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| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | Bioretention column studies of phosphorus removal from urban storm water runoff显示文摘 | Hsieh C H Davis A P Needleman B A | 2007 | Water Environ Res2007，79，2： | 1 |
| 3 | Refinement of weedrisk assessments for biofuels using Camelina sativa as a modelspecies显示文摘 | Davis P B Menalled F D Peterson R K D | 2011 | Journal of Applied Ecology2011，48，： | 1 |
| 4 | Calcium anidotrihydroborate:a hydrogen storage material显示文摘 | Diyabalanage H V K Shrestha R P Semelsberger TA Scott B L Bowden M E Davis B L Burrell A K | | 0，，47： | 1 |
| 5 | Application of the Australian river bioassessmentsystem ( AUSRIVAS) in the Brantas River, East Java,Indonesia 显示文摘 | Hart B T Davies P E Humphrey C L | | Journal of Environmental Management0，，： | 1 |
| 6 | Comparison of parametricrepresentations of monosyllabic word recognition in continuously spoken sentences显示文摘 | MERMELSTEIN P | 1980 | IEEE Trans on Speech and Audio Processing1980，28，4： | 1 |
| 7 | Antifreeze proteins 显示文摘 | DAVIES P L SYKES B D | 1997 | Curr Opin Struct Biol1997，7，6： | 1 |
| 8 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 9 | Ex-pression patterns of cell wall-modifying enzymes during grape ber-ry development显示文摘 | NUNAN K J DAVIES C ROBINSON S P FINCHER G B | 2001 | Planta2001，214，2： | 1 |
| 10 | Mode of International Entry:An Isomorphism Perspective显示文摘 | Davis P S Desai A B Francis J D | 2000 | Journal of International Business Studies2000，31，2： | 1 |
| 11 | Comparison of parame-tric representations of monosyllabic word recognition in continuously spoken sentences显示文摘 | Davis S B Mermelstein P | 1980 | IEEE Transactions on Speech Acoustic Processing1980，28，： | 1 |
| 12 | Prediction of building integrated photovohaic cell temperatures显示文摘 | Davis M W Fanney A H Dougherty B P | 2001 | Journal of Solar Energy Egineering Trans ASME2001，123，： | 1 |
| 13 | The effects of the amplitude distribution of equal energy exposures on noise-induced hearingloss:the kurtosi smetric显示文摘 | Hamemik R P Qiu W Davis B | 2003 | J Acouse Soc Am2003，114，1： | 1 |
| 14 | Morphological instability in epitaxially strained dislocation-free solid films显示文摘 | Spencer B J Voorhees P W Davis S H | 1991 | Physical Review Letters1991，67，26： | 1 |
| 15 | Genetic dissection of the relative roles of auxin and gibberellin in the regulation of stem elongation in intact light-grown peas 显示文摘 | Yang T Davies P J Reid J B | 1996 | Plant Physiology1996，110，3： | 1 |
| 16 | Matrix cells from Wharton's jelly form neu- rons and glia显示文摘 | Mitchell KE ML Weiss BM Mitchell P Martin D Davis L Mo- rales B Helwig M Beerenstrauch K Abou - Easa T Hildreth D rroyer and S Medicetty | 2003 | Stem Cells2003，21，： | 1 |
| 17 | Yeast wall protein 1 of Candida albicans 显示文摘 | Granger B L Flenniken M L Davis D A Mitchell A P Cutler JE | 2005 | Microbiology2005，151，： | 1 |
| 18 | Extraction platform evaluations: A comparison of Automate ExpressTM, EZ1 Advanced XL, and Maxwell 16 Bench-top DNA xtraction systems显示文摘 | Davis G P King J L Budowle B | 2012 | Legal Medicine2012，14，1： | 1 |
| 19 | Resonant dynamics of an autoparametric system:a study using higher-order averaging显示文摘 | BAPPADITYA B BAJAJ A K DAVIES P | 1996 | International Journal of Nonlinear Mechanics1996，31，1： | 1 |
| 20 | The Descriptive Epidemiology of Brain Tumors显示文摘 | Davis FG McCarthy B Jukich P | 1999 | Neuroimaging Clinics of North America1999，9，4： | 1 |
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