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| 1 | Microbiota transplantation: concept, methodology and strategy for its modernization显示文摘烘便的 microbiota 移植(FMT ) 在最近的年里成为了 biomedicine 和临床的药的一个研究焦点。从为不同疾病的 FMT 的临床的反应为与各种各样的混乱联系的 microbiota 主人相互作用提供了证据,包括 Clostridium 顽固感染,煽动性的肠疾病,糖尿病 mellitus,癌症,肝肝硬化, gutbrain 疾病和其它。为了讨论使用微生物从古老的中国治疗人的疾病到电流的经验,时代应该在向前移动标准化 FMT 并且完成更好的未来是重要的。这里,我们基于文学和州的专家观点从 FMT 考察 microbiota 移植的变化概念到选择 microbiota 移植, FMT 的方法论发展和 stepup FMT 策略。 | Faming Zhang Bota Cui Xingxiang He Yuqiang Nie Kaichun Wu Daiming Fan | 2018 | Protein & Cell2018，9，5： | 79 |
| 2 | Aeroservoelastic modeling and analysis of a canard-configured air-breathing hypersonic vehicles显示文摘Air-breathing hypersonic vehicles (HSVs) are typically characterized by interactions of elasticity, propulsion and rigid-body flight dynamics, which may result in intractable aeroservoelastic problem. When canard is added, this problem would be even intensified by the introduction of low-frequency canard pivot mode. This paper concerns how the aeroservoelastic stability of a canard-configured HSV is affected by the pivot stiffnesses of all-moveable horizontal tail (HT) and canard. A wing/pivot system model is developed by considering the pivot torsional flexibility, fuselage vibration, and control input. The governing equations of the aeroservoelastic system are established by combining the equations of rigid-body motion, elastic fuselage model, wing/pivot system models and actuator dynamics. An unsteady aerodynamic model is developed by steady Shock-Expansion theory with an unsteady correction using local piston theory. A baseline controller is given to provide approximate inflight characteristics of rigid-body modes. The vehicle is trimmed for equilibrium state, around which the linearized equations are derived for stability analysis. A comparative study of damping ratios, closed-loop poles and responses are conducted with varying controller gains and pivot stiffnesses. Available bandwidth for control design is discussed and feasible region for pivot stiffnesses of HT and canard is given. | Zeng Kaichun Xiang Jinwu Li Daochun | 2013 | Chinese Journal of Aeronautics2013，26，4： | 7 |
| 3 | Scalable microfabrication of three-dimensional porous interconnected graphene scaffolds with carbon spheres for high-performance all carbon-based micro-supercapacitors显示文摘As one of the most important micro energy storage devices(MESDs),graphene-based micro-supercapacitors(G-MSCs)possess the advantages of excellent flexibility,long cycle life,affordability and high reliability.In most cases,constructing three-dimensional(3D)graphene networks is widely utilized to promote the permeation of electrolyte and enhance the utilization of active materials.In this work,conventional freeze-drying process is utilized in the fabrication of G-MSCs to constitute 3D interconnected networks micro-electrodes,and further by regulating the composition of inks,carbon spheres(CSs)at different mass loadings are introduced into the graphene scaffolds to further increase the active sites of the micro-electrodes.The fabricated all carbon-based MSC with the optimal mass loading of CSs(0.406 mg cm^(-2))exhibits a high specific areal capacitance of 17.01mF cm^(-2)at the scan rate of 10mV s^(-1)and a capacitance retention of 93.14%after 10000 cycles at the scan rate of 500 mV s^(-1).The proposed microfabrication process is facile and fully compatible with modern microtechnologies and will be highly suitable for large-scale production and integration. | Yiming Chen Minghao Guo Liang He Wei Yang Lin Xu Jiashen Meng Xiaocong Tian Xinyu Ma Qiang Yu Kaichun Yang Xufeng Hong Liqiang Mai | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 4 | Transjugular intrahepatic portosystemic shunt for portal vein thrombosis with symptomatic portal hypertension in liver cirrhosis显示文摘 | Guohong Han Xingshun Qi Chuangye He Zhanxin Yin Jianhong Wang Jielai Xia Zhiping Yang Ming Bai Xiangjie Meng Jing Niu Kaichun Wu Daiming Fan | 2010 | Journal of Hepatology2010，，： | 5 |
| 5 | The Prognostic and Chemotherapeutic Value of miR-296 in Esophageal Squamous Cell Carcinoma显示文摘 | Liu Hong Yu Han Hongwei Zhang Mengbin Li Taiqian Gong Li Sun Kaichun Wu Qingchuan Zhao Daiming Fan | 2010 | Annals of Surgery2010，，6： | 3 |
| 6 | Fecal microbiota transplantation through mid‐gut for refractory C rohn’s disease: Safety, feasibility, and efficacy trial results显示文摘 | Bota Cui Qiang Feng Honggang Wang Min Wang Zhaoyuan Peng Pan Li Guangming Huang Zheng Liu Ping Wu Zhining Fan Guozhong Ji Xin Wang Kaichun Wu Daiming Fan Faming Zhang | 2015 | J Gastroenterol Hepatol2015，，1： | 3 |
| 7 | Fish Consumption and Colorectal Cancer Risk in Humans: A Systematic Review and Meta-analysis显示文摘 | Shengjun Wu Bin Feng Kai Li Xia Zhu Shuhui Liang Xufeng Liu Shuang Han Biaoluo Wang Kaichun Wu Danmin Miao Jie Liang Daiming Fan | 2012 | The American Journal of Medicine2012，，6： | 2 |
| 8 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 9 | Overexpressed CacyBP/SIP leads to the suppression of growth in renal cell carcinoma显示文摘 | Shiren Sun Xiaoxuan Ning Jie Liu Lili Liu Yu Chen Shuang Han Yanqi Zhang Jie Liang Kaichun Wu Daiming Fan | 2007 | Biochemical and Biophysical Research Communications2007，，4： | 2 |
| 10 | Development of a simple molecular marker specific for detecting the self-compatibleS4′ haplotype in sweet cherry (Prunus avium L.)显示文摘 | Mo Zhu Xiaoming Zhang Kaichun Zhang Lijie Jiang Limin Zhang | 2004 | Plant Molecular Biology Reporter2004，，4： | 2 |
| 11 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 12 | MicroRNA-19a/b regulates multidrug resistance in human gastric cancer cells by targeting PTEN显示文摘 | Fang Wang Ting Li Bin Zhang Hong Li Qiong Wu Li Yang Yongzhan Nie Kaichun Wu Yongquan Shi Daiming Fan | 2013 | Biochemical and Biophysical Research Communications2013，，3： | 2 |
| 13 | USP33, a new player in lung cancer, mediates Slit-Robo signaling显示文摘Ubiquitin 特定的朊酶(USP33 ) 33 是调整多样的细胞的过程的多功能的蛋白质。在肺癌症的 USP33 的表示和角色仍然保持未经勘探。在这研究,我们证明 USP33 在肺癌症病人的多重队是下面调整的, USP33 的那低表情与差的预后被联系。USP33 调停 Slit-Robo 在肺癌症房间移植发信号。USP33 的 Downregulation 在肺癌症房间减少 Robo1 的蛋白质稳定性,提供为在调停的 USP33 功能的以前未知的机制在肺癌症房间的裂缝活动。一起拿, USP33 是在调整 Slit-Robo 发信号的肺癌症的一个新播放器。我们的数据建议 USP33 可以作为一个预示的标记是为有潜力的肺癌症的候选人肿瘤 suppressor。 | Pushuai Wen Ruirui Kong Jianghong Liu Li Zhu Xiaoping Chen Xiaofei Li Yongzhan Nie Kaichun WU Jane Y. Wu | 2014 | Protein & Cell2014，5，9： | 2 |
| 14 | Dysregulation of cellular signaling in gastric cancer显示文摘 | William K.K. Wu Chi H. Cho Chung W. Lee Daiming Fan Kaichun Wu Jun Yu Joseph J.Y. Sung | 2010 | Cancer Letters2010，，2： | 2 |
| 15 | Arbitrage pricing theory-based Gaussian temporal factor analysis for adaptive portfolio management显示文摘 | Chiu Kaichun Xu Lei | 2004 | Decision Support Systems2004，37，4： | 1 |
| 16 | Hydrogen im- proves glycemic control in typel diabetic animal model by promoting glucose uptake into skeletal muscle 显示文摘 | Amitani H Akihiro A Kaichun C | 2013 | PloS One2013，8，53： | 1 |
| 17 | Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma显示文摘 | Limin Xia Wenjie Huang Dean Tian Hongwu Zhu Yongguo Zhang Hao Hu Daiming Fan Yongzhan Nie Kaichun Wu | 2012 | Journal of Hepatology2012，，3： | 1 |
| 18 | Construction and performance test of a novel polarization sensor for navigation显示文摘 | Jinkui Chu Kaichun Zhao Qiang Zhang Tichang Wang | 2008 | Sensors & Actuators: A Physical2008，，1： | 1 |
| 19 | The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease显示文摘 | Sumei Sha Bin Xu Xin Wang Yongguo Zhang Honghong Wang Xiangyun Kong Hongwu Zhu Kaichun Wu | 2012 | Diagnostic Microbiology & Infectious Disease2012，，： | 1 |
| 20 | Mesenchymal Stem Cells Promote Epithelial to Mesenchymal Transition and Metastasis in Gastric Cancer Though Paracrine Cues and Close Physical Contact显示文摘 | Zengfu Xue Xiumin Wu Xiong Chen Yali Liu Xin Wang Kaichun Wu Yongzhan Nie Daiming Fan | 2015 | Biochem2015，，4： | 1 |
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