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| 1 | Offline two-dimensional liquid chromatography coupled with ion mobility-quadrupole time-of-flight mass spectrometry enabling fourdimensional separation and characterization of the multicomponents from white ginseng and red ginseng显示文摘Inherent complexity of plant metabolites necessitates the use of multi-dimensional information to accomplish comprehensive profiling and confirmative identification.A dimension-enhanced strategy,by offline two-dimensional liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry(2 D-LC/IM-QTOF-MS)enabling four-dimensional separations(2 D-LC,IM,and MS),is proposed.In combination with in-house database-driven automated peak annotation,this strategy was utilized to characterize ginsenosides simultaneously from white ginseng(WG)and red ginseng(RG).An offline 2 DLC system configuring an Xbridge Amide column and an HSS T3 column showed orthogonality 0.76 in the resolution of ginsenosides.Ginsenoside analysis was performed by data-independent high-definition MSE(HDMSE)in the negative ESI mode on a Vion?IMS-QTOF hybrid high-resolution mass spectrometer,which could better resolve ginsenosides than MSEand directly give the CCS information.An in-house ginsenoside database recording 504 known ginsenosides and 58 reference compounds,was established to assist the identification of ginsenosides.Streamlined workflows,by applying UNIFI?to automatedly annotate the HDMSEdata,were proposed.We could separate and characterize 323 ginsenosides(including 286 from WG and 306 from RG),and 125 thereof may have not been isolated from the Panax genus.The established 2 D-LC/IM-QTOF-HDMSEapproach could also act as a magnifier to probe differentiated components between WG and RG.Compared with conventional approaches,this dimensionenhanced strategy could better resolve coeluting herbal components and more efficiently,more reliably identify the multicomponents,which,we believe,offers more possibilities for the systematic exposure and confirmative identification of plant metabolites. | Tiantian Zuo Chunxia Zhang Weiwei Li Hongda Wang Ying Hu Wenzhi Yang Li Jia Xiaoyan Wang Xiumei Gao Dean Guo | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 9 |
| 2 | Study on Fat and Thin Analysis of Tongue Body Based on Two- Dimensional Ultrasonic Imaging显示文摘In the development of traditional Chinese medicine in China for fi ve thousand years, the tongue clinic occupies a very important position. In Chinese medicine, it is an irreplaceable role in the diagnosis and treatment of Chinese medicine of important method. Tongue diagnosis as one of the most characteristic of Chinese medicine diagnosis has been from the previous subjective observation, relying on the experience to judge the era into the new era of tongue diagnosis objectifi cation, quantifi cation, and the introduction of computer digital image processing technology to more Accurate diagnosis. This article will mainly introduce the current in the Chinese and Western medicine on all aspects of the tongue diagnosis of the objective, micro, quantitative progress, the characteristics of tongue images and a variety of processing techniques, including tongue image automatic segmentation, and tongue fat and thin The Relationship and Modernization of Organ Pathology in Viscera. At the same time, a tongue-sized measurement method is introduced. Two-dimensional ultrasound imaging is used as a means of inspection to establish a set of ultrasonic tongue-sized measurement methods. The measured parameters include the two longitudinal planes of the tongue and the crosssection of the tongue. Out of the tongue size of the data, the overall analysis of the size of the tongue shape. This method combines some of the confi guration line spacing, area, and circumference measurement functions to directly measure the data. Finally, through the accuracy test of the measurement method, it is proved that the measurement result of tongue two-dimensional ultrasound imaging is accurate. All the eff orts of modernization are committed to the Chinese medicine tongue medicine to scientifi c can be quantifi ed;Chinese medicine tongue diagnosis will also make a greater contribution to modern medicine. | Yanguo Hu Yaying Zhao Dean Fu | 2018 | Medical Imaging Process & Technology2018，1，1： | 2 |
| 3 | The interfacialheat transfer coeYcient in hot die forging of titaniumalloy显示文摘 | Hu Z M Brooks J W Dean T A | 1998 | Proceedings of the Institution of MechanicalEngineers Part C: Journal of Mechanical EngineeringScience1998，212，6： | 1 |
| 4 | Semiparametric dimension reduction estimation for mean response with missing data显示文摘 | HU Zonghui DEAN A QIN Jing | 2010 | Biometrika2010，97，2： | 1 |
| 5 | Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma显示文摘 | Limin Xia Wenjie Huang Dean Tian Hongwu Zhu Yongguo Zhang Hao Hu Daiming Fan Yongzhan Nie Kaichun Wu | 2012 | Journal of Hepatology2012，，3： | 1 |
| 6 | A study of surface topography, frication and lubricants in metalforming显示文摘 | Hu Z M Dean T A | 2000 | International Journal of Machine Tools & Manufacture2000，，40： | 1 |
| 7 | Alternative die designs in netshape forging of gears显示文摘 | Cai J Dean T A Hu Z M | 2004 | Materials Processing Technology2004，150，： | 1 |
| 8 | Experimental and theoretical analysis of deformation and microstructural evolution in the hot-die forging of titanium alloy aerofoil sections 显示文摘 | Hu Z M Brook J W Dean T A | 1999 | Journal of Materials Processing Technology1999，88，13： | 1 |
| 9 | Three-dimensional finite element modelling of a titanium aluminide aerofoil forging显示文摘 | Brooks J W Dean T A Hu Z M | 1998 | J Mater Process Technol1998，8081，： | 1 |
| 10 | Aspects of forging of titanium alloys and the production of blade forms 显示文摘 | Hu Z M Dean T A | 2001 | J mater Process Technol2001，111，13： | 1 |
| 11 | Aspects of forging of titanium alloys and production of blade forms显示文摘 | HU Z M DEAN T A | 2001 | Journal of Materials Processing Technology2001，111，13： | 1 |
| 12 | Experimental and theoretical analysis of deformation and microstructural evolution in the hot-die forging of titanium alloy aerofoil sections显示文摘 | HU Z M BROOKS J W DEAN T A | 1999 | Journal of Materials Processing Technology1999，88，： | 1 |
| 13 | Experimental and theoretical analysis of deformation and microstructural evolution in the hot-die forging of titanium alloy aerofoil sections显示文摘 | Hu Z M Brooks J W Dean T A | 1999 | J Mater Proc Tech1999，88，： | 1 |
| 14 | Three-di- mensional finite element modeling of a titanium alumi- nide aerofoil forging 显示文摘 | BROOKS J W DEAN T A HU Z M | 1998 | Materials Processing Technol- ogy1998，，： | 1 |
| 15 | Experimental and theoretical analysis of deformation and microstructural evolution in the hot-die forging of titanium alloy aerofoil sections显示文摘 | HU Z M BROOKS J W DEAN T A | 1999 | J Mater Process Tchol1999，88，： | 1 |
| 16 | Aspects of forging of Titanium alloys and the production of blade forms 显示文摘 | Hu Z M Dean T A | 2001 | J mater Process Technol2001，111，13： | 1 |
| 17 | Three-dimensional finite element modeling of a titanium aluminuim aerofoil forging显示文摘 | Brooks J W Dean T A Hu Z M | 1998 | J Mater Process Technol1998，8081，： | 1 |
| 18 | Alternative die designs in net-shape forging of gears 显示文摘 | Cai J Dean T A Hu Z M | 2004 | Materials Processing Technology2004，150，： | 1 |
| 19 | A study of surface topography, friction and lubricants in metalforming显示文摘 | Z.M Hu T.A Dean | 2000 | International Journal of Machine Tools and Manufacture2000，，11： | 1 |
| 20 | A Study of Surface Topography,Friction and Lubricants in Metalforming显示文摘 | Hu Z M Dean T A | 2004 | International Journal of Machine Tools & Manufacture2004，44，： | 1 |
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