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| 1 | 卒中治疗专业学术圆桌会议临床前推荐更新版显示文摘首份卒中治疗专业学术圆桌会议(Stroke Yherapy Academic Industry Roundtable,STAIR)推荐于1999年出版,旨在提高潜在的急性卒中治疗方法的临床前研究质量。虽然这些推荐意见被认为是合理的,但并未得到严格的遵循和验证。为了更好地向临床转化,有关候选急性卒中疗法的临床前试验的质量和广度已取得实质性进展。更新后的STAIR临床前推荐进一步强调了最初提出的建议,即通过适当的生理学监测在多种动物物种中采用组织学和功能结局来确定可重复的剂量反应和时间窗。更新后的STAIR推荐意见包括:高质量科学研究的基本原则应消除随机和评价偏倚,预先确定纳入和排除标准,计算合适的效能和样本量,并公开潜在的利益冲突。应在年轻的健康雄性动物中进行初步评价之后,在雌性、高龄动物和伴有合并症(如高血压、糖尿病和高胆固醇血症)的动物中做进一步研究。此外还要在动物实验中应用临床相关生物学标志物。尽管只有通过临床试验产生基于此的有效疗法之后才能证实该推荐意见的有效性,但遵循这些推荐有望提高成功的机会。 | Marc Fisher Giora Feuerstein David W. Howells Patricia D. Hum Thomas A. Kent Sean I. Savitz Eng H. Lo 吕志宿(译) 罗本燕(译) | 2009 | 国际脑血管病杂志2009，17，8： | 5 |
| 2 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 3 | SJES14110700383743显示文摘 | Peter J. Murray Judith E. Allen Subhra K. Biswas Edward A. Fisher Derek W. Gilroy Sergij Goerdt Siamon Gordon John A. Hamilton Lionel B. Ivashkiv Toby Lawrence Massimo Locati Alberto Mantovani Fernando O. Martinez Jean-Louis Mege David M. Mosser Gioacchin | 2014 | Immunity2014，，1： | 2 |
| 4 | Emissive displays with transfer-printed assemblies of 8 μm × 15 μm inorganic light-emitting diodes显示文摘Displays using direct light emission from microscale inorganic light-emitting diodes(μILEDs)have the potential to be very bright and also very power efficient.High-throughput technologies that accurately and cost-effectively assemble microscale devices on display substrates with high yield are key enablers forμILED displays.Elastomer stamp transfer printing is such a candidate assembly technology.A variety ofμILED displays have been designed and fabricated by transfer printing,including passive-matrix and active-matrix displays on glass and plastic substrates. | CHRISTOPHER A.BOWER MATTHEW A.MEITL BROOK RAYMOND ERICH RADAUSCHER RONALD COK SALVATORE BONAFEDE DAVID GOMEZ TANYA MOORE CARL PREVATTE BRENT FISHER ROBERT ROTZOLL GEORGE A.MELNIK ALIN FECIORU ANTóNIO JOSé TRINDADE | 2017 | Photonics Research2017，5，2： | 2 |
| 5 | Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 1 diabetes (BEGIN Basal-Bolus Type 1): a phase 3, randomised, open-label, treat-to-target non-inferiority trial显示文摘 | Simon Heller John Buse Miles Fisher Satish Garg Michel Marre Ludwig Merker Eric Renard David Russell-Jones Areti Philotheou Ann Marie Ocampo Francisco Huiling Pei Bruce Bode | 2012 | The Lancet2012，，9825： | 2 |
| 6 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 7 | 治疗选择偏倚的存在与观察性研究分析:使用倾向积分法和工具变量法评价心脏介入治疗对AMI存活的影响显示文摘背景:对观察性研究中治疗与未治疗患者的结果进行比较时,由于患者预后存在组间差异,因此可发生偏倚,后者常常是因为存在未予观察的治疗选择偏倚。
目的:对下列4种去除观察性研究选择偏倚的分析方法进行比较:多变量模型危险校正法(muhivariable model risk adjustment)、倾向积分危险校正法(propensity score risk adjustment)、倾向匹配法(propensity—based matching)以及工具变量分析法(instrumental variable analysis)。
设计、地点及患者:122124例因急性心肌梗死(AMI)而于1994~1995年住院的、接受医疗保险的老年(年龄65~84岁)患者全国队列。这些患者适合心脏导管检查。基线图表审查取自心血管协作项目并与医疗保险健康管理数据联合以便提供系列预后变量。患者随访7年(至2001年12月31日)以便评估长期存活与住院30天内心脏导管检查两者的关系。
主要观测指标:使用各种分析方法获得的危险校正后相对死亡率。
结果:与未接受心导管检查的患者相比,接受心导管检检查的患者较年轻而且急性心肌梗死的严重度较低。采用标准的统计学危险校正法校正预后因素后,心导管检查与死亡率相对下降50%相关(多变量模型危险矫正法:校正后相对危险度[relative risk,RR],〉0.51;95%可信区间[confidence interval,CI],0.50~0.52。倾向积分危险校正法:校正后RR,0.54;95%CI,0.53~0.55]。倾向配对法:校正后RR,0.54;95%CI,0.52~0.56)。使用局部插管作为一种工具,工具变量分析显示死亡率相对下降16%(校正后RR,0.84;95%CI,0.79~0.90)。随机临床试验中常规介入治疗的生存获益在8%和21%之间。
结论:心导管检查与急性心肌梗死长期死亡率的关系对分析方法高度敏感。对于去除未测量的治疗选择偏倚而言,各种标准危险校正方法具有同样的局限。与标准建模法比较,工具变量分析法可以减少治疗效果偏倚。但是相对于特殊的临床问题,该法更适合回答政策策略问题。 | Thérèse A. Stukel Elliott S. Fisher David E. Wennberg 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，6： | 2 |
| 8 | Management of antithrombotic agents for endoscopic procedures显示文摘 | Michelle A. Anderson Tamir Ben-Menachem S. Ian Gan Vasundhara Appalaneni Subhas Banerjee Brooks D. Cash Laurel Fisher M. Edwyn Harrison Robert D. Fanelli Norio Fukami Steven O. Ikenberry Rajeev Jain Khalid Khan Mary Lee Krinsky David R. Lichtenstein John | 2009 | Gastrointestinal Endoscopy2009，，6： | 2 |
| 9 | Laparoscopic Distal Pancreatectomy: Trends and Lessons Learned Through an 11-Year Experience显示文摘 | Peter J. Kneuertz Sameer H. Patel Carrie K. Chu Sarah B. Fisher Shishir K. Maithel Juan M. Sarmiento Sharon M. Weber Charles A. Staley David A. Kooby | 2012 | Journal of the American College of Surgeons2012，，2： | 2 |
| 10 | Proboscis lateralis: a rare craniofaeial anomaly, reconstruction, and long-term evaluation 显示文摘 | David LR Sanger C Fisher D | 2008 | J Craniofae Surg2008，19，： | 1 |
| 11 | HER2 in resected gastric cancer: Is there prognostic value?显示文摘 | Sarah B. Fisher Kevin E. Fisher Malcolm H. Squires Sameer H. Patel David A. Kooby Bassel F. El‐Rayes Kenneth Cardona Maria C. Russell Charles A. Staley Alton B. Farris Shishir K. Maithel | 2014 | J Surg Oncol2014，，2： | 1 |
| 12 | Anticoagulation/Thrombosis: Reversal of Heparin Anticoagulation by Recombinant Platelet Factor 4 in Humans显示文摘 | Gregory J. Dehmer Melrose Fisher David A. Tate Steve Teo Eric M. Bonnem | 1995 | Circulation1995，，8： | 1 |
| 13 | Update of the stroke therapy academic industry roundtable preclinical recommen- dations显示文摘 | FISHER M FEUERSTEIN G DAVID W | 2009 | Stroke2009，40，6： | 1 |
| 14 | Presentation and Management of Gastrointestinal Stromal Tumors of the Duodenum: A Multi-Institutional Analysis显示文摘 | Fabian Johnston Peter Kneuertz John Cameron Dominic Sanford Sarah Fisher Ryan Turley Ryan Groeschl Omar Hyder David Kooby Dan Blazer Michael Choti Christopher Wolfgang T. Gamblin William Hawkins Shishir Maithel Timothy Pawlik | 2012 | Annals of Surgical Oncology2012，，11： | 1 |
| 15 | Bilateral buccal flaps with double opposingZ-plasty for wider palatal clefts 显示文摘 | Robert J Mann David M Fisher | 1997 | Plast Reconstr Surg1997，100，5： | 1 |
| 16 | Phase I Trial of Intravesical Recombinant Adenovirus Mediated Interferon-α2b Formulated in Syn3 for Bacillus Calmette-Guérin Failures in Nonmuscle Invasive Bladder Cancer显示文摘 | Colin P.N. Dinney Mark B. Fisher Neema Navai Michael A. O’Donnell David Cutler Alice Abraham Sophia Young Beth Hutchins Maria Caceres Narendra Kishnani George Sode Constance Cullen Guangcheng Zhang H. Barton Grossman Ashish M. Kamat Marshall Gonzales Mich | 2013 | The Journal of Urology2013，，： | 1 |
| 17 | Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma显示文摘 | Carmit Levy Mehdi Khaled Dimitrios Iliopoulos Maja M. Janas Steffen Schubert Sophie Pinner Po-Hao Chen Shuqiang Li Anne L. Fletcher Satoru Yokoyama Kenneth L. Scott Levi A. Garraway Jun S. Song Scott R. Granter Shannon J. Turley David E. Fisher Carl D. No | 2010 | Molecular Cell2010，，5： | 1 |
| 18 | MITF: master regulator of melanocyte development and melanoma oncogene显示文摘 | Carmit Levy Mehdi Khaled David E. Fisher | 2006 | Trends in Molecular Medicine2006，，9： | 1 |
| 19 | Effect of Cardiac Resynchronization Therapy on Left Ventricular Size and Function in Chronic Heart Failure显示文摘 | Martin G. St John Sutton Ted Plappert William T. Abraham Andrew L. Smith David B. DeLurgio Angel R. Leon Evan Loh Dusan Z. Kocovic Westby G. Fisher Myrvin Ellestad John Messenger Kristin Kruger Kathryn E. Hilpisch Michael R.S. Hill | 2003 | Circulation: Journal of the American Heart Association2003，，： | 1 |
| 20 | The Influences: New approaches for analysing influ- ence on twitter 显示文摘 | Alex Leavitt Evan Burchard David Fisher and Sam Gil- bert | 2009 | Web Ecology Project2009，4，2： | 1 |
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