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| 1 | Advances in radiotherapy and targeted therapies for rectal cancer显示文摘The last decade witnessed a significant progress in understanding the biology and immunology of colorectal cancer alongside with the technical innovations in radiotherapy.The stepwise implementation of intensitymodulated and image-guided radiation therapy by means of megavolt computed tomography and helical tomotherapy enabled us to anatomically sculpt dose delivery,reducing treatment related toxicity.In addition,the administration of a simultaneous integrated boost offers excellent local control rates.The novel challenge is the development of treatment strategies for medically inoperable patient and organ preserving approaches.However,distant control remains unsatisfactory and indicates an urgent need for biomarkers that predict the risk of tumor spread.The expected benefit of target?ed therapies that exploit the tumor genome alone is so far hindered by high cost techniques and pharmaceuticals,hence hardly justifying rather modest improvements in patient outcomes.On the other hand,the immune landscape of colorectal cancer is now better clarified with regard to the immunosuppressive network that promotes immune escape.Both N2 neutrophils and myeloid-derived suppressor cells(MDSC)emerge as useful clinical biomarkers of poor prognosis,while the growing list of anti-MDSC agents shows promising ability to boost antitumor T-cell immunity in preclinical settings.Therefore,integration of genetic and immune biomarkers is the next logical step towards effective targeted therapies in the context of personalized cancer treatment. | Alexandra Sermeus Wim Leonard Benedikt Engels Mark De Ridder | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 2 | Preoperative Helical Tomotherapy and Megavoltage Computed Tomography for Rectal Cancer: Impact on the Irradiated Volume of Small Bowel显示文摘 | Benedikt Engels Mark De Ridder Koen Tournel Alexandra Sermeus Peter De Coninck Dirk Verellen Guy A. Storme | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，5： | 1 |
| 3 | Reciprocal influence of the p53 and the hy-poxic pathways显示文摘 | Sermeus A Michiels C | 2011 | Cell Death Dis2011，2，： | 1 |
| 4 | Better Interprofessional Teamwork, Higher Level of Organized Care, and Lower Risk of Burnout in Acute Health Care Teams Using Care Pathways: A Cluster Randomized Controlled Trial显示文摘 | Svin Deneckere Martin Euwema Cathy Lodewijckx Massimiliano Panella Timothy Mutsvari Walter Sermeus Kris Vanhaecht | 2013 | Medical Care2013，，1： | 1 |
| 5 | Supraclavicular brachial plexus blocks:review and current practice显示文摘 | Vermeylen K Engelen S Sermeus L | 2012 | Acta Anaesthesiol Belg2012，63，1： | 1 |
| 6 | Supraelavicular brachial plexus blocks:review and current practice 显示文摘 | Vermeylen K Engelen S Sermeus L | 2012 | Aeta Anaesthesiol Belg2012，63，1： | 1 |
| 7 | Patient safety,satisfaction,and quality of hospital care:cross sectional surveys of nurses and patients in 12 countries in Europe and the United States显示文摘 | Aiken L H Sermeus W Van den Heede K | 2012 | BMJ2012，344，： | 1 |
| 8 | Reciprocal influence of the p53 and the hypoxie pathways 显示文摘 | Sermeus A Michiels C | 2011 | Cell Death Dis2011，2，5： | 1 |
| 9 | Supraclavicular brachial plexus blocks:review and urrent practice显示文摘 | Vermeylen K Engelen S Sermeus L | 2012 | Acta Anaesthesiol Belg2012，63，1： | 1 |
| 10 | Group-level impact of work environment dimensions on burnout experiences a- mong nurses: a multivariate multilevel probit model显示文摘 | Li B Bruyneel L Sermeus W | 2013 | Int J Nurs Stud2013，50，2： | 1 |
| 11 | Measuring the intensity of nursing care:making use of the Belgian nursing minimum data set显示文摘 | Sermeus W Delesie L Van den Heede K | | 0，，07： | 1 |
| 12 | Hypoxia integration in the serological proteome analysis unmasks tumor antigens and fosters the identification of anti-phospho-e EF2 antibodies as potential cancer biomarkers显示文摘 | Grandjean M Sermeus A Branders S | 2013 | Plos One2013，，76： | 1 |
| 13 | Patient safety, satisfaction, and quality of hospital care: Cross sectional surveys of nurses and patients in 12 countries in Europe and the United States显示文摘 | Aiken L H Sermeus W Van den Heede K | 2012 | BMJ2012，344，： | 1 |
| 14 | Effects of clinical pathways do they work显示文摘 | Herck PV Vanlmecht K Sermeus W | 2004 | Journal of Integrated Care Pathways2004，7，8： | 1 |
| 15 | Eight - step method to build the clinical content of an evidence - based care pathway : the case for COPD exacerbation 显示文摘 | Lodewijckx C Decramer M Sermeus W | 2012 | Trials2012，13，1： | 1 |
| 16 | Impact of care pathways for in - hospital management of COPD exacerba, tion :a systematic review显示文摘 | Lodewijckx C Sermeus W Panella M | 2011 | International journal of nursing studies2011，48，11： | 1 |
| 17 | Hepatocytes Determine the Hypoxic Microenvironment and Radiosensitivity of Colorectal Cancer Cells Through Production of Nitric Oxide That Targets Mitochondrial Respiration显示文摘 | Heng Jiang Valeri N. Verovski Wim Leonard Ka Lun Law Marieke Vermeersch Guy Storme Dirk Van den Berge Thierry Gevaert Alexandra Sermeus Mark De Ridder | 2012 | International Journal of Radiation Oncology Biology Physics2012，，： | 1 |
| 18 | Phase II Study of Preoperative Helical Tomotherapy With a Simultaneous Integrated Boost for Rectal Cancer显示文摘 | Benedikt Engels Koen Tournel Hendrik Everaert Anne Hoorens Alexandra Sermeus Nicolas Christian Guy Storme Dirk Verellen Mark De Ridder | 2012 | International Journal of Radiation Oncology Biology Physics2012，，1： | 1 |
| 19 | Preoperative Helical Tomotherapy and Megavoltage Computed Tomography for Rectal Cancer: Impact on the Irradiated Volume of Small Bowel显示文摘 | Benedikt Engels Mark De Ridder Koen Tournel Alexandra Sermeus Peter De Coninck Dirk Verellen Guy A. Storme | 2009 | International Journal of Radiation Oncology Biology Physics2009，，5： | 1 |
| 20 | Hypoxia-induced m- odulation of apoptosis and Bcl-2 family proteins in different cancer cell types显示文摘 | Sermeus A Genin M Maincent A | 2012 | PLoS One2012，7，47： | 1 |
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