|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Association ofin vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19显示文摘 | DeBaun MR Niemitz EL Feinberg AP | | 0，，01： | 1 |
| 2 | Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis显示文摘BACKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical intervention.Current diagnostic standard of care is an invasive joint aspiration.Aspirations provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(e.g.bacterial)or non-infectious(e.g.gout).Cultures can take days to result,so decisions about surgery are often made with incomplete data.Novel diagnostics are thus needed.The“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute inflammation.It has been validated in multiple cohorts across heterogeneous clinical settings.AIM To study whether the SMS holds diagnostic validity in determining the etiology of acute arthritis.METHODS We conducted a blinded,prospective,non-interventional clinical study of the SMS.All patients undergoing work-up for a septic primary joint were enrolled.Patients proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String nCounter?.SMS was calculated blinded to clinical results.RESULTS A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative cultures.The SMS had an area under the ROC curve(AUROC)of 0.87 for separating infectious from non-infectious conditions.For comparison,the AUROCs for ESR=0.58,CRP=0.6,and WBC=0.59.At 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further intervention.CONCLUSION In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic biomarkers.This quick blood test could be an important tool for early,accurate identification of acute septic joints and need for emergent surgery,improving clinical care and healthcare spending. | Blake J Schultz Timothy Sweeney Malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri Michael J Gardner | 2019 | World Journal of Orthopedics2019，10，12： | 1 |
| 3 | Nocturnal Oxygen Desaturation and Disordered Sleep as a Potential Factor in Executive Dysfunction in Sickle Cell Anemia显示文摘 | Matthew J. Hollocks Tessa B. Kok Fenella J. Kirkham Johanna Gavlak Baba P. Inusa Michael R. DeBaun Michelle de Haan | 2011 | Journal of the International Neuropsychological Society2011，，1： | 1 |
| 4 | Association of in vitro fertilization with Beckwith Wiedemann syndrome and epigenetic alterations of LIT1 and H19 显示文摘 | DeBaun MR Niemitz EL Feinberg AP | 2003 | Am J Hum Genet2003，72，1： | 1 |
| 5 | Racial differences in the survival of childhood B-precursor acute lymphoblastic leukemia:a pediatric oncology group study显示文摘 | Pollock BH DeBaun MR Camitta BM | 2000 | Clin Oncol2000，18，4： | 1 |
| 6 | 显示文摘 | Field JJ Burdick MD DeBaun MR | 2012 | PLoS One2012，7，33： | 1 |
| 7 | Chronic Blood Transfusion Therapy Practices to Treat Strokes in Children with Sickle Cell Disease显示文摘 | Terianne Lindsey Nutrena Watts‐Tate Elaine Southwood Julie Routhieaux Janice Beatty Diane Calamaras Melissa Phillips Gwendolyn Lea Evelyn Brown Michael R. DeBaun | 2005 | Journal of the American Academy of Nurse Practiti2005，，： | 1 |
| 8 | Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia 显示文摘 | DeBaun MR Gordon M McKinstry RC | 2014 | N Engl J Med2014，371，8： | 1 |
| 9 | Accuracy of neurologic examination and history in detecting evidence of MRI-diagnosed cerebral infarctions in children with sickle cell haemoglobinopathy显示文摘 | Siegel MJ DeBaun MR | 1995 | J Child1995，10，： | 1 |
| 10 | Controlled trial of transfusions for silent cerebralinfarcts in sickle cell anemia显示文摘 | DeBaun MR Gordon M McKinstry RC | 2014 | N Engl J Med2014，371，： | 1 |
| 11 | Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiiedemann syndrome and is independent of insulin-like growth factor II imprinting显示文摘 | Lee MP DeBaun MR Mitsuya K | 1999 | Proc Natl Acad Sci USA1999，96，9： | 1 |
| 12 | Low frequency of p57KIP2 mutation in BECK with-Wiedemann syndrome显示文摘 | Lee MP Debaun M Randhawa G | 1997 | Am J Hum Genet1997，61，： | 1 |
| 13 | Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and HI9 显示文摘 | DeBaun MR Niemitz EL Feinberg AP | 2003 | Am J Hum Genet2003，72，1： | 1 |
| 14 | Association of in vitro fertilization with Beckwith-Wiedemannsyndrome and epigenetic alterations of LIT1 and H19显示文摘 | Debaun MR Niemitz EL Feinberg AP | 2003 | Am J Hum Genet2003，72，1： | 1 |
| 15 | Silent cerebral infarcts:a review on a prevalent and progressive cause of neurologic injury in sickle cell anemia显示文摘 | DeBaun MR Armstrong FD McKinstry RC | 2012 | Blood2012，119，： | 1 |
| 16 | Prospects for primary stroke prevention in children with sickle cell anaemia显示文摘 | Jordan LC Casella JF DeBaun MR | 2012 | Br J Haematol2012，157，： | 1 |
| 17 | Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19显示文摘 | DeBaun MR Niemitz EL Feinberg AP | 2003 | Am J Hum Genet2003，72，1： | 1 |
| 18 | Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LITl and H19显示文摘 | Niemitz EL Feinberg AP | 2003 | Am J Hum Genet2003，72，1： | 1 |
| 19 | Degradation of fenitrothion in forest soil and effects on forest soil microbes 显示文摘 | Spillner C J Debaun J R Menn J J | 1979 | J Agr Food Chem1979，27，： | 1 |
| 20 | Simpson Golabi Behmel Syndrome: Progress toward Understanding the Molecular Basis for Overgrowth, Malformation, and Cancer Predisposition显示文摘 | Michael R. DeBaun Jennifer Ess Scott Saunders | 2001 | Molecular Genetics and Metabolism2001，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员