006 | the journal of pediatrics2006，149，3： | 1 |
| 15 | Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children显示文摘 | Jon A Vanderhoof MD David B Whitney MD Dean L AntonsonMD | 1999 | The Journal of Pediatrics1999，135，5： | 1 |
| 16 | Relationships of hospitalization outcomes and timing to endoscopy in non-variceal upper gastrointestinal bleeding:A nationwide analysis显示文摘BACKGROUND The optimal timing of esophagogastroduodenoscopy(EGD)and the impact of clinico-demographic factors on hospitalization outcomes in non-variceal upper gastrointestinal bleeding(NVUGIB)remains an area of active research.AIM To identify independent predictors of outcomes in patients with NVUGIB,with a particular focus on EGD timing,anticoagulation(AC)status,and demographic features.METHODS A retrospective analysis of adult patients with NVUGIB from 2009 to 2014 was performed using validated ICD-9 codes from the National Inpatient Sample database.Patients were stratified by EGD timing relative to hospital admission(≤24 h,24-48 h,48-72 h,and>72 h)and then by AC status(yes/no).The primary outcome was all-cause inpatient mortality.Secondary outcomes included healthcare usage.RESULTS Of the 1082516 patients admitted for NVUGIB,553186(51.1%)underwent EGD.The mean time to EGD was 52.8 h.Early(<24 h from admission)EGD was associated with significantly decreased mortality,less frequent intensive care unit admission,shorter length of hospital stays,lower hospital costs,and an increased likelihood of discharge to home(all with P<0.001).AC status was not associated with mortality among patients who underwent early EGD(aOR 0.88,P=0.193).Male sex(OR 1.30)and Hispanic(OR 1.10)or Asian(aOR 1.38)race were also independent predictors of adverse hospitalization outcomes in NVUGIB.CONCLUSION Based on this large,nationwide study,early EGD in NVUGIB is associated with lower mortality and decreased healthcare usage,irrespective of AC status.These findings may help guide clinical management and would benefit from prospective validation. | Simcha Weissman Muhammad Aziz Ayrton I Bangolo Dean Ehrlich Arnold Forlemu Anthony Willie Manesh K Gangwani Danish Waqar Hannah Terefe Amritpal Singh Diego MC Gonzalez Jayadev Sajja Fatma L Emiroglu Nicholas Dinko Ahmed Mohamed Mark A Fallorina David Kosoy Ankita Shenoy Anvit Nanavati Joseph D Feuerstein James H Tabibian | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员