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| 1 | Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions显示文摘Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden.Exosomes,especially those derived from mesenchymal stem cells(MSCs),are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural regeneration.In this study,we reported the differentiation of human adipose derived MSCs(hADMSCs)towards the Schwann cell(SC)phenotype(hADMSC-SCs)and then isolated exosomes from hADMSCs with and without differentiation(i.e.,dExo vs uExo).We assessed and compared the effects of uExo and dExo on antioxidative,angiogenic,anti-inflammatory,and axon growth promoting properties by using various peripheral nerve-related cells.Our results demonstrated that hADMSC-SCs secreted more neurotrophic factors and other growth factors,compared to hADMSCs without differentiation.The dExo isolated from hADMSC-SCs protected rat SCs from oxidative stress and enhanced HUVEC migration and angiogenesis.Compared to uExo,dExo also had improved performances in downregulating pro-inflammatory gene expressions and cytokine secretions and promoting axonal growth of sensory neurons differentiated from human induced pluripotent stem cells.Furthermore,microRNA(miRNA)sequencing analysis revealed that exosomes and their parent cells shared some similarities in their miRNA profiles and exosomes displayed a distinct miRNA signature.Many more miRNAs were identified in dExo than in uExo.Several upregulated miRNAs,like miRNA-132-3p and miRNA-199b-5p,were highly related to neuroprotection,anti-inflammation,and angiogenesis.The dExo can effectively modulate various peripheral nerve-related cellular functions and is promising for cell-free biological therapeutics to enhance neural regeneration. | Bo Liu Yunfan Kong Wen Shi Mitchell Kuss Ke Liao Guoku Hu Peng Xiao Jagadesan Sankarasubramanian Chittibabu Guda Xinglong Wang Yuguo Lei Bin Duan | 2022 | Bioactive Materials2022，7，8： | 3 |
| 2 | Matrix cells from Wharton's jelly form neu- rons and glia显示文摘 | Mitchell KE ML Weiss BM Mitchell P Martin D Davis L Mo- rales B Helwig M Beerenstrauch K Abou - Easa T Hildreth D rroyer and S Medicetty | 2003 | Stem Cells2003，21，： | 1 |
| 3 | Matrix ce:ls from Wharton's Jelly from neurons and glia显示文摘 | Mitchell KE Weiss ML Mitchell BM | 2003 | Stem Cells2003，21，1： | 1 |
| 4 | The prevalence of refractive errors among adults in the United States, Western Europe, and Australia 显示文摘 | Kempen JH Mitchell P Lee KE Tielsch JM Broman AT Taylor HR | 2004 | Arch Ophthalmol2004，122，4： | 1 |
| 5 | Tandem measurement of D-dimer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department显示文摘 | Mitchell M Nordenholz KE Kline JA | 2008 | Acad Emerg Med2008，15，9： | 1 |
| 6 | Tandem measurement of D-di- mer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department 显示文摘 | Mitchell M Nordenholz KE Kline JA | 2008 | ACADEMIC E- MERGENCY MEDICINE2008，15，9： | 1 |
| 7 | Direct comparision of the diagnostic accuracy of fifty protein biological markers of pulmonary embolism for use in the emergency department显示文摘 | Nordenholz KE Mitchell AM Kline JA | | 0，，10： | 1 |
| 8 | Prevalence of Age-Related Macular Degeneration in a Rural Chinese Population: The Handan Eye Study显示文摘 | Ke Yang Yuan Bo Liang Li Qin Gao Yi Peng Ran Shen Xin Rong Duan David S. Friedman Lan Ping Sun Paul Mitchell Ning Li Wang Tien Yin Wong Jie Jin Wang | 2011 | Ophthalmology2011，，7： | 1 |
| 9 | Transphntation of porcine umbilical cord matrix cells into the rat brain显示文摘 | Weiss ML Mitchell KE Hix JE | 2003 | Exp Neurol2003，182，： | 1 |
| 10 | Matrix cells from Wharton's jelly form neurons and gila 显示文摘 | Mitchell KE Weiss ML Mitchell BM | 2003 | Stem Cells2003，21，2： | 1 |
| 11 | Matrix cells from Wharton's jelly form neurons and glia 显示文摘 | Mitchell KE Weiss ML Mitchell BM | 2003 | Stem Cells2003，21，1： | 1 |
| 12 | Tandem measurement of D- dimer and myeloperoxidate or C- reactive protein to effectively screen for pulmonary embolism in the emergency department显示文摘 | MITCHELL M NORDENHELZ KE | 2008 | AEM2008，15，9： | 1 |
| 13 | Matrix cells from Wharton's jelly form neurons and glia显示文摘 | Mitchell KE Weiss ML Mitchell BM | | 0，，01： | 1 |
| 14 | Laser treatment of benign pigmented epidermal lesions using 300 nsecond pulsed and 510nm wavelength显示文摘 | Richard EF Mitchel PG Javier KE | 1993 | J Dermatol Surg Onco11993，18，： | 1 |
| 15 | The standardisation of skin care in British Columbia: a collaborative approach 显示文摘 | Nysted KE Hill JE Mitchell AM | 2005 | Oncology Nursing Forum2005，32，5： | 1 |
| 16 | Prevalence of Age-Related Macular Degeneration in a Rural Chinese Population: The Handan Eye Study显示文摘 | Ke Yang Yuan Bo Liang Li Qin Gao Yi Peng Ran Shen Xin Rong Duan David S. Friedman Lan Ping Sun Paul Mitchell Ning Li Wang Tien Yin Wong Jie Jin Wang | 2011 | Ophthalmology2011，，7： | 1 |
| 17 | A self-management programme for COPD: a randomised con- trolled trial显示文摘 | Mitchell KE Johnson-Warrington V Apps LD | 2014 | Eur Respir J2014，44，6： | 1 |
| 18 | Direct comparison of the diagnostic accuracy of fifty protein biological markers of pulmonary embolism for use in the emergency department 显示文摘 | Nordenholz KE Mitchell AM Kline JA | 2008 | Acad Emerg Med2008，15，9： | 1 |
| 19 | Tandem measurement of D- dimer and myeloperoxidase or C - reactive protein to effectively screen for pulmonary embolism in the emergency department 显示文摘 | Mitchell AM Nordenholz KE Kline JA | 2008 | Acad Emerg Med2008，15，9： | 1 |
| 20 | Tandem measurement of D-dimer and myeloperoxidase or C-reactive protein to effectively screen for pulmonary embolism in the emergency department显示文摘 | Mitchell M Nordenholz KE Kline JA | 2008 | Academic Emergency Medicine2008，15，9： | 1 |
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