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| 1 | 万古霉素最低抑菌浓度对甲氧西林敏感金黄色葡萄球菌心内膜炎预后的影响显示文摘金黄色葡萄球菌(金葡菌)引起的心内膜炎病死率高。万古霉素最低抑菌浓度(MIC )能影响耐甲氧西林金葡菌所致血流感染的结果,最近的数据显示,其对甲氧西林敏感金葡菌也有类似作用。本文目的是评价万古霉素M IC对氯唑西林治疗的左心金葡菌感染性心内膜炎疗效的影响。 | Cervera C Casaeda X de la Maria CG 范亚新 张菁 | 2015 | 中国感染与化疗杂志2015，15，3： | 4 |
| 2 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 3 | 醛固酮在肾血管性高血压交感神经兴奋中的作用显示文摘血管紧张素Ⅱ(angiotensin,AngⅡ)是肾血管性高血压发生的必要因素,醛固酮也在其中起作用,但其在肾血管性高血压自主神经功能障碍和肾功能障碍中的作用尚不清楚。该研究应用两肾一夹模型评估醛固酮在心血管和肾功能障碍中的作用。方法:在用螺内酯[200mg/(kg·d),7d]治疗或未治疗的两肾一夹大鼠中评估平均动脉压(mean arterial pressure,MAP)和压力感受性反射对心率的控制作用。 | Lincevicius GS Shimoura CG Nishi EE Perry JC Casarini DE Gomes GN Bergamaschi CT Campos RR 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，2： | 2 |
| 4 | Laminin-binding integrins in rat lens morpho- genesis and their regulation during fibre differentiation显示文摘 | WedereU ED Brown H O' Connor M Chamberlain CG McAvoy JW de Iongh RU | 2005 | Exp Eye Res2005，81，3： | 1 |
| 5 | Prognostic signifi- cance of radial margins of clearance in rectal cancer 显示文摘 | de Haas-Kock DF Baeten CG Jager JJ | 1996 | Br J Surg1996，83，6： | 1 |
| 6 | Tail index and quantile estimation with very high frequency data 显示文摘 | Danielsson J Vries de CG | 1997 | Journal of Empirical Finance1997，4，23： | 1 |
| 7 | Nitric oxide mediates the increase in local cerebral blood flow during focal seizures 显示文摘 | Pereira de Vaseoncelo6 A Baldwin RA Wasterlaln CG | 1995 | Proc Nail Acad Sci USA1995，92，8： | 1 |
| 8 | Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo pyridine in MRP2- deficient rats 显示文摘 | Dietrich CG de Waart DR Ottenhoff R | 2001 | Mol Pharmacol2001，59，5： | 1 |
| 9 | The body-mass index,airflow obstruction,dyspnea,and exercise capacity index in chronic obstructive pulmonary disease显示文摘 | Celli BR Cote CG Marin JM Casanova C Montes de Oca M Mendez RA Pinto Plata V Cabral HJ | 2004 | N Engl J Med2004，350，10： | 1 |
| 10 | Wallflex colonic stent placement for management of malignant colonic obstruction:a prospective study at two centers显示文摘 | Repici A De CG Luigiano C | 2008 | Gastrointest Endosc2008，67，： | 1 |
| 11 | Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘 | Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G | 2013 | Lancet Oncol2013，14，9： | 1 |
| 12 | ' Skin-CNS-bladder' reflex pathway for micturition after spinal cord injury and its un- derlying mechanisms 显示文摘 | Xiao CG de Groat WC Godec CJ | 1999 | J Urol1999，162，： | 1 |
| 13 | Phase II study of docetaxel in patients with epithelial ovarian carcinoma refractory to platinum显示文摘 | Kavansh JJ Kudelka AP de Leon CG | 1996 | Clin Cancer Res1996，2，5： | 1 |
| 14 | Advances in the pathophysiol- ogy of status epilepticus显示文摘 | Chen JW Naylor DE Wasterlain CG | 2007 | Acta Neurol Scand Supp12007，186，： | 1 |
| 15 | Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fi- brosis 显示文摘 | Andersson-SjiSland A de Alba CG Nihlberg K | 2008 | Int J Biochem Cell Biol2008，40，10： | 1 |
| 16 | Posterolateral fu-sion for radicular pain in isthmic spondylolisthesis 显示文摘 | de Loubresse CG Bon T Deburge A et a/ | 1996 | ClinOrthop Relat Res1996，，323： | 1 |
| 17 | Involvement and fragmentation:A study of parental care of hospitalized children in Brazil显示文摘 | De Lima RA Rocha SM Scochi CG | 2001 | Pediatr Nurs2001，27，56： | 1 |
| 18 | 显示文摘 | Andersson-Sjfiland A de Alba CG Nihlberg K | 2008 | Int J Bioehem Cell Biol2008，40，10： | 1 |
| 19 | Development of a small-molecule serum-and glucocorticoid-regulated kinase-1 an- tagonist and its evaluation as a prostate cancer therapeutic 显示文摘 | Sherk AB Frigo DE Schnackenberg CG | 2008 | Cancer Res2008，68，18： | 1 |
| 20 | Continuous measurement of blood volume during hemodialysis by an optical method显示文摘 | de Vries Jean-Paul Olthof CG Victor Visser | 1992 | ASAIO Journal1992，38，3： | 1 |
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