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| 1 | Immunopathogenesis of inflammatory bowel disease显示文摘Crohn’s disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn’s disease and T-helper-2 mediated condition in ulcerative colitis. Recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis. | David Q Shih Stephan R Targan | 2008 | World Journal of Gastroenterology2008，14，3： | 44 |
| 2 | Immunopathology of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)results from a complex series of interactions between susceptibility genes,the environment,and the immune system.The host microbiome,as well as viruses and fungi,play important roles in the development of IBD either by causing inflammation directly or indirectly through an altered immune system.New technologies have allowed researchers to be able to quantify the various components of the microbiome,which will allow for future developments in the etiology of IBD.Various components of the mucosal immune system are implicated in the pathogenesis of IBD and include intestinal epithelial cells,innate lymphoid cells,cells of the innate(macrophages/monocytes,neutrophils,and dendritic cells)and adaptive(T-cells and B-cells)immune system,and their secreted mediators(cytokines and chemokines).Either a mucosal susceptibility or defect in sampling of gut luminal antigen,possibly through the process of autophagy,leads to activation of innate immune response that may be mediated by enhanced toll-like receptor activity.The antigen presenting cells then mediate the differentiation of na?ve T-cells into effector T helper(Th)cells,including Th1,Th2,and Th17,which alter gut homeostasis and lead to IBD.In this review,the effects of these components in the immunopathogenesis of IBD will be discussed. | Kori L Wallace Li-Bo Zheng Yoshitake Kanazawa David Q Shih | 2014 | World Journal of Gastroenterology2014，20，1： | 45 |
| 3 | Prediction of Mammalian MicroRNA Targets显示文摘 | Benjamin P. Lewis I-hung Shih Matthew W. Jones-Rhoades David P. Bartel Christopher B. Burge | 2003 | Cell2003，，7： | 7 |
| 4 | Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease显示文摘The thiopurine drugs,6-mercaptopurine(6-MP) and azathioprine,are efficacious in the arsenal of inflammatory bowel disease(IBD) therapy.Previous reports indicate that 6-thioguanine nucleotide(6-TGN) levels correlate with therapeutic efficacy,whereas high 6-methylmercaptopurine(6-MMP) levels are associated with hepatotoxicity and myelotoxicity.Due to their complex metabolism,there is wide individual variation in patient response therein,both in achieving therapeutic drug levels as well as in developing adverse reactions.Several strategies to optimize 6-TGN while minimizing 6-MMP levels have been adopted to administer the thiopurine class of drugs to patients who otherwise would not tolerate these drugs due to side-effects.In this report,we will review different approaches to administer the thiopurine medications,including the administration of 6-mercaptopurine in those unsuccessfully treated with azathioprine;coadministration of thiopurine with allopurinol;co-administration of thiopurine with anti-tumor necrosis factor α;6-TGN administration;desensitization trials;and split dosing of 6-MP. | Kara Bradford David Q Shih | 2011 | World Journal of Gastroenterology2011，17，37： | 6 |
| 5 | A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease显示文摘Small bowel tumors and Crohn's disease are common causes of small bowel obstruction.Early stage neoplasms can easily be mistaken for Crohn's disease.Therefore,thorough work-ups including imaging studies and endoscopic evaluation with biopsies are critical for accurate diagnosis.Here we report a case of an otherwise healthy female with progressive onset of multiple,recurrent obstructive symptoms secondary to terminal ileal narrowing who was referred for management of steroid-dependent Crohn's disease.After thorough evaluation,the diagnosis was revised to myeloid granulocytic sarcoma involving the terminal ileum.In this case,a delay in diagnosis can be detrimental for prognosis,as myeloid granulocytic sarcoma is highly predictive of underlying acute myeloid leukemia and needs urgent referral for chemotherapy and/or resection. | Lola Y Kwan Stephan R Targan David Q Shih | 2011 | World Journal of Gastroenterology2011，17，19： | 3 |
| 6 | Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis显示文摘AIM To evaluate the effects of phosphatase and tension homologue deleted on chromosome ten(PTEN) gene on collagen metabolism in hepatic fibrosis and the underlying mechanisms.METHODS rat primary hepatic stellate cells(HSCs) and human LX-2 cells were transfected with adenovirus containing c DNA constructs encoding wild-type PTEN(Ad-PTEN), PTEN mutant G129 E gene(Ad-G129E), and r NA interference constructs targeting the PTEN sequence PTEN short hairpin r NA to up-regulate and downregulate the expression of PTEN. HSCs were assayed using fluorescent microscopy, real-time polymerase chain reaction, and western blotting. Moreover, a CCl_4-induced rat hepatic fibrosis model was established to investigate the in vivo effects. Hematoxylin and eosin, and Masson's trichrome were used to assess the histological changes. The expression of collagen Ⅰ and Ⅲ was assessed using immunohistochemistry and western blot analysis.RESULTS Elevated expression of PTEN gene reduced serum levels of alanine transaminase and aspartate transaminase, decreased collagen deposition in the liver, and reduced hepatocyte necrosis. In contrast, knockdown of PTEN expression had an opposite effect, such as increased collagen deposition in the liver, and was molecularly characterized by the increased expression of matrix metalloproteinase(MMP)-13(P < 0.01) and MMP-2(P < 0.01), as well as decreased expression of the tissue inhibitor of metalloproteinase(TIMP)-1(P < 0.01) and TIMP-2(P < 0.01).CONCLUSION These data indicated that gene therapy using recombinant adenovirus encoding PTEN might be a novel way of treating hepatic fibrosis. | Shu-rui Xie Jun-yan An Li-bo Zheng Xiao-Xia Huo Jian Guo David Shih Xiao-Lan Zhang | 2017 | World Journal of Gastroenterology2017，23，32： | 3 |
| 7 | 急性运动对ADHD患儿和普通儿童认知表现的影响(英文)显示文摘背景:注意力缺失过动症(attention deficit hyperactivity disorder,ADHD)是一种普通的儿童疾病,影响到大约11%的美国儿童。已有研究支持一段时间的运动有益于儿童的认知表现,数量有限的研究已证明这种影响对ADHD患儿也有效。本研究旨在探讨急性运动对ADHD患儿和普通儿童认知表现的影响。方法:让ADHD患儿和普通儿童接受为期2天、顺序平衡随机的治疗,其中一天为30 min对照状态,另一天为中等强度运动。治疗后对受试者进行认知测试。结果:运动使受试者在斯特鲁测试(Stroop Test)3种情况下的表现均有显著提高,但对伦敦塔测试(Tower of London Test)和连线测试(Trail Making Test)表现影响不大。结论:一段时间的运动能改善ADHD患儿和正常儿童的处理速度和抑制控制,但对其计划和定势转换能力没有影响。 | Aaron T.Piepmeier Chia-Hao Shih Margaret Whedon Lauren M.Williams Matthew E.Davis David A.Henning Se Yun Park Susan D.Calkins Jennifer L.Etnier | 2015 | Journal of Sport and Health Science2015，4，1： | 3 |
| 8 | Insights into IBD pathogenesis显示文摘 | David Q. Shih Stephan R. Targan | 2009 | Current Gastroenterology Reports2009，，6： | 2 |
| 9 | Recent advances in IBD pathogenesis: Genetics and immunobiology显示文摘 | David Q. Shih Stephan R. Targan Dermot McGovern | 2008 | Current Gastroenterology Reports2008，，6： | 1 |
| 10 | Increased serum levels of L‐arginine in ulcerative colitis and correlation with disease severity显示文摘 | Shih‐Kuang S.Hong Brad E.Maltz Lori A.Coburn James C.Slaughter RupeshChaturvedi David A.Schwartz Keith T.Wilson | 2009 | Inflamm Bowel Dis2009，，1： | 1 |
| 11 | Biogeography of the Indo-Australian Archipelago显示文摘 | David J. Lohman Mark de Bruyn Timothy Page Kristina von Rintelen Robert Hall Peter K.L. Ng Hsi-Te Shih Gary R. Carvalho Thomas von Rintelen | 2011 | Annual Review of Ecology, Evolution, and Systematics2011，，： | 1 |
| 12 | Regulation of apolipoprotein M gene expressed by MODY3 gene hepatocyte nuclear factor-lalpha:haploin- stdiciency is associated with reduced serum apolipoprotein M levels显示文摘 | Symi Richter David Q Shih E | 2003 | Di- abetes2003，52，12： | 1 |
| 13 | Prediction of Mammalian MicroRNA Targets显示文摘 | Benjamin P. Lewis I-hung Shih Matthew W. Jones-Rhoades David P. Bartel Christopher B. Burge | 2003 | Cell2003，，7： | 1 |
| 14 | Classification methods in the detection of new malicious emails显示文摘 | SHIH Dong-her CHIANG Hsiu-sen DAVID C Y | 2005 | Information Sciences2005，172，1： | 1 |
| 15 | Netflix显示文摘 | Willy Shih Stephen Kaufman David Spinola | | 0，，04： | 1 |
| 16 | Effect of Tumor Subtype on Survival and the Graded Prognostic Assessment for Patients With Breast Cancer and Brain Metastases显示文摘 | Paul W. Sperduto Norbert Kased David Roberge Zhiyuan Xu Ryan Shanley Xianghua Luo Penny K. Sneed Samuel T. Chao Robert J. Weil John Suh Amit Bhatt Ashley W. Jensen Paul D. Brown Helen A. Shih John Kirkpatrick Laurie E. Gaspar John B. Fiveash Veronica Chia | 2012 | International Journal of Radiation Oncology Biology Physics2012，，5： | 1 |
| 17 | Effect of the MTHFR C677T and A1298C Polymorphisms on Survival in Patients With Advanced CKD and ESRD: A Prospective Study显示文摘 | Rex L. Jamison Mei-Chiung Shih Donald E. Humphries Peter D. Guarino James S. Kaufman David S. Goldfarb Stuart R. Warren J. Michael Gaziano Philip Lavori | 2009 | American Journal of Kidney Diseases2009，，5： | 1 |
| 18 | American Cancer Society lung cancer screening guidelines显示文摘 | Richard Wender Elizabeth T. H. Fontham Ermilo Barrera Graham A. Colditz Timothy R. Church David S. Ettinger Ruth Etzioni Christopher R. Flowers G. Scott Gazelle Douglas K. Kelsey Samuel J. LaMonte James S. Michaelson Kevin C. Oeffinger Ya‐Chen Tina Shih D | 2013 | CA: A Cancer Journal for Clinicians2013，，2： | 1 |
| 19 | History of diabetes mellitus and subsequent prostate cancer risk in the NIH-AARP Diet and Health Study显示文摘 | Brook A. Calton Shih Chen Chang Margaret E. Wright Victor Kipnis Karla Lawson Frances E. Thompson Amy F. Subar Traci Mouw David S. Campbell Paul Hurwitz Albert Hollenbeck Arthur Schatzkin Michael F. Leitzmann | 2007 | Cancer Causes & Control2007，，5： | 1 |
| 20 | Prediction of Mammalian MicroRNA Targets显示文摘 | Benjamin P. Lewis I-hung Shih Matthew W. Jones-Rhoades David P. Bartel Christopher B. Burge | 2003 | Cell2003，，7： | 1 |
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