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| 1 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 2 | Quantitative Study on Nonmetallic Inclusion Particles in Steels by Automatic Image Analysis With Extreme Values Method显示文摘The presence of nonmetallic inclusion particles which appear during steelmaking process is harmful to the properties of steels,which is mainly as a function of some aspects such as size,volume fraction,shape,and distribution of these particles.The automatic image analysis technique is one of the most important tools for the quantitative determination of these parameters.The classical Student approach and the Extreme Values Method(EVM) were used for the inclusion size and shape determination and the evaluation of distance between the inclusion particles.The results thus obtained indicated that there were significant differences in the characteristics of the inclusion particles in the analyzed products.Both methods achieved results with some differences,indicating that EVM could be used as a faster and more reliable statistical methodology. | Cássio Barbosa José Brant de Campos Jneo Lopes do Nascimento Iêda Maria Vieira Caminha | 2009 | Journal of Iron and Steel Research(International)2009，16，4： | 7 |
| 3 | Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism显示文摘肿瘤坏死因素(TNF ) 联系了导致 apoptosis ligand (TRAIL/APO2L ) 是在血缘的死亡受体的约会之上导致 apoptosis 的 TNF 基因总科的一个成员。当小道对正常房间相对无毒时,它有选择地在许多转变房间导致 apoptosis。不过,胸肿瘤房间对小道的效果特别地抵抗。这里,我们报导在有 cyclin 依赖的 kinase 禁止者 roscovitine 的联合,落后于的暴露在检验的小道抵抗的乳癌房间线的多数导致了显著 apoptosis。Roscovitine 便于小道导致死亡的发信号的复杂形成和 caspase-8 的激活。FLICE 禁止的蛋白质是的 cFLIP (L) 和 cFLIP 显著地下面调整的列在后面暴露到 roscovitine 并且,确实由 siRNA 的 cFLIP isoforms 击倒敏化的胸肿瘤房间到导致小道的 apoptosis。另外,我们证明 roscovitine 强烈在胸肿瘤房间压制了 Mcl-1 表示和起来调整的 E2F1 蛋白质层次。显著地,由 siRNA 的 Mcl-1 的 silencing 敏化胸肿瘤房间到导致小道的 apoptosis。而且,由减少的 siRNA 的 E2F1 蛋白质击倒在导致小道的 apoptosis 的 roscovitine 的敏化的效果。在摘要,我们的结果为 roscovitine 的 pro-apoptotic 影响揭示 pleitropic 机制,加亮它象在在有小道的联合的乳癌的一个反肿瘤代理人的潜力。 | Gustavo Ortiz-Ferrón Rosario Yerbes Adriana Eramo Ana I López-Pérez Ruggero De Maria Abelardo Lápez-Rivas | 2008 | Cell Research2008，18，6： | 5 |
| 4 | Newinsights on glyphosate mode of action in nodularmetabolism:role of shikimate accumulation 显示文摘 | De Maria N Becerril J M Garcia-Plazaola J I | 2006 | Journalof Agricultural and Food Chemistry2006，54，7： | 1 |
| 5 | Polydatin, a natural precursor of resveratrol, in- duces cell cycle arrest and differentiation of hu- man colorectal CaCO3 cell 显示文摘 | De Maria S Scognamiglio I Lombardi A | 2013 | J Transl Med2013，11，1： | 1 |
| 6 | New insights on glyphosate mode of action in nodular metabolism: Role of shikimate accumula- tion 显示文摘 | De Maria N Becerril J M Garcla-Plazaola J I | 2006 | Journal of Agricultural and Food Chem- istry2006，54，： | 1 |
| 7 | Antioxidant Acton of Bixin Against CisplatinInduced Chromosome Aberrations and Lipid Peroxidation in Rats显示文摘 | Cec(I)lia Rodrigues Siva Lus(a)nua M Greggu Abtyes abd Maria De Lourdes P | 2001 | Pharmacological Research2001，43，6： | 1 |
| 8 | Reduction of fire hazards on large equipment显示文摘 | Maria I De Rosa | 2008 | Coal age2008，113，9： | 1 |
| 9 | Molecular mechanisms of patupilone resistance显示文摘 | Mozzetti S Iantomasi R De Maria I | 2008 | Cancer Res2008，68，10： | 1 |
| 10 | A study of the retrograda- tion process in five argentine rice starches显示文摘 | LAURA B I de MISHIMA B L MARIA C A | 2010 | LWT-Food Science and Technology2010，43，4： | 1 |
| 11 | Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis显示文摘 | Cascino I Papoff G De Maria R | 1996 | J Immunol1996，156，1： | 1 |
| 12 | Prevention ofinfections in cardiovascular implantahle electronic devices beyond the antibiotic agent显示文摘 | De Maria E Diemberger I Vassallo PL | 2014 | J Cardiovasc Med2014，15，7： | 1 |
| 13 | HuR regu- lates beta- tubuhn isotype expression in ovarian cancer显示文摘 | RASPAGLIO G DE MARIA I FILIPPETTI F | 2010 | Cancer Res2010，70，14： | 1 |
| 14 | Hepatocellular carcinoma: a role of estrogen receptorin liver显示文摘 | Villa E Grottola A Colantoni A De Maria N Buttafoco P Ferretti I Manenti F | 2002 | Ann N Y Acad Sci2002，963，： | 1 |
| 15 | Yellow Zn x Ni 1? x WO 4 pigments obtained using a polymeric precursor method显示文摘 | André Luiz M. de Oliveira Jailson M. Ferreira Márcia R.S. Silva Glauco S. Braga Luiz E.B. Soledade M.A. Maurera Maria Aldeiza Carlos A. Paskocimas Severino J.G. Lima Elson Longo Antonio Gouveia de Souza Iêda M. Garcia dos Santos | 2007 | Dyes and Pigments2007，，1： | 1 |
| 16 | Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC显示文摘 | Augusto Caraceni Geoffrey Hanks Stein Kaasa Michael I Ben- nett Cirmia Brunelli Nathan Chemy Ola Dale Franco De Conno Marie Fallon Magdi Hanna Dagny Faksvfig Haugen Gitte Juhl Samuel King PadKlepstad Eivor A Laugsand Marco Maltoni Se- bastiano Mercadante Maria Nabal Alessandra Pigni Lukas Rad- bmch Colette Reid Per Sjogren Patrick C Stone Davide Tassi- nail Giovambattista Zeppetella | 2012 | Lancet Oncol2012，13，2： | 1 |
| 17 | HuR regulates beta- tubulin isotype expression in ovarian cancer 显示文摘 | Raspaglio G De Maria I Filippetti F | 2010 | Cancer Res2010，70，14： | 1 |
| 18 | Fractal dimension and geostatistical parameters for soil micro- relief as a function of cumulative precipitation显示文摘 | Vclzquez E V Vieira S R De Maria I C | 2010 | Sci entia Agricola2010，67，1： | 1 |
| 19 | Markers of acute coronary syndrome in emergency room显示文摘 | Loria V Dato I De Maria GL | 2008 | Minerva Med2008，99，5： | 1 |
| 20 | Highly enantioselective tandem enzyme-organocatalyst crossed aldol reactions with acetaldehyde in deep-eutectic-solvents 显示文摘 | Muller C R Meiners I Dominguez de Maria P | 2014 | RSC Adv2014，4，46： | 1 |
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