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| 1 | Treatment of prediabetes显示文摘Progression of normal glucose tolerance(NGT) to overt diabetes is mediated by a transition state called impaired glucose tolerance(IGT). Beta cell dysfunction and insulin resistance are the main defects in type 2 diabetes mellitus(type 2 DM) and even normoglycemic IGT patients manifest these defects. Beta cell dysfunction and insulin resistance also contribute to the progression of IGT to type 2 DM. Improving insulin sensitivity and/or preserving functions of beta-cells can be a rational way to normalize the GT and to control transition of IGT to type 2 DM. Loosing weight, for example, improves whole body insulin sensitivity and preserves beta-cell function and its inhibitory effect on progression of IGT to type 2 DM had been proven. But interventions aiming weight loss usually not applicable in real life. Pharmacotherapy is another option to gain better insulin sensitivity and to maintain beta-cell function. In this review, two potential treatment options(lifestyle modification and pharmacologic agents) that limits the IGT-type 2 DM conversion in prediabetic subjects are discussed. | Mustafa Kanat Ralph A De Fronzo Muhammad A Abdul-Ghani | 2015 | World Journal of Diabetes2015，6，12： | 4 |
| 2 | Insulin resistance,lipotoxicity,type 2diabetes and atherosclerosis:the missing links显示文摘 | De Fronzo RA | 2010 | Diabetologia2010，53，7： | 1 |
| 3 | Nephropathy in diabetes 显示文摘 | Mditch ME De Fronzo RA Franz MI | 2004 | Diabetes Care2004，27，： | 1 |
| 4 | From the triumvirate to the ominous octet:a new paradigm for the treatment of type 2 diabetes mellitus 显示文摘 | De Fronzo RA | 2009 | Diabe- tes2009，58，4： | 1 |
| 5 | Diabetic nephropathy显示文摘 | Molitch ME De Fronzo RA Franz MJ | 2003 | Diabetes Care2003，26，1： | 1 |
| 6 | Insulin resistance hyperinsulinmia and coronary artery disease: a complex metabasis web显示文摘 | De Fronzo AR | 1992 | Cardiovasc Pharmacol1992，11，： | 1 |
| 7 | The triumvirate: beta - cell, musele, liver, a collusion responsible for NIDDM显示文摘 | De Fronzo RA | 1988 | Diabetes1988，37，6： | 1 |
| 8 | From the Triumvirate to the Ominous Octet:A New Paradigm for the Treatment of Type 2 Diabetes Metlitus显示文摘 | Ralph A De Fronzo | 2009 | Diabetes2009，58，： | 1 |
| 9 | Effects of exenatide(exendin-4)on glycemie control and weight over 30 weeks in metformin-treated patients with type 2 diabetes显示文摘 | De Fronzo RA Ratner RE Han J | 2005 | Diabet Care2005，28，： | 1 |
| 10 | Nephropathy in diabetes显示文摘 | Molitch M E De Fronzo R A Franz M J | 2004 | DiabetesCare2004，27，11： | 1 |
| 11 | Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucose显示文摘 | De Fronzo RA Abdul-Ghani M | 2011 | Am J Cardiol2011，108，3： | 1 |
| 12 | A multifaced syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovasular disease 显示文摘 | De Fronzo RA Hames G R Taylor | 1991 | Diabetes Care1991，14，： | 1 |
| 13 | Assessment and treatment of car- diovascular risk in prediabetes :impaired glucose tolerance and im- paired fasting glucose显示文摘 | De Fronzo RA Abdul-Ghani M | 2011 | Am J Cardiol2011，108，3： | 1 |
| 14 | Insulin resistance:a multifaceted syndrome responsible for NIDDM,obesity,hypertension,dyslipidemia,and atherosclerotic cardiovascular disease显示文摘 | De Fronzo RA Ferrannini E | 1991 | Diabetes Care1991，14，3： | 1 |
| 15 | A Multifaceted syndrome responsible for NIDDM,obesity,hypertension,dyslipidemia,and atheroscl-erosis cardiovascular disease显示文摘 | De Fronzo RA Ferranini E Insulin resisrance | 1991 | Diabetes Care1991，14，3： | 1 |
| 16 | Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases 显示文摘 | Cersosimo E de Fronzo R A | 2006 | Diabetes Metab Res Rev2006，22，6： | 1 |
| 17 | Insulin resistance,hyperinsulinemia and coronary artery disease:a complex metabolic web 显示文摘 | | 1992 | J Cardiovasc Pharmacol1992，20，11： | 1 |
| 18 | A multifaced syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease显示文摘 | Ferrannini E | 1991 | Diabetes Care1991，14，： | 1 |
| 19 | Glucose clamp technique:a method for quantifying insulin secretion and resistance显示文摘 | De Fronzo R A Tobin J D Andres R | 1979 | Am J Physiol1979，237，3： | 1 |
| 20 | Nephropathy in diabetes显示文摘 | Molitch ME De Fronzo RA Franz MJ | 2004 | Diabetes Care2004，27，1： | 1 |
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