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| 1 | Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa显示文摘 | Julien Bertrand Alexis Goichon Philippe Chan Saida Azhar Stéphane Lecleire Nathalie Donnadieu David Vaudry Anne-Fran?oise Cailleux Pierre Déchelotte Mo?se Co?ffier | 2014 | Amino Acids2014，，4： | 1 |
| 2 | Modeling the dynamically tuned gyroscope in support of high-bandwidth capture loop design显示文摘 | David(Raytheon Ststems Co) | 1999 | Proceedings of SPIE-The International Society for Optical Engineering1999，3692，： | 1 |
| 3 | Military satellite : Space-based for the global information grid 显示文摘 | David A F Bharat T D Andrew CO | 2006 | JohnsHopkins APL Technical Digest2006，27，1： | 1 |
| 4 | Determination of denitrification genes abundance in environmental samples显示文摘 | Eulogio JB David Co German T | 2013 | Metagenomics2013，，2： | 1 |
| 5 | Clinical practice guideline: Adult sinusitis显示文摘 | Richard M. Rosenfeld David Andes Neil Bhattacharyya Dickson Cheung Steven Eisenberg Theodore G. Ganiats Andrea Gelzer Daniel Hamilos Richard C. Haydon Patricia A. Hudgins Stacie Jones Helene J. Krouse Lawrence H. Lee Martin C. Mahoney Bradley F. Marple Co | 2007 | Otolaryngology - Head and Neck Surgery2007，，3： | 1 |
| 6 | Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice显示文摘BACKGROUND Irritable bowel syndrome and bladder pain syndrome often overlap and are both characterized by visceral hypersensitivity.Since pelvic organs share common sensory pathways,it is likely that those syndromes involve a cross-sensitization of the bladder and the colon.The precise pathophysiology remains poorly understood.AIM To develop a model of chronic bladder-colon cross-sensitization and to investigate the mechanisms involved.METHODS Chronic cross-organ visceral sensitization was obtained in C57BL/6 mice using ultrasound-guided intravesical injections of acetic acid under brief isoflurane anesthesia.Colorectal sensitivity was assessed in conscious mice by measuring intracolonic pressure during isobaric colorectal distensions.Myeloperoxidase,used as a marker of colorectal inflammation,was measured in the colon,and colorectal permeability was measured using chambers.c-Fos protein expression,used as a marker of neuronal activation,was assessed in the spinal cord(L6-S1 level)using immunohistochemistry.Green fluorescent protein on the fractalkine receptor-positive mice were used to identify and count microglia cells in the L6-S1 dorsal horn of the spinal cord.The expression of NK1 receptors and MAPK-p38 were quantified in the spinal cord using western blot.RESULTS Visceral hypersensitivity to colorectal distension was observed after the intravesical injection of acetic acid vs saline(P<0.0001).This effect started 1 h post-injection and lasted up to 7 d postinjection.No increased permeability or inflammation was shown in the bladder or colon 7 d postinjection.Visceral hypersensitivity was associated with the increased expression of c-Fos protein in the spinal cord(P<0.0001).In green fluorescent protein on the fractalkine receptor-positive mice,intravesical acetic acid injection resulted in an increased number of microglia cells in the L6-S1 dorsal horn of the spinal cord(P<0.0001).NK1 receptor and MAPK-p38 levels were increased in the spinal cord up to 7 d after injection(P=0.007 and 0.023 respectively).Colorectal sensitization was prevented by intrathecal or intracerebroventricular injections of minocycline,a microglia inhibitor,by intracerebroventricular injection of CP-99994 dihydrochloride,a NK1 antagonist,and by intracerebroventricular injection of SB203580,a MAPK-p38 inhibitor.CONCLUSION We describe a new model of cross-organ visceral sensitization between the bladder and the colon in mice.Intravesical injections of acetic acid induced a long-lasting colorectal hypersensitivity to distension,mediated by neuroglial interactions,MAPK-p38 phosphorylation and the NK1 receptor. | Karim Atmani Fabien Wuestenberghs Maximilien Baron Illona Bouleté Charlène Guérin Wafa Bahlouli David Vaudry Jean Claude do Rego Jean-Nicolas Cornu Anne-Marie Leroi Moïse Coëffier Mathieu Meleine Guillaume Gourcerol | 2022 | World Journal of Gastroenterology2022，28，48： | 1 |
| 7 | Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of there normal countreparts显示文摘 | David V Cecile CO Valerie C | 2002 | Breast Cancer Research and Treatment2002，76，： | 1 |
| 8 | Irrigation scheduling for traditional, low-density ol ive orchards: Water relations and influence on oil characteris tics 显示文摘 | Alfonso Moriana David Pe'rez-Lo'pez Aurora Go'mez Ri co etal | 2006 | Agricultural water management2006，87，： | 1 |
| 9 | Water Vapor Variability in the Tropical Western Pacific from 20-year Radiosonde Data显示文摘The 20-year (1976-1995) daily radinsonde data at 17 stations in the tropical western Pacific was ana- lyzed. The analysls shows that the atmosphere is more humid in a warmer climate on seasonal,inter-annual and long-term (20-year) time scales, implying a positive water vapor feedback The vertlcal structure of the long-term trends in relative humidity (RH) is distinct from that on short-term (seasonal and inter-annual) time scales, suggesting that observed water vapor changes on short time scales could not be considered as a surrogate of long-term climate change. The increasing trend of RH (3%-5% / decade) in the upper troposphere is stronger than that in the lower troposphere (1 %-2% / decade). Such verthal structure would amplify positive water vapor feedback in comparison to the common assumption of constant RH changes vertically. The empicical orthogonal function (EOF) analysis of vertical structure of RH varmtions shows distinct features of the vert1cal structure of the first three EOFs. The first three EOFs are optimal for repre- sentation of water vapor profiles and provide some hints on physical mechanisms respons1ble for observed humidity variability. Vaisala radiosondes were used at nine stations, and VIZ radiosondes used at other eight stations The Vaisala data are corrected for temperature-dependence error using the correction siheme developed by NCAR / ATD and Vaisala. The comparison of Vaisala and VIZ data shows that the VIZ-measured RHs after October 1993 have a moist bias of - 10% at RHs < 20%. During 1976-1995, several changes in- cluding both instruments and reporting practice have been made at Vaisala stations and introduce errors to long-term RH variations. | Junhong Wang, Harold L. Cole and David J. Carlson National Center for Atmospheric Research P. O, Box 3000,Boulder, CO 80307 | 2001 | Advances in Atmospheric Sciences2001，18，5： | 0 |
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