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| 1 | Mechanisms underlying feed intolerance in the critically ill: Implications for treatment显示文摘Malnutrition is associated with poor outcomes in critically ill patients. Although nutritional support is yet to be proven to improve mortality in non-malnourished critically ill patients, early enteral feeding is considered best practice. However, enteral feeding is often limited by delayed gastric emptying. The best method to clinically identify delayed gastric emptying and feed intolerance is unclear. Gastric residual volume (GRV) measured at the bedside is widely used as a surrogate marker for gastric emptying, but the value of GRV measurement has recently been disputed. While the mechanisms underlying delayed gastric emptying require further investigation, recent research has given a better appreciation of the pathophysiology. A number of pharmacological strategies are available to improve the success of feeding. Recent data suggest a combination of intravenous metoclopramide and erythromycin to be the most successful treatment, but novel drug therapies should be explored. Simpler methods to access the duodenum and more distal small bowel for feed delivery are also under investigation. This review summarises current understanding of the factors responsible for, and mechanisms underlying feed intolerance in critical illness, together with the evidence for current practices. Areas requiring further research are also highlighted. | Adam Deane Marianne J Chapman Robert J Fraser Laura K Bryant Carly Burgstad Nam Q Nguyen | 2007 | World Journal of Gastroenterology2007，13，29： | 18 |
| 2 | Purification and characterization of a new xylanase ( APX-II) from the fungus Aureobasidium pullulans Y-2311-1 显示文摘 | Li X L Zhang Z Q Dean J F | 1993 | Applied and Environmental Microbiology1993，59，10： | 1 |
| 3 | Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia 显示文摘 | Deane AM Nguyen N Q Stevens J E | 2010 | J Clin Endocrinol Metab2010，95，： | 1 |
| 4 | The effects of steroids during sepsis depend on dose and severity of illness: an updated meta-a nalysis显示文摘 | Minneci P C Deans K J Eichacker P Q | 2009 | Clin Microbiol Infect2009，，4： | 1 |
| 5 | Minimally invasive technique of triple anterior screw fixation for an acute combination at-las-axis fracture:case report and literature review显示文摘 | Dean Q Jiefu S Jie W | | 0，，02： | 1 |
| 6 | Point of ze- ro charge determination in soils and minerals via tra- ditional methods and detection of electroacoustic mobility显示文摘 | Appel C Ma L Q Dean Rhue R | 2003 | Geoderma2003，113，1： | 1 |
| 7 | Numerical simulation of deformation in multi-point sandwich forming显示文摘 | Zhang Q Dean T A Wang Z R | 2006 | International Journal of Machine Tools & Manufacture2006，46，： | 1 |
| 8 | Minimally invasive technique of triple anterior screw fixation for an acute combination atlas - axis fracture: case report and literature review 显示文摘 | Dean Q Jiefu S Jie W | 2010 | Spinal Cord2010，2，： | 1 |
| 9 | Proteomics of the flesh fly brain reveals an abundance of npregulated heat shock proteins during pupal diapause显示文摘 | Li A Q Popova B A Dean D H | 2007 | J Insect Physiol2007，53，4： | 1 |
| 10 | Influence of apatite seeds on the synthesis of calcium phosphate cement 显示文摘 | Yang Q Z Troe Zynski T Dean Mo Liu D M | 2002 | Biomaterials2002，23，： | 1 |
| 11 | The mechanics of multi-point sandwich forming显示文摘 | Zhang Q Wang Z R Dean T A | 2008 | International Journal of Machine Tools and Manufacture2008，48，1213： | 1 |
| 12 | The crystal and molecular structure of beryllium hydride显示文摘 | Smith G S Johnson Q C Deane K S | 1988 | Solid State Commun1988，67，5： | 1 |
| 13 | Mechanisms of lead, copper, and zinc retention by phosphate rock 显示文摘 | Xinde C Lena Q M Dean R R | 2004 | Environmental pollution2004，131，3： | 1 |
| 14 | Proteomics of the flesh fly brain reveals an abundance of upregulated heat shock proteins during pupal diapause 显示文摘 | Li A Q Popova-Butler A Dean D H | 2007 | Journal of|nsect Physiology2007，53，4： | 1 |
| 15 | Proteomics of the flesh fly brain reveals an abundance of upregulated heat shock proteins during pupal diapause显示文摘 | Li A Q Popova-Butler A Dean D H | 2007 | Journal of Insect Physiology2007，53，4： | 1 |
| 16 | The effects of steroids during sepsis depend on dose and severity of illness:an updated me ta-analysis显示文摘 | Minneci P C Deans K J Eichacker P Q | 2009 | Clin Microbiol Infect2009，15，4： | 1 |
| 17 | Proteomics of the flesh fly brain reveals an abun- dance of upregulated heat shock proteins during pupal diapause显示文摘 | LI A Q POPOVA-BUTLER A DEAN D H | 2007 | J Insect Physiol2007，53，4： | 1 |
| 18 | Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance显示文摘 | Zhang G Bai H Zhang H Dean C Wu Q Li J | 2011 | Neuron2011，69，： | 1 |
| 19 | Nanostructure toughened epoxy resins显示文摘 | Dean J M Verghese N E Pham H Q etal | 2003 | Macromolecules2003，36，25： | 1 |
| 20 | Mechanisms of lead, copper, and zinc retention by phosphate rock显示文摘 | Xinde C Lena Q M Dean R R | 2004 | Environmental Pollution2004，131，3： | 1 |
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