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| 1 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 2 | Image-guided therapies in the treatment of hepatocellular carcinoma: A multidisciplinary perspective显示文摘A multidisciplinary approach to the treatment of patients with unresectable hepatocellular carcinoma(HCC) has led to improvements in screening, detection,and treatments. Interventional techniques includethermal ablation, transarterial chemoembolization, and radioembolization whilst stereotactic body radiation therapy also uses imaging to target the radiation. Both survival rates and cure rates have improved markedly since the introduction of these techniques. This review article describes the image guided techniques used for the treatment of HCC. | Jonathon Willatt Kevin K Hannawa Julie A Ruma Timothy L Frankel Dawn Owen Pranab M Barman | 2015 | World Journal of Hepatology2015，7，2： | 2 |
| 3 | Hepatitis C eradication with sofosbuvir leads to significant metabolic changes显示文摘AIM To assess the effect of sofosbuvir(SOF) based regimens on glycemic and lipid control.METHODS This is a retrospective analysis of hepatitis C virus(HCV)-infected patients treated and cured with a SOF regimen [SOF/ribavirin/interferon, SOF/simeprevir, or SOF/ledipasvir(LDV) ± ribavirin] from January 2014 to March 2015. Patients with hemoglobin A1C(HbA1C) and lipid panels within six months before and six months after therapy were identified and included in our study. Due to the known hemolytic effect of ribavirin, HbA1C was obtained a minimum of three months post-treatment for the patients treated with a ribavirin regimen. Medical history, demographics, HCV genotype, pre-therapy RNA, and liver biopsies were included in our analysis. The patients who started a new medication or had an adjustment of baseline medical management for hyper-lipidemia or diabetes mellitus(DM) were excluded from our analysis.RESULTS Two hundred and thirty-four patients were reviewed, of which 60 patients met inclusion criteria. Sixty-three point three percent were male, 26.7% were Caucasian, 41.7% were African American and 91.7% were infected with hepatitis C genotype 1. Mean age was 60.6 ± 6.7 years. Thirty-nine patients had HbA1C checked before and after treatment, of which 22 had the diagnosis of DM type 2. HbA1C significantly decreased with treatment of HCV(pretreatment 6.66% ± 0.95% vs posttreatment 6.14% ± 0.65%, P < 0.005). Those treated with SOF/LDV had a lower HbA1C response than those treated with other regimens(0.26% ± 0.53% vs 0.71% ± 0.83%, P = 0.070). Fifty-two patients had pre- and post-treatment lipid panels; there was a significant increase in low-density lipoprotein(LDL) and total cholesterol(TC) after treatment(LDL: 99.5 ± 28.9 mg/dL vs 128.3 ± 34.9 mg/dL, P < 0.001; TC: 171.6 ± 32.5 mg/dL vs 199.7 ± 40.0 mg/dL, P < 0.001). Pretreatment body-mass index(BMI) did not differ from post-treatment BMI(P = 0.684). CONCLUSION Eradication of HCV with a SOF regimen resulted in a significant drop in HbA1C and an increase in LDL and TC post therapy. | Amilcar L Morales Zachary Junga Manish B Singla Maria Sjogren Dawn Torres | 2016 | World Journal of Hepatology2016，8，35： | 2 |
| 4 | Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123显示文摘 | Stephen L Hempel Garry R Buettner Yunxia Q O’Malley Duane A Wessels Dawn M Flaherty | 1999 | Free Radical Biology and Medicine1999，，1： | 1 |
| 5 | Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction显示文摘 | Dawn B Takano H Tang X L | 2002 | Am J Physiol Heart Circ Physiol2002，283，2： | 1 |
| 6 | Schiflett Potential contributions of rough sets data analysis to training evaluations显示文摘 | DAWN L RIDDLE MICHAEL D COOVERT LINDA R ELLIOTT etal | 2003 | Military Psychology2003，15，： | 1 |
| 7 | Subcellular-resolu- tion molecular imaging within living tissue by fiber mi- croendoscopy 显示文摘 | Timothy J Mark C Dawn L | 2007 | Optical Society Am2007，15，16： | 1 |
| 8 | The role of social support in the stressor-strain relationship: an examination of work-family conflict显示文摘 | Dawn S Carlson Pamela L Perrewé | 1999 | Journal of Management1999，，4： | 1 |
| 9 | The Effect of Guarantees on Consumers' Evaluation of Services显示文摘 | Amy L Dawn I | 1998 | Journal of Services Marketing1998，，5： | 1 |
| 10 | Strength and stiffness of circular concrete-filled tubes 显示文摘 | CHARLES W R DAWN E L ERIC B | 2010 | Journal of Structural Engineering2010，136，： | 1 |
| 11 | IL10 Polymorphisms Are Associated with Airflow Obstruction in Severe ?^sub 1^-Antitrypsin Deficiency显示文摘 | DeMeo Dawn L Campbell Edward J Barker Alan F Brantly Mark L Eden Edward McElvaney N Gerard Rennard Stephen I Sandhaus Robert A Stocks James M Stoller James K Strange Charlie Turino Gerard Silverman Edwin K | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，1： | 1 |
| 12 | Stromal cell-derived factor-1α plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury显示文摘 | Dawn A Yan H Dingang L et al | 2004 | Circulation2004，110，21： | 1 |
| 13 | Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37显示文摘 | Mookheriee N Brown Kelly L Bowdish Dawn M E | 2006 | Immu- hal2006，176，4： | 1 |
| 14 | Facilitating Corruption and Human Rights Violations:The Role Of International Financial Institutions显示文摘 | Rothe Dawn L | | 0，，05： | 1 |
| 15 | Use of replicating oncolytic adenoviruses in combination therapy for cancer 显示文摘 | Roland L Chu L Dawn E | 2004 | Clinical Cancer Res2004，10，16： | 1 |
| 16 | The relationship life cycle: ( Ⅰ ) a network - dyad - network dynamic conceptual- ization, and(Ⅱ) the application of some classic psychological theories to its management显示文摘 | DAWN L PHILIP Z | 1997 | Research in Marketing1997，13，1： | 1 |
| 17 | Brasaemle Fixation Methods for the Study of Lipid Droplets by Im munofluorescence Microscopy显示文摘 | Deanna DiDonato Dawn L | 2003 | Journal of Histochemistry &Cytochemistry2003，51，6： | 1 |
| 18 | The Role of G protein activation in the toxicity of amyloidogenic Aβ-(1-40), Aβ-(25-35), and bovine calcitonin 显示文摘 | Dawn L Theresa AG | 2001 | Biol Chem J2001，276，： | 1 |
| 19 | An examination of factors motivating hotel outsourcing显示文摘 | Dawne L | 2011 | International Journal of Hospitality Management2011，30，4： | 1 |
| 20 | The nitric oxide hypothesis of late preconditioning 显示文摘 | Bolli R Dawn B Tang X L | 1998 | Basic Res Cardiol1998，93，5： | 1 |
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