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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | Product Mix and Earnings Volatility at Commercial Banks: Evidence from a Degree of Total Leverage Model显示文摘 | Robert DeYoung Karin P. Roland | 2001 | Journal of Financial Intermediation2001，，1： | 3 |
| 3 | Nontraditional banking activities and bank failures during the financial crisis显示文摘 | Robert DeYoung G?khan Torna | 2013 | Journal of Financial Intermediation2013，，3： | 2 |
| 4 | Borrower–lender distance, credit scoring, and loan performance: Evidence from informational-opaque small business borrowers显示文摘 | Robert DeYoung Dennis Glennon Peter Nigro | 2007 | Journal of Financial Intermediation2007，，1： | 2 |
| 5 | Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice显示文摘Background:Amyotrophic lateral sclerosis(ALS)is a disease characterized by a progressive degeneration of motor neurons leading to paralysis.Our previous MRI diffusion tensor imaging studies detected early white matter changes in the spinal cords of mice carrying the G93A-SOD1 mutation.Here,we extend those studies using ultra-high field MRI(17.6 T)and fluorescent microscopy to investigate the appearance of early structural and connectivity changes in the spinal cords of ALS mice.Methods:The spinal cords from presymptomatic and symptomatic mice(80 to 120 days of age)were scanned(ex-vivo)using diffusion-weighted MRI.The fractional anisotropy(FA),axial(AD)and radial(RD)diffusivities were calculated for axial slices from the thoracic,cervical and lumbar regions of the spinal cords.The diffusion parameters were compared with fluorescence microscopy and membrane cellular markers from the same tissue regions.Results:At early stages of the disease(day 80)in the lumbar region,we found,a 19% decrease in FA,a 9% decrease in AD and a 35% increase in RD.Similar changes were observed in cervical and thoracic spinal cord regions.Differences between control and ALS mice groups at the symptomatic stages(day 120)were larger.Quantitative fluorescence microscopy at 80 days,demonstrated a 22% reduction in axonal area and a 22% increase in axonal density.Tractography and quantitative connectome analyses measured by edge weights showed a 52%decrease in the lumbar regions of the spinal cords of this ALS mice group.A significant increase in ADC(23.3%)in the ALS mice group was related to an increase in aquaporin markers.Conclusions:These findings suggest that the combination of ultra-high field diffusion MRI with fluorescent ALS mice reporters is a useful approach to detect and characterize presymptomatic white matter micro-ultrastructural changes and axonal connectivity anomalies in ALS. | Rodolfo G.Gatto Manish Y.Amin Daniel Deyoung Matthew Hey Thomas H.Mareci Richard L.Magin | 2018 | Translational Neurodegeneration2018，7，1： | 2 |
| 6 | Plasminogen activator inhibitor type 1 increases neointima formation in balloon-injured rat carotid arteries 显示文摘 | Deyoung MB Tom C Dichek DA | 2001 | Circulation2001，104，16： | 1 |
| 7 | p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis显示文摘 | LEONG CO KUPERWASSER N DEYOUNG MP | 2006 | Cancer cell2006，9，： | 1 |
| 8 | The stomatin/ prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3 L1 adipocytes显示文摘 | LIU J DEYOUNG S M ZHANG M | 2005 | Biol Chem2005，280，16： | 1 |
| 9 | The p63/p73 network mediates chemosensitivity tocisplatin in a biologically defined subset of primarybreast cancers 显示文摘 | LEONG C 0 VIDNONIC N DEYOUNG M P | 2007 | J Clin Invest2007，117，5： | 1 |
| 10 | The Effects of Geographic Expansion on Bank Efficiency 显示文摘 | Berger A N DeYoung R | 2001 | Journal of Financial Services Research2001，19，23： | 1 |
| 11 | The Orphan Steroid Receptor Nur77 Family Member Nor-1 Is Essential for Early Mouse Embryogenesis显示文摘 | DeYoung RA Baker JC Cado D | 2003 | J Biol Chem2003，278，47： | 1 |
| 12 | Product Mix and Earnings Volatility at Commercial Banks:Evidence from a Degree of Total Leverage Model显示文摘 | DeYoung Robert and Karin E Roland | 2001 | Journal of Financial Intermediation2001，10，： | 1 |
| 13 | Telomerase reverse transcriptase subunit expression is associated with chondrossrcoma malignancy显示文摘 | J·A·Martin B·R·DeYoung S·Gitelis | 2004 | Clinical Orthopaedics and Related Research2004，，426： | 1 |
| 14 | The design of a pedicle flap in the rat to study necrosis and its Prevention显示文摘 | McFarlane R M Deyoung G Henry R A | 1965 | Plast Reconstr Surg1965，35，： | 1 |
| 15 | Effect of bar - code - assisted medication administration on medica- tion error rates in an adult medical in- tensive care unit显示文摘 | DeYoung JL Van DerKooi ME Bar- letta JF | 2009 | Am J Health - Syst Pharm2009，66，12： | 1 |
| 16 | How the Internet Affects Output and Performance at Community Banks 显示文摘 | DeYoung R Lang W W Nolle D L | 2007 | Journal of Banking & Finance2007，31，： | 1 |
| 17 | The Performance of De Novo Commercial Banks: A Profit Efficiency Approach 显示文摘 | Robert DeYoung Iftekhar Hasan | 1998 | Journal of Banking and Finance1998，，22： | 1 |
| 18 | The effects of geographic ex- pansion on bank efficiency 显示文摘 | Berger A N DeYoung R | 2001 | Journal of Financial Services Research2001，19，： | 1 |
| 19 | Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDDl-mediated 14-3-3 shuttling显示文摘 | DeYoung MP Horak P SoferA | 2008 | Genes Dev2008，22，2： | 1 |
| 20 | The regulation of miRNA-211 expression and its role in melanoma eel1 invasiveness 显示文摘 | Mazar J DeYoung K Khaitan D | 2010 | PLoS One2010，5，13： | 1 |
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