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| 1 | Differentiation profile of brain tumor stem cells:a comparative study with neural stem cells显示文摘大脑肿瘤干细胞(BTSC ) 的区别侧面的理解,在肿瘤房间人口之中的关键的,将通过有神经干细胞(NSC ) 的比较借卓见进 glioma 的起源并且最终产出新途径与这难处理的疾病作斗争。这里,我们从外科的 glioma 标本的有教养、净化的 BTSC 和 NSCsfrom 人的胎儿的大脑织物,并且进一步分析了他们的细胞的生物行为,他们的特别区别性质。是期望,区分进成熟神经显型的 NSC。然而, BTSC 展出了的 Inthe 一样的区别状况区分了差别。词法上,房间变得变平并且属于第一个星期,但是逐渐地此后聚集了并且改过漂浮的肿瘤范围。在相应时期期间,无差别的房间标记 CD133 和巢在的表示率在 BTSC 不停地减少,但是 1 个星期以后,他们重获上升趋势。有趣地,区分的房间标记 GFAP 和 beta-tubulinIIIshowed 表示变化逆到无差别的房间标记的。总起来说, BTSCswere 揭示了拥有一个能力抵抗区别,它实际上代表 glioma 的恶意的行为。 | Quan Bin Zhang Xiao Yan Ji Qiang Huang Jun Dong Yu De Zhu Qing Lan | 2006 | Cell Research2006，16，12： | 34 |
| 2 | Effects of endotoxin on expression of ras, p53 and bcl-2 oncoprotein in hepatocarcinogenesis induced by thioacetamide in rats显示文摘Efectsofendotoxinonexpressionofras,p53andbcl2oncoproteininhepatocarcinogenesisinducedbythioacetamideinratsYANGJinMing1,HAN... | YANG Jin Ming 1, HAN De Wu 1, LIANG Quan Chen 2, ZHAO Jia Li 2, HAO Su Yuan 1, MA Xue Hui 1 and ZHAO Yuan Chang 1 | 1997 | World Journal of Gastroenterology1997，3，4： | 11 |
| 3 | THE STRUCTURE OF ARMILLARIZIN,A NEW PROTOILLUDANE SESQUITERPENOID AROMATIC ESTER FROM ARMILLARIA MELLEA(VAHL.EX FR)QUEL.显示文摘A new protoilludane sesquiterpenoid aromatic ester,named armillarizin(1)has been isolated from the artificially cultured mycelium of Armillaria me-llea(Vahl.ex Fr)Quel.(Tricholomataceae).Its structure was deduced on the ba-sis of spectral analyses.The relative configuration was established from thenuclear Overhauser effects and from the values of ~1H-~1H coupling constants. | Jun Shan YANG Ya Lun SU Yu Lan WANG Xiao Zhang FENG De Quan YU Xiao Tian LIANG Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing,100050 | 1990 | Chinese Chemical Letters1990，1，2： | 8 |
| 4 | Effects of dietary supplementation with essential oils and protease on growth performance,antioxidation,inflammation and intestinal function of weaned pigs显示文摘This experiment evaluated the impacts of essential oils(EO)and protease(PRO),independently or in combination,on growth performance,antioxidation,inflammation and intestinal function of weaned pigs.One hundred and sixty weaned pigs(21 d of age,BW of 6.74±0.20 kg)were randomly divided into 4 treatments with 8 replicate pens of 5 pigs per pen.Dietary treatments included the following:1)control diet(CON),2)CON with 300 mg/kg essential oils(EO),3)CON with 500 mg/kg protease(PRO),4)CON with 300 mg/kg essential oil and 500 mg/kg protease(EO + PRO).On d 8,one pig from each penwas selected for sampling.The remaining pigs were fed for an additional week and growth performance was monitored during this period.Dietary treatments had no marked effects(P>0.05)on the growth performance of pigs.However,pigs receiving EO diet had higher(P<0.05)serumglutathione peroxidase(GSH-Px)activity,and tended to decrease(P=0.063)serum concentration of tumor necrosis factor-a(TNF-a).In addition,pigs receiving EO diet had higher(P<0.05)abundances of phylum Actinobacteria,and genera Bifidobacterium,and lower(P<0.05)phylum Bacteroidetes and genera Alloprevotella in colonic digesta.Pigs receiving PRO diet decreased(P<0.05)the serum concentration of malondialdehyde(MDA)and diamine oxidase activity,increased(P<0.05)the villus height and the ratio of villus height to crypt depth in duodenum,increased sucrase activity in jejunal mucosa,and also increased the abundance of phylum Actinobacteria in colonic digesta.Furthermore,the synergistic effects of EO and PROwas observed(P<0.05)for pigs with decreasing serum TNF-a concentration and increasing serum GSH-Px activity.Collectively,the results indicated that dietary supplementation of EO and PRO had no significant effects on growth performance of weaned pigs.EO diet appeared to improve antioxidant activity and intestinal microbiota,while PRO diet improved intestinal morphology and digestive enzyme activity,and there was a synergistic effect of EO and PRO on reducing inflammatory parameters in weaned pigs. | Xie Peng Qiang Zhou Cheng Wu Jian Zhao Quan Tan Ying He Liang Hu Zhengfeng Fang Yan Lin Shengyu Xu Bin Feng Jian Li Yong Zhuo Chris Van Ginneken Xuemei Jiang De Wu Lianqiang Che | 2022 | Animal Nutrition2022，，2： | 8 |
| 5 | Stereoselective Addition of Organotitanium and Grignard Reagents to 3,5-O-isopropylidene-L-glucurono-γ-lactone显示文摘Substituted PhMgX and PhTi(OCHMe2)4MgX react with 3,5-O-isopropylidene-L-glucurono-γ-lactone 4 to give tetrads 5a-e and its stereoisomers 6a-e Tetrads 5a-e are the important intermediates in the synthesis of howiinol Al and its derivatives. The stereoselectivities of substituted PhTi(OCHMe2)4Mg (5a-e:6a-e ratio, 68-72:32-28) were better than those of substituted PhMgX(33-64:67-36) in the reaction. The effects of different substitUted groups and positions (p-Me, m-Me, o-MeO, p-Cl) of the phenyl ring on their stereoselectivies were not significant. | Hong CHEN Shao Yi SUN and De Quan YU(Institute of Meteria Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050) | 1998 | Chinese Chemical Letters1998，9，10： | 5 |
| 6 | A New Isoprenylated flavonol from the Leaves of Broussonetia kazinoki显示文摘A new isoprenylated flavonol, named broussonol A (1) was isolated from the leaves of Broussonetia kazinoki Sieb. The structure of broussonol A was characterized by chemical and spectral methods. | Pei Cheng ZHANG, Si WANG, Ying Hong WANG, Ruo Yun CHEN, De Quan YU* Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100050 | 2001 | Chinese Chemical Letters2001，12，2： | 5 |
| 7 | Detection of Repair of the Zone of Calcified Cartilage with Osteoarthritis through Mesenchymal Stem Cells by Ultrashort Echo Time Magnetic Resonance Imaging显示文摘 | Quan Zhou Shao-Lin Li Ya-Jun Ma Vicki de Tal Wei Li Ying-Hua Zhao | 2018 | Chinese Medical Journal2018，，9： | 5 |
| 8 | Three New Compounds from Forsythia Suspensa (Thunb.) Vahl显示文摘Three new compounds, suspenolic acid (1), forsythenside A (2), and forsythenside B (3) have been isolated from the fruits of Forsythia suspensa. Their smictures were elucidated by special methods including IR, 1H- and 13C-NMR, DEPT, 1H-1H COSY, 1H-13C COSY, NOE difference, HMBC, FABMS, CIMS, and chemical reactions. | Dong Sheng MING De Quan YU Shi Shan YU (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050) | 1998 | Chinese Chemical Letters1998，9，1： | 5 |
| 9 | STRUCTURE ELUCIDATION OF LIGUSTILONE FROM LIGUSTICUM SINENSIS OLIV显示文摘STRUCTUREELUCIDATIONOFLIGUSTILONEFROMLIGUSTICUMSINENSISOLIV￥DeQuanYU;RuoYunCHEN;andFengZhiXIE.(InstituteofMateriaMedica,Chine... | De Quan YU Ruo Yun CHEN and Feng Zhi XIE.(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100050) | 1995 | Chinese Chemical Letters1995，6，5： | 4 |
| 10 | Synthesis and Fungicidal Activities of 2-Alkylthio-5-(3,4,5-tribenzyloxyphenyl)-1,3,4-oxadiazoles显示文摘Ten novel 2-alkylthio-5-(3, 4, 5-tribenzyloxyphenyl)-1, 3, 4-oxadiazole derivatives (5a-j) were synthesized from methyl 3, 4, 5-trihydroxybenzoate by etherification, hydrazidation, cyclization and thioetherification reactions. The structures of 5a-j were confirmed by 1HNMR, MS spectra and elemental analysis. The results indicated that most of the compounds 5 exhibited good fungicidal activities. The activity of 5h is higher than 90% against Fusarium oxysporum and Botrytis cinereapers in 50 mg/L. | De Qing LONG De Jiang LI Wei Quan CAI Sheng Sheng CHEN | 2006 | Chinese Chemical Letters2006，17，11： | 3 |
| 11 | Synthesis and anti-TMV activity of novel N-(3-alkyl-1H-pyrazol-4-yl)-3-alkyl-4-substituted-1H-pyrazole-5-carboxamides显示文摘In order to investigate the biological activity of novel bis-pyrazole compounds,a series of N-(3-alkyl-5-(N-methylcarbamyl)- 1H-pyrazol-4-yl)-3-alkyl-4-substituted-1H-pyrazole-5-carboxamides were designed and synthesized with ethyl 3-alkyl-1H-pyrazole -5-carboxylate 1 as starting materials.N-Methyl-3-alkyl-4-amino-1H-pyrazole-5-carboxamides 6 were obtained from 1 via 5 steps.3-Alkyl-4-substitued-1H-pyrazole-5-carboxyl chlorides 4a,4b,11a,11b,11c or 12 were also obtained from 1 via several steps.Target compounds 7a-7g were obtained after the reaction of 6 with the above 1H-pyrazole-5-carboxyl chlorides.Preliminary bioassay showed some compounds possessing good inactivation effect against TMV(tobacco mosaic virus).Compound 7a showed higher activity superior to ningnanmycin at a concentration of 5.0×10^(-4) g/mL and equal activity at 1.0×10^(-4) g/mL;7b and 7c showed equal activity to virazole both at concentrations of 5.0×10^(-4) g/mL and 1.0×10^(-4) g/mL. | Da Qiang Zhang Gao Fei Xu Zhi Jin Fan Dao Quan Wang Xin Ling Yang De Kai Yuan | 2012 | Chinese Chemical Letters2012，23，6： | 3 |
| 12 | A NEW DITERPENE LACTONE FROM TRIPTERYGIUM WILFORDII显示文摘A new diterpene lactone with an ent--kaurane skeleton, named antriptolactone(1)was isolated from the roots of Tripterygium wilfordii cellected in Anhui province. Its structurewas elucidated by spectral data and chemical transformtion. | De Quan YU Feng Zhi XIE Xiao Tian LIANG Institute of Mateia Medica, Chinese Academy of Medial Sciences, Beijeng, 100050 | 1992 | Chinese Chemical Letters1992，3，6： | 3 |
| 13 | A New Diels-Alder Type Adduct and a New Flavone from the Stem and Root Bark of Morus mongolica显示文摘A new Diels-Alder type adduct mongolicin G (1) and a new flavone 5′-(1′′, 1′′-dimethyl- allyl)-5,7,2′,4′-tetrahydroxyflavone (2) were isolated from the stem and root bark of Morus mongolica. Their structures were determined by spectroscopic analysis and chiroptical methods. | Jie KANG Ruo Yun CHEN De Quan YU | 2005 | Chinese Chemical Letters2005，16，11： | 3 |
| 14 | PREPARATION,IDENTIFICATION AND INTERFACIAL ACTIVITIES OF PETROLEUM CARBOXYLATE AS SURFACTANT FOR CHEMICAL FLOODING显示文摘Petroleum carboxylate that may be suitable for tertiary oil recovery have been producedinexpensively from the fractions of Daqing crude oil by a two step process.The feed stock was firstoxidized in the vapor phase,followed by reaction of the oxidized products with sodiumhydroxide.Dilute solutions of sodium carboxylates were produced and showultralow(10-2mN/m)interfacial tensions(IFTs)against a variety of hydrocarbons with a widerange of ACN(Alkane Carbon Number).Infrared spectroscopy was used to identify the functionalgroups in the oxidized and the saponified products. | Hong De HUANG Jianghan Petroleum Institute,Jiangling,Hubei,434102You Zhen YANG Ji Xin TANG Cheng Quan HE Rong Ming ZHANG Song Mei ZHANG Daqing Petroleum Institute,Anda,Heilongjiang,151400 | 1993 | Chinese Chemical Letters1993，4，4： | 3 |
| 15 | STUDIES ON THE STRURE OF LIGUSTIPHENOL FROM LIGUSTICUM SINENCE OLIV显示文摘STUDIES ON THE STRURE OF LIGUSTIPHENOL FROM LIGUSTICUM SINENCE OLIV.￣1)STUDIESONTHESTRUREOFLIGUSTIPHENOLFROMLIGUSTICUMSINENCE... | De Quan YU Feng Zhi XIE Ruo Yun CHEN and Yan He HUANG(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050) | 1996 | Chinese Chemical Letters1996，7，8： | 2 |
| 16 | Synthesis and antitumor activity of a group ofdiosgenyl glycosides显示文摘Using orthogonal protection–deprotection glycosylation strategy, a series of diosgenyl glycosides with same of monosacchar- ides component but different in sequence were synthesized. The antitumor activity in vitro of synthesized diosgenyl glycosides was evaluated by standard MTT assay. It was observed that diosgenyl glycosides with a rhamnopyranosyl at C20 of glucopyranosyl residue show potent antitumor activity in vitro. | Shu Jie Hou Chuan Chun Zou Liang Zhou Peng Xu De Quan Yu Ping Sheng Lei | 2007 | Chinese Chemical Letters2007，18，7： | 2 |
| 17 | CD8 + T Cells That Produce Interleukin-17 Regulate Myeloid-Derived Suppressor Cells and Are Associated With Survival Time of Patients With Gastric Cancer显示文摘 | Yuan Zhuang Liu–Sheng Peng Yong–Liang Zhao Yun Shi Xu–Hu Mao Weisan Chen Ken C. Pang Xiao–Fei Liu Tao Liu Jin–Yu Zhang Hao Zeng Kai–Yun Liu Gang Guo Wen–De Tong Yan Shi Bin Tang Na Li Shu Yu Ping Luo Wei–Jun Zhang Dong–Shui Lu Pei–Wu Yu Quan–Ming Zou | 2012 | Gastroenterology2012，，4： | 2 |
| 18 | Alkaloids from the Roots of Saccopetalum prolificum显示文摘A new, alkaloid. named prolilfine (1), was isolated along with four known alkaloids. liriodenine (2). 6-hydroxyonychine (3). isooncodine (4) and discretamine (5) from the roots of Saccopetalum prolificum. The structure of I was elucidated on the basis of spectroscopic and chemical methods. | Ming Lei WANG Jiang DU Ruo Yun CHEN De Quan YU (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050) | 2000 | Chinese Chemical Letters2000，11，2： | 2 |
| 19 | Construction and prokaryotic expression of the fusion protein Stx2B-IntiminC300 of EHEC O157: H7 and its immunoprophylactic potential显示文摘To construct and express the fusion protein Stx2B-IntiminC300 of EHEC 0157 :H7, and to further investigate its immunoprophyiactic potential, the gene of Stx2B (stx2b) from EHEC 0157:H7 chromosome was cloned into pMD18-T vector. Thereafter, the amplified gene was cloned into prokaryotic expression plasmid pET-28a (+)-eaeC300, which was constructed previously. The recombinant pasmid pET-28a(+)-stx2b-eaeC300 was transformed into E. coli BL21(DE3). After inducement, the protein Stx2B-IntiminC300 was successfully expressed and analyzed with sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), Western blotting and N-terminal amino acid residual sequencing. To evaluate its immunoprophyiactic potential, it was primarily purified by ion-exchange chromatography and injected into 30 BALB/c mice with Al(OH)3 in the subscapular region. Ten days after the last booster vaccination, 20 mice were attacked with EHEC 0157: H7 lysate and the protective efficacy was observed. In the present study, the gene of Stx2B-IntiminC300 was successfully cloned into pET-28a (+) vector. The results of SDS-PAGE and Western blotting assay showed that the fusion protein was successfully expressed in the inclusion body form, accounting for 25% of total expression products, and its molecular weight was about 43 kDa. The result of the N-terminal amino acid residual sequencing showed that it was identical to that of the molecular designed. The purity was about 75 % after primary purification. Animal tests revealed that the fusion protein Stx2B-IntiminC300 has elicited high titer of protective antibody relatively. These results demonstrate that the fusion protein Stx2B-IntiminC300 is successfully expressed in prokaryotic expression system and shows certain immunoprophyiactic potential. | YONG YI Xu Hu MAO WEN DE TONG YING MA MING ZEN YONG HONG ZHU QUAN MING ZOU XIA AI JIAN PING CHENG WEI JUN ZHANG JIANG GU PING LUO | 2006 | Journal of Microbiology and Immunology2006，4，2： | 2 |
| 20 | Double-bullet radioimmunotargeting therapy in 31 patients with primary liver cancer显示文摘Doublebuletradioimmunotargetingtherapyin31patientswithprimarylivercancerWUYingDe1,ZHOUDeNan2,GANGYouQuan2,HUXiaoHua1,LIZ... | WU Ying De 1, ZHOU De Nan 2, GANG You Quan 2, HU Xiao Hua 1, LI Zhi Ge 1, SONG Xiang Qun 1, HE Hai Ping 2, YANG Ke Zheng 1 and HUANG Bing Yan 1 1Department of Chemotherapy, Affiliated Cancer Hospital, Guangxi Medical University, | 1997 | World Journal of Gastroenterology1997，3，3： | 2 |
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