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| 1 | Interplay between intestinal alkaline phosphatase, diet, gut microbes and immunity显示文摘Intestinal alkaline phosphatase(IAP) plays an essential role in intestinal homeostasis and health through interactions with the resident microbiota, diet and the gut. IAP's role in the intestine is to dephosphorylate toxic microbial ligands such as lipopolysaccharides, unmethylated cytosine-guanosine dinucleotides and flagellin as well as extracellular nucleotides such as uridine diphosphate. IAP's ability to detoxify these ligands is essential in protecting the host from sepsis during acute inflammation and chronic inflammatory conditions such as inflammatory bowel disease. Also important in these complications is IAP's ability to regulate the microbial ecosystem by forming a complex relationship between microbiota, diet and the intestinal mucosal surface. Evidence reveals that diet alters IAP expression and activity and this in turn can influence the gut microbiota and homeostasis. IAP's ability to maintain a healthygastrointestinal tract has accelerated research on its potential use as a therapeutic agent against a multitude of diseases.Exogenous IAP has been shown to have beneficial effects when administered during ulcerative colitis,coronary bypass surgery and sepsis.There are currently a handful of human clinical trials underway investigating the effects of exogenous IAP during sepsis,rheumatoid arthritis and heart surgery.In light of these findings IAP has been marked as a novel agent to help treat a variety of other inflammatory and infectious diseases.The purpose of this review is to highlight the essential characteristics of IAP in protection and maintenance of intestinal homeostasis while addressing the intricate interplay between IAP,diet,microbiota and the intestinal epithelium. | Mehrbod Estaki Daniella DeCoffe Deanna L Gibson | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | The immediate effects of endovenousdiode 808-nm laser in the greaters aphenousvein:morphologic study and clinical implications显示文摘 | Corcos L Dini S DeAnna D | 2005 | J Vasc Surg2005，41，6： | 1 |
| 3 | Post exercise protein intake enhanceswhole-body and leg protein accretion in humans 显示文摘 | DEANNA K L | 2002 | Med Sci Sports Exerc2002，34，5： | 1 |
| 4 | Presurgical promestriene therapy in postmenopausal women with stress urinary incontinence 显示文摘 | Tinelli A Malvasi A DeAnna L | 2007 | Gynecol Endocrinol2007，23，8： | 1 |
| 5 | The immediate effects of en- dovenous diode 808 -nm laser in the greater saphenous vein: mor- phologic study and clinical implications 显示文摘 | Corcos L Dini S Deanna D | 2005 | J Vasc Surg2005，41，： | 1 |
| 6 | Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression 显示文摘 | Christina L Deanna M Melissa M | 2009 | Jorunal of Affective Disorders2009，112，： | 1 |
| 7 | The immediate effects ofen - dovenous diode 808 - nm laser in the greater saphenousvein: morphologic study and clinical implications 显示文摘 | Corcos L Dini S Deanna D | 2005 | J VaseSurg2005，41，6： | 1 |
| 8 | The immediate effects of endovenous diode 808nm laser in the greater saphenous vein:morphologyic study and clinical implications显示文摘 | Corcos L Dini S Deanna D | 2005 | J Vasc Surg2005，41，6： | 1 |
| 9 | Infiltration in homogenous sands and a mechanistic model of unstable flow显示文摘 | Steven L Geiger Deanna S Durnford | 2000 | Soil Sci Am J2000，64，： | 1 |
| 10 | Teaching Olympism in schools: Olympic Education as a focus on values education显示文摘 | Binder Deanna L | 2010 | university lectures on the Olympics2010，，： | 1 |
| 11 | Expression of the tobacco 15 - 1,3 - glucanase gene, PR - 2d, following induction of SAR with Peronospora tabacina 显示文摘 | Deanna L F Christopher B L Jeffrey F P | 2004 | Physiological and Molecular Plant Pathology2004，65，6： | 1 |
| 12 | Brasaemle Fixation Methods for the Study of Lipid Droplets by Im munofluorescence Microscopy显示文摘 | Deanna DiDonato Dawn L | 2003 | Journal of Histochemistry &Cytochemistry2003，51，6： | 1 |
| 13 | Drinks Like a Fish:Using Zebrafish to Understand Alcoholic Liver Disease 显示文摘 | Deanna L Howarth D L Passeri M | 2011 | Alcoholism Clinical and Experimental Research2011，35，5： | 1 |
| 14 | Evaluation of imiquimodfor topical treatment of vaccinia virus cutaneous infections in im-munosuppressed hairless mice 显示文摘 | Bart Tarbet E Deanna L Bentley JA | 2011 | Antiviral Research2011，90，3： | 1 |
| 15 | Hydroxyl peroxide:An effective treatment for ballast water显示文摘 | Alam M Kuzirian Eleanor C S Terry Deanna L Bechtel | 2001 | Biol Bull2001，201，： | 1 |
| 16 | Making memories stick;cell adhesion molecules in synaptic plasticity显示文摘 | DEANNA L B LYNN M S LAWERNCE S | 2000 | Trends CellBiol2000，10，： | 1 |
| 17 | The immediate effects of en-dovenous diode 808-nm laser in the greater saphenous vein: morphologie study and clinical implieations显示文摘 | Corcos L Dini S Deanna D | 2005 | J Vase Surg2005，41，10： | 1 |
| 18 | Database resources of the national center for biotechnology information显示文摘 | David L Wheeler Deanna M | 2001 | Nucleic Acids Res2001，29，： | 1 |
| 19 | Nonpoint sources显示文摘 | Line Daniel E Mc Laughlin Richard A Osmond Deanna L | 1998 | Water Environment Research1998，70，4： | 1 |
| 20 | Nonpoint sources显示文摘 | Daniel E Deanna L Richard W | 1996 | Water Environmental Research1996，68，4： | 1 |
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