|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Atherosclerosis in the human branchial artery显示文摘 | Kristensen IB David S | 1997 | J Am Coll Cardiol1997，29，： | 1 |
| 2 | Atherosclerosis in the human branchial artery显示文摘 | Sorensen KE Kristensen IB David S Celermajor DS | 1997 | J Am Coll Cardiol1997，29，： | 1 |
| 3 | Regulation of signal transduction by reactive oxygen species in the cardiovascular system显示文摘 | David IB Kathy KG | 2015 | Circ Res2015，116，： | 1 |
| 4 | Treatment of Distal Radius Fractures显示文摘 | David ML Randipsingh RB Martin IB | 2010 | Am Acad Orthop Surg2010，，18： | 1 |
| 5 | A review on the latest development of carbon membranes for gas separation显示文摘 | Ismail A F David L IB | 2001 | J Membr Sci2001，193，： | 1 |
| 6 | Metabolic profiling of four synthetic stimulants,including the novel indanyl-cathinone 5-PPDi,after human hepatocyte incubation显示文摘Synthetic cathinones are new psychoactive substances that represent a health risk worldwide.For most of the 130 reported compounds,information about toxicology and/or metabolism is not available,which hampers their detection(and subsequent medical treatment)in intoxication cases.The principles of forensic analytical chemistry and the use of powerful analytical techniques are indispensable for stab-lishing the most appropriate biomarkers for these substances.Human metabolic fate of synthetic cathinones can be assessed by the analysis of urine and blood obtained from authentic consumers;however,this type of samples is limited and difficult to access.In this work,the metabolic behaviour of three synthetic cathinones(4-CEC,4-CPrC and 5-PPDi)and one amphetamine(3-FEA)has been evalu-ated by incubation with pooled human hepatocytes and metabolite identification has been performed by high-resolution mass spectrometry.This in vitro approach has previously shown its feasibility for obtaining excretory human metabolites.4-CEC and 3-FEA were not metabolised,and for 4-CPrC only two minor metabolites were obtained.On the contrary,for the recently reported 5-PPDi,twelve phase I metabolites were elucidated.Up to our knowledge,this is the first metabolic study of an indanyl-cathinone.Data reported in this paper will allow the detection of these synthetic stimulants in intoxi-cation cases,and will facilitate future research on the metabolic behaviour of other indanyl-based cathinones. | David Fabregat-Safont Marie Mardal Juan V.Sancho Félix Hernández Kristian Linnet María Ibánez | 2020 | Journal of Pharmaceutical Analysis2020，10，2： | 0 |
| 7 | GABA_B受体的最新进展:从药理学到分子生物学(英文)显示文摘Bicuculline-insensitive receptors for the inhibitory neurotransmitter γ-aminobutyric acid (GABA), GABAB receptors, are a distinct subclass of receptors that mediate depression of synaptic transmission and contribute to neu-ronal inhibition. When activated, these receptors reduce transmission at excitatory and inhibitory synapses, as a result of an increase in K+ conductance, or a decrease in voltage-dependent Ca2+ currents. They are also linked to G-proteins, or intracellular effector systems in a very complex manner. The recent development of highly specific and potent agonists and antagonists for these receptors has led to a much better understanding of their physiology and pharmacology, including their heterogeneity, as well as their molecular biology. Over the past year, expression and cloning studies have contributed to major advances in characterizing GABAB receptor structure, with the discovery of the amino acid sequences of GABABRla/R1b splice variants and GABABR2 receptors. These isoforms | Jennifer ONG David IB KERR | 2000 | Acta Pharmacologica Sinica2000，21，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员