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| 1 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 2 | Role of the complement cascade in cerebral aneurysm formation,growth,and rupture显示文摘Rupture of intracranial aneurysms is the most common cause of nontraumatic subarachnoid hemorrhage,but the intricate neuroinflammatory processes which contribute to aneurysm pathophysiology are not well‑understood.Mounting evidence has implicated the complement cascade in the progression of aneurysms from their formation to rupture.In this article,we identify and review studies that have sought to determine the role of the complement system in the aneurysm pathogenesis.The studies were generally conducted by immunhistological analyses on aneurysm tissue collected intraoperatively,and multiple components of the complement cascade and its modulators were identified in specific regions of the aneurysm wall.The results of the studies suggest that the complement cascade is locally upregulated and disinhibited in the perianeurysmal environment,and that it contributes to chronic as well as acute immunological damage to the aneurysm wall.In the future,understanding the mechanisms at work in complement‑mediated damage is necessary to leading the development of novel therapies. | Blake E.S.Taylor Geoff Appelboom Robert Zilinyi Ariana Goodman David Chapel Melissa LoPresti Edward Sander Connolly Jr. | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 2 |
| 3 | Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: Results from the Canadian Registry of Atrial Fibrillation显示文摘 | Charles R. Kerr Karin H. Humphries Mario Talajic George J. Klein Stuart J. Connolly Martin Green John Boone Robert Sheldon Paul Dorian David Newman | 2005 | American Heart Journal2005，，3： | 2 |
| 4 | Challenges in the Detection and Attribution of Northern Hemisphere Surface Temperature Trends Since 1850显示文摘Since 2007,the Intergovernmental Panel on Climate Change(IPCC)has heavily relied on the comparison between global climate model hindcasts and global surface temperature(ST)estimates for concluding that post-1950s global warming is mostly human-caused.In Connolly et al.,we cautioned that this approach to the detection and attribution of climate change was highly dependent on the choice of Total Solar Irradiance(TSI)and ST data sets.We compiled 16 TSI and five ST data sets and found by altering the choice of TSI or ST,one could(prematurely)conclude anything from the warming being“mostly human-caused”to“mostly natural.”Richardson and Benestad suggested our analysis was“erroneous”and“flawed”because we did not use a multilinear regression.They argued that applying a multilinear regression to one of the five ST series re-affirmed the IPCC's attribution statement.They also objected that many of the published TSI data sets were out-of-date.However,here we show that when applying multilinear regression analysis to an expanded and updated data set of 27 TSI series,the original conclusions of Connolly et al.are confirmed for all five ST data sets.Therefore,it is still unclear whether the observed warming is mostly human-caused,mostly natural or some combination of both. | Ronan Connolly Willie Soon Michael Connolly Sallie Baliunas Johan Berglund C.J.Butler Rodolfo Gustavo Cionco Ana G.Elias Valery M.Fedorov Hermann Harde Gregory W.Henry Douglas V.Hoyt Ole Humlum David R.Legates Nicola Scafetta Jan-Erik Solheim LászlóSzarka Víctor M.Velasco Herrera Hong Yan Weijia Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，10： | 1 |
| 5 | How much has the Sun influenced Northern Hemisphere temperature trends?An ongoing debate显示文摘In order to evaluate how much Total Solar Irradiance(TSI)has influenced Northern Hemisphere surface air temperature trends,it is important to have reliable estimates of both quantities.Sixteen different estimates of the changes in TSI since at least the 19th century were compiled from the literature.Half of these estimates are'low variability'and half are'high variability'.Meanwhile,five largely-independent methods for estimating Northern Hemisphere temperature trends were evaluated using:1)only rural weather stations;2)all available stations whether urban or rural(the standard approach);3)only sea surface temperatures;4)tree-ring widths as temperature proxies;5)glacier length records as temperature proxies.The standard estimates which use urban as well as rural stations were somewhat anomalous as they implied a much greater warming in recent decades than the other estimates,suggesting that urbanization bias might still be a problem in current global temperature datasets-despite the conclusions of some earlier studies.Nonetheless,all five estimates confirm that it is currently warmer than the late 19th century,i.e.,there has been some'global warming'since the 19th century.For each of the five estimates of Northern Hemisphere temperatures,the contribution from direct solar forcing for all sixteen estimates of TSI was evaluated using simple linear least-squares fitting.The role of human activity on recent warming was then calculated by fitting the residuals to the UN IPCC’s recommended'anthropogenic forcings'time series.For all five Northern Hemisphere temperature series,different TSI estimates suggest everything from no role for the Sun in recent decades(implying that recent global warming is mostly human-caused)to most of the recent global warming being due to changes in solar activity(that is,that recent global warming is mostly natural).It appears that previous studies(including the most recent IPCC reports)which had prematurely concluded the former,had done so because they failed to adequately consider all the relevant estimates of TSI and/or to satisfactorily address the uncertainties still associated with Northern Hemisphere temperature trend estimates.Therefore,several recommendations on how the scientific community can more satisfactorily resolve these issues are provided. | Ronan Connolly Willie Soon Michael Connolly Sallie Baliunas Johan Berglund C.John Butler Rodolfo Gustavo Cionco Ana G.Elias Valery M.Fedorov Hermann Harde Gregory W.Henry Douglas V.Hoyt Ole Humlum David R.Legates Sebastian Liming Nicola Scafetta Jan-Erik Solheim Laszlo Szarka Harry van Loon Victor M.Velasco Herrera Richard C.Willson 晏宏 Weijia Zhang | 2021 | Research in Astronomy and Astrophysics2021，21，6： | 1 |
| 6 | Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency显示文摘 | GROTZ N FOX T CONNOLLY E PARK W GUERINOT M L DAVID E | 1998 | Proceedings of the National Academy of Sciences of the United States of America1998，95，： | 1 |
| 7 | Accuracy of Physical Activity Monitors in Pregnant Women显示文摘 | CHRISTOPHER P. CONNOLLY DAWN P. COE JO M. KENDRICK DAVID R. BASSETT DIXIE L. THOMPSON | 2011 | Medicine & Science in Sports & Exercise2011，，6： | 1 |
| 8 | Complement Component C3 Mediates Inflammatory Injury Following Focal Cerebral Ischemia显示文摘 | J Mocco William J. Mack Andrew F. Ducruet Sergei A. Sosunov Michael E. Sughrue Benjamin G. Hassid M Nathan Nair Ilya Laufer Ricardo J. Komotar M Claire H. Holland David J. Pinsky E Sander Connolly | 2006 | Circulation Research2006，，： | 1 |
| 9 | Closed system endotracheal suctioning maintains lung volume during volume controlled mechanical ventilation显示文摘 | David Pogson Peter Shirley Elizabeth Connolly | 2002 | Intensive Care Med2002，28，2： | 1 |
| 10 | Effect of Operation for Ebstein Anomaly on Left Ventricular Function显示文摘 | Morgan L. Brown Joseph A. Dearani Gordon K. Danielson Frank Cetta Heidi M. Connolly Carole A. Warnes Zhuo Li David O. Hodge David J. Driscoll | 2008 | The American Journal of Cardiology2008，，12： | 1 |
| 11 | Functional Status After Operation for Ebstein Anomaly显示文摘 | Morgan L. Brown Joseph A. Dearani Gordon K. Danielson Frank Cetta Heidi M. Connolly Carole A. Warnes Zhuo Li David O. Hodge David J. Driscoll | 2008 | Journal of the American College of Cardiology2008，，6： | 1 |
| 12 | Geohazard detection and other applications of chimney cubes显示文摘 | Fred Aminzadeh David Connolly Roar Heggland | 2002 | The Leading Edge2002，，7： | 1 |
| 13 | Chimney detection and interpretation,revealing sealing quality of faults,geohazards,charge of and leakage from reservoirs显示文摘 | Herald Ligtenberg David Connolly | 2003 | Journal of Geochemical Exploration2003，，： | 1 |
| 14 | Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease显示文摘 | Denise C Connolly David L Greenspan Rong Wu | 2000 | Clin Cancer Res2000，6，： | 1 |
| 15 | Inferior wall myocardial infarction caused by anomalous right coronary artery显示文摘 | Kirk Sloan David Majdalany Heidi Connolly Hartzell Schaff | 2008 | Canadian Journal of Cardiology2008，，： | 1 |
| 16 | GREENHOUSE GAS AND AMMONIA EMISSION MITIGATION PRIORITIES FOR UK POLICY TARGETS显示文摘Agriculture is essential for providing food and maintaining food security while concurrently delivering multiple other ecosystem services. However,agricultural systems are generally a net source of greenhouse gases and ammonia. They, therefore, need to substantively contribute to climate change mitigation and net zero ambitions. It is widely acknowledged that there is a need to further reduce and mitigate emissions across sectors, including agriculture to address the climate emergency and emissions gap. This discussion paper outlines a collation of opinions from a range of experts within agricultural research and advisory roles following a greenhouse gas and ammonia emission mitigation workshop held in the UK in March 2022. The meeting identified the top mitigation priorities within the UK's agricultural sector to achieve reductions in greenhouse gases and ammonia that are compatible with policy targets. In addition, experts provided an overview of what they believe are the key knowledge gaps, future opportunities and cobenefits to mitigation practices as well as indicating the potential barriers to uptake for mitigation scenarios discussed. | Sarah BUCKINGHAM Cairistiona F.E.TOPP Pete SMITH Vera EORY David R.CHADWICK Christina K.BAXTER Joanna M.CLOY Shaun CONNOLLY Emily C.COOLEDGE Nicholas J.COWAN Julia DREWER Colm DUFFY Naomi JFOX Asma JEBARI Becky JENKINS Dominika J.KROL Karina A.MARSDEN Graham A.MCAULIFFE Steven J.MORRISON Vincent O'FLAHERTY Rachael RAMSEY Karl G.RICHARDS Rainer ROEHE Jo SMITH Kate SMITH Taro TAKAHASHI Rachel E.THORMAN John WILLIAMS Jeremy WILTSHIRE Robert M.REES | 2023 | Frontiers of Agricultural Science and Engineering2023，10，2： | 0 |
| 17 | How reproductive allocation and flowering probability of individuals in plant populations are affected by position in stand size hierarchy,plant size and CO_(2) regime显示文摘Aims We investigate the effect of position within a size-structured population on the reproductive allocation(RA)and flowering probability of individual plants of Sinapis arvensis.We also assess the effects of plant size and changing level of CO_(2) on both responses.Methods Sinapis arvensis L.,(field mustard),an annual agricultural weed,was grown in monoculture at six densities under ambient and elevated CO_(2) in a study with 84 stands.Individual aboveground biomass and reproductive biomass were measured.Varying density produced a wide range of mean plant sizes across stands and size hierarchies within stands.Many(;40%)individuals had zero reproductive biomass.Employing a novel modelling approach,we analysed the joint effects of position in stand size hierarchy,plant size and CO_(2) on RA and flowering probability of individuals.Important Findings We found a strong effect of position within the size hierarchy of individuals in a population:for an individual of a given size,greater size relative to neighbours substantially increased RA and flowering probability at a single harvest time.There was no other effect of plant size on RA.We found a positive effect of elevated CO_(2) on RA regardless of position within the size hierarchy.These observed patterns could impact doubly on the reproductive biomass(R)of small individuals.First,because RA is not affected by size,smaller plants will have smaller R than larger plants;and second,for smaller plants lower down in a population size hierarchy,their RA and hence R will be further reduced.These results suggest that size relative to neighbours may be independent of and more important than direct abiotic effects in determining RA.Further studies are required to evaluate how these observed patterns generalize to other populations in non-experimental conditions. | Caroline Brophy David J.Gibson Peter M.Wayne John Connolly | 2008 | Journal of Plant Ecology2008，1，4： | 0 |
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