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| 1 | Advances in radiotherapy and targeted therapies for rectal cancer显示文摘The last decade witnessed a significant progress in understanding the biology and immunology of colorectal cancer alongside with the technical innovations in radiotherapy.The stepwise implementation of intensitymodulated and image-guided radiation therapy by means of megavolt computed tomography and helical tomotherapy enabled us to anatomically sculpt dose delivery,reducing treatment related toxicity.In addition,the administration of a simultaneous integrated boost offers excellent local control rates.The novel challenge is the development of treatment strategies for medically inoperable patient and organ preserving approaches.However,distant control remains unsatisfactory and indicates an urgent need for biomarkers that predict the risk of tumor spread.The expected benefit of target?ed therapies that exploit the tumor genome alone is so far hindered by high cost techniques and pharmaceuticals,hence hardly justifying rather modest improvements in patient outcomes.On the other hand,the immune landscape of colorectal cancer is now better clarified with regard to the immunosuppressive network that promotes immune escape.Both N2 neutrophils and myeloid-derived suppressor cells(MDSC)emerge as useful clinical biomarkers of poor prognosis,while the growing list of anti-MDSC agents shows promising ability to boost antitumor T-cell immunity in preclinical settings.Therefore,integration of genetic and immune biomarkers is the next logical step towards effective targeted therapies in the context of personalized cancer treatment. | Alexandra Sermeus Wim Leonard Benedikt Engels Mark De Ridder | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 2 | Knowledge sharing in context: the influence of organizational commitment, communication climate and CMC use on knowledge sharing显示文摘 | Bart van den Hooff Jan A. de Ridder | 2004 | Journal of Knowledge Management2004，，6： | 2 |
| 3 | Efficacy of neurofeedback treatment in ADHD:the effects on inattention,impulsivity and hyperactivity:a meta-analysis显示文摘 | Arns M de Ridder S Strehl U | 2009 | Clin EEG Neurosci2009，40，3： | 1 |
| 4 | Image processing with neural networks - a review 显示文摘 | EGMONT-PETERSEN M DE RIDDER D HANDELS H | 2002 | Pattern Recogn2002，35，10： | 1 |
| 5 | International small business survey:a picture of entrepreneurial climate显示文摘 | HUISMAN D DE RIDDER W J | 1984 | SKIM Industrial Market Research1984，，10： | 1 |
| 6 | Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: an fMRI and LORETA EEG study显示文摘 | De Ridder D Vanneste S Kovaes S | 2011 | Neurosci Lett2011，496，： | 1 |
| 7 | An International Urogynecological Association (IUGA)/International Continence Society (ICS)joint report on the terminology for female pelvic floor dysfunction显示文摘 | Haylen BT de Ridder D Freeman RM | 2010 | Int Urogynecol J2010，21，： | 1 |
| 8 | Preoperative Helical Tomotherapy and Megavoltage Computed Tomography for Rectal Cancer: Impact on the Irradiated Volume of Small Bowel显示文摘 | Benedikt Engels Mark De Ridder Koen Tournel Alexandra Sermeus Peter De Coninck Dirk Verellen Guy A. Storme | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，5： | 1 |
| 9 | Functional anatomy of the human cochlear nerve and its role in microvascular decompressions for tinnitus显示文摘 | De Ridder D Ryu H MФfller AR | 2004 | Neurosurgery2004，54，： | 1 |
| 10 | Determination of tetracycline an- tibiotics in cow's milk by liquid chromatography/tandem mass spectrometry显示文摘 | H De Ruyck H De Ridder | 2007 | Rapid Communications in Mass Spectrome- try2007，21，9： | 1 |
| 11 | Infliximab dependency in pediatric Crohn's disease: long-term follow-up of an unselected cohort显示文摘 | de Ridder L Rings EH Damen GM | 2008 | Inflamm Bowel Dis2008，14，3： | 1 |
| 12 | Knowledge sharing in context: the influence of organizational commitment, communication climate and CMC use on knowledge sharing 显示文摘 | VAN DEN HOOFF B DE RIDDER J | 2004 | Journal of Knowledge Management2004，8，6： | 1 |
| 13 | Reduction of the gibbs phenomenon applied on nonharmonic time base distortions显示文摘 | Ridder F De Pintelon R Schoukens J | 2005 | IEEE Transactions on Instrumentation and Measurement2005，54，3： | 1 |
| 14 | Is the root entry/ exit zone important in microvaseular compression syn- dromes显示文摘 | De Ridder D Mller A Verlooy J | 2002 | Neurosurgery2002，51，42： | 1 |
| 15 | Long-term observations of regional aerosol composition at two sites in Indonesia显示文摘 | Maenhaut W De Ridder D J A Fernandez-Jimenez M T | 2002 | Nuclear Instruments and Methods in Physics Research B2002，189，： | 1 |
| 16 | Phase Ⅱ study of preoperative helical tomotherapy for rectal Cancer显示文摘 | De Ridder M Tournel K Van Nieuwenhove Y | | 0，，03： | 1 |
| 17 | Proliferative capacity of embryonic chick notochord:a comparison between PCNA positivity versus 3H-thymidine incorporation显示文摘 | Chanem E Cornelissen M De Ridder L | 1995 | Cell Biology International1995，19，： | 1 |
| 18 | An International Urogyne- cological Association (IUGA),rlntemational Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction显示文摘 | Haylen BT de Ridder D Freeman RM | 2010 | Int Urogynecol J2010，21，： | 1 |
| 19 | Is the root entry/exit zone important in mierovaseular compression syndromes 显示文摘 | De Ridder D Moller AVerlooy J | 2002 | Neurosurger- y2002，51，2： | 1 |
| 20 | Interphase death in human peripheral blood lymphocytes after moderate and high doses of low and high LET radiation: an electron microscopic approach显示文摘 | Cornelissen M Thierens H De Ridder L | 2002 | Anticancer Res2002，22，1： | 1 |
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